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  • 1
    ISSN: 1432-0428
    Keywords: Keywords Advanced glycation end products ; blood retinal barrier ; diabetic retinopathy ; Ne-(carboxymethyl)lysine ; vascular endothelial growth factor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Both advanced glycation end products and vascular endothelial growth factor are believed to play a role in the pathogenesis of diabetic retinopathy. It is known that vascular endothelial growth factor causes retinal neovascularization and a breakdown of the blood-retinal barrier; how advanced glycation end products affect the retina, however, remains largely unclear. The substance Ne-(carboxymethyl)lysine is a major immunologic epitope, i. e. a dominant advanced glycation end products antigen. We generated an anti-Ne-(carboxymethyl)lysine antibody to investigate the relationship between the localization of advanced glycation end products and that of vascular endothelial growth factor in 27 human diabetic retinas by immunohistochemistry. Nine control retinas were also examined. In all 27 diabetic retinas, Ne-(carboxymethyl)lysine was located in the thickened vascular wall. In 19 of the 27 retinas, strand-shaped Ne-(carboxymethyl)lysine immunoreactivity was also observed around the vessels. In all 27 diabetic retinas, vascular endothelial growth factor revealed a distribution pattern similar to that of Ne-(carboxymethyl)lysine. Vascular endothelial growth factor was also located in the vascular wall and in the perivascular area. Neither Ne-(carboxymethyl)lysine nor vascular endothelial growth factor immunoreactivity was detected in the 9 control retinas. Vessels with positive immunoreactivity for Ne-(carboxymethyl)lysine and/or vascular endothelial growth factor were counted. A general association was noted between accumulation of Ne-(carboxymethyl)lysine and expression of vascular endothelial growth factor in the eyes with non-proliferative diabetic retinopathy (p 〈 0.01) and proliferative diabetic retinopathy (p 〈 0.05). [Diabetologia (1997) 40: 764–769]
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Keywords Gene therapy ; diabetic retinopathy ; photocoagulation ; retrovirus ; β-galactosidase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diabetic retinopathy is a major cause of acquired blindness due to the development of retinal neovascularization and associated traction retinal detachment. It is commonly treated with retinal photocoagulation therapy; however, progression to blindness remains a significant problem. To determine the feasibility of adjunctive anti-angiogenic gene therapy, we evaluated the capability of retroviral vectors, which transfer exogenous genes only into dividing cells, to transfer and express a β-galactosidase gene selectively into photocoagulation sites. Thirty-five rabbits received 30 retinal photocoagulation burns in the right eye followed 2 days later by β-galactosidase (G1nBgSvNa) or control (G1XSvNa) vector injection into the subretinal space. β-galactosidase expression was observed in the photocoagulation sites from 5 days after vector administration (31.7 ± 7.0 %) to 12 weeks (6.7 ± 3.4 %). Immunohistochemical studies of the treated retinas using antibody Ber-MAC3 and anti-cytokeratin antibodies revealed that transduced cells were macrophages and retinal pigment epithelial cells. To determine feasibility in a primate, two monkeys received 10 laser burns in the macula superior to the fovea followed 2 days later by G1nBgSvNa vector. β-galactosidase expression was found in photocoagulation sites and foveal retina was well preserved. We conclude that gene transfer to retinal photocoagulation sites provides stable expression of the transduced gene with relatively high efficiency. This feasibility study suggests the possibility of transferring genes encoding for anti-angiogenic factors into photocoagulation sites to improve the efficacy of laser photocoagulation therapy. [Diabetologia (1998) 41: 500–506]
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 20 (1995), S. 82-84 
    ISSN: 1432-0509
    Keywords: Lymphangioma ; Spleen ; MRI ; CT, septation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of histologically confirmed cystic lymphangioma of the spleen was presented. On MR imaging, the mass was shown as multiloculated hyperintensity areas on T2-weighted images, corresponding to dilated lymphatic spaces. The septa were demonstrated as hypointensity bands, corresponding to abundant fibrous connective tissues. MR findings correlated well with histologic findings. MRI was a useful noninvasive modality for the diagnosis.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0789
    Keywords: Key words Organic material application ; Hot water extractable C ; Soil microbial biomass ; Soil neutral sugar ; Soil available N
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  The effect of short-term bark compost (Ba) and leaf litter (Li) applications on the labile soil organic matter (SOM) status was investigated. The SOM status studied in this paper includes soil microbial biomass, soil available N, hot water extractable C (HwC) and N (HwN) and soil neutral sugar-C composition. The soil microbial biomass C (MBC) and N (MBN), soil available N, HwC and HwN increased upon application of Ba and Li. No quantitative relationship was observed between application of organic material and MBC, MBN or soil available N. A positive linear correlation was observed between MBN and HwC but not between MBN and soil available N. Among the various soil neutral sugar C, xylose C (Xyl) content in Ba plots showed a remarkable increase but mannose C (Man) did not differ among Fer (fertilizer), Ba or Li plots. Soil neutral sugar C had a positive linear correlation with soil available N, MBN and HwC. The proportion of MBN : TN is positively correlated with the Xyl/Man ratio. The increase in the proportion of MBN in SOM seems to occur with the increase of SOM derived from plant debris.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 25 (1997), S. 372-381 
    ISSN: 1432-0789
    Keywords: Key words Cropping systems ; Biodynamic farms ; Soil organic matter fractions ; Microbial biomass ; Soil quality indicators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Effects of cropping systems on soil organic matter (SOM) in a pair of conventional and biodynamic mixed cropping farms were investigated. Soil samples (0–75 and 75–150-mm depths) were analysed for total carbon (TC), total nitrogen (TN), microbial biomass C (BC) and microbial biomass N (BN), and sequentially extracted for labile and stable SOM using cold water, hot water, acid mixtures and alkalis. In the biodynamic farm, TC and TN decreased with increasing period of cropping but the reverse occurred under pastures. These were not shown in soils from the conventional farm, probably due to N fertilizer additions. Under pastures, increases in SOM were attributed to greater biological N2 fixation and the return of plant residues and excreta from grazing animals. Overall, sensitive SOM quality indicators found for labile SOM were BN, BN:TN and HC:TC, and for stable SOM were HCl/HFC, HCl/HFC:TC, humin C, humin N, humin C:TC and humin N:TN. The BN and BN:TN were better indicators than BC and BC:TC. The humin fraction was strongly related to both labile and stable SOM fractions suggesting that humin contained non-extractable strongly complexed SOM components with mineral matter and also non-extractable plant and microbial residual components.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 1 (1968), S. 30-37 
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Zusammenfassung Die Kreislaufwirkungen einer neuen blutdrucksenkenden Substanz, Dichlorphenylaminoimidazolin (DCAI) wurden an 17 normotonen und 17 hypertonen Versuchspersonen untersucht. Die folgenden Parameter wurden gemessen: Arterieller Blutdruck, peripherer Venendruck, Muskeldurchblutung, Hautdurchblutung, Herzfrequenz, Gesamt-Blutvolumen und die Ausscheidung von Brenzkatechinaminen und Vanillin-Mandelsäure. DCAI wurde in Einzeldosen von 0.1–0.3 mg intravenös bzw. bei länger dauernden Experimenten in Tagesdosen von 0.3–1.5 mg per os verabreicht. — DCAI bewirkte intravenös gegeben, einen durchschnittlich 2 min dauernden Anstieg sowohl des systolischen als auch des diastolischen arteriellen Blutdrucks, dem ein langanhaltender Druckabfall folgte. Die Herzfrequenz nahm während beider Phasen gering ab. Der periphere Venendruck änderte sich nicht signifikant. Die Muskeldurchblutung blieb unverändert oder nahm vorübergehen gering zu. Unmittelbar nach der Injektion von DCAI fiel die Hautdurchblutung bis auf 50–60% der Ruhedurchblutung ab, anschließend stieg she allmählich wieder in Richtung auf die Ausgangswerte an, ohne these jedoch während der Beobachtungszeit zu erreichen. — Im Verlauf einer wirksamen oralen Behandlung mit DCAI bei 9 Hypertonikern änderte sich das Gesamt-Blutvolumen nicht signifikant. — Die Ausscheidung von Katecholaminen und Vanillin-Mandelsäure wurde durch einmalige intravenöse Gabe von 0.15 mg DCAI nicht sicher beeinflußt. — Die durch Adrenalin, Noradrenalin und Angiotensin ausgelösten Reaktionen des Blutdxucks, des Venendrucks sowie der Muskel — und Hautdurchblutung wurden durch DCAI qualitativ nicht verändert. Die Intensität der durch allo 3 Substanzen ausgelösten Durchblutungsabnahme in der Haut war infolge des durch DCAI stark verminderten Ausgangswertes herabgesetzt. — Tolazoline antagonisierte die Wirkungen von DCAI auf den arteriellen Blutdruck und die Hautdurchblutung. Es kommt klinisch als Antidot in Betracht. — Die Resultate wurden im Zusammenhang mit den hämodynamischen Veränderungen während der ersten (pressorischen) und zweiten (depressorischen) Phase der DCAI-Wirkung diskutiert.
    Notes: Summary The circulatory effects of a new antihypertensive agent, dichlorophenylamino-imidazoline (DCAI), were investigated in 17 normotensive and 17 hypertensive subjects. The following parameters were measured: Arterial pressure (AP), peripheral venous pressure (PVP), muscle blood flow (MBF), skin blood flow (SBF), heart rate (HR), total blood volume (TBV), and the excretion of catecholamines (CA) and vanillinmandelic acid (VMA). DCAI was administered in single doses of 0.15–0.3 mg intravenously or, in long-term experiments, in daily doses of 0.3–1.5 mg per os. — DCAI i. v. produced a short (mean: 2 min) increase in both systolic and diastolic AP, followed by a long lasting decrease. HR was slightly reduced during both phases. PVP was not significantly altered. MBF was unchanged or transiently slightly increased. Immediately after injection of DCAI, SBF sharply decreased to 50–60% of the resting flow; subsequently it rose gradually towards control values without reaching them during the time of observation. —Effective oral treatment with DCAI in 5 hypertensive patients produced no change in TBV. — The urinary excretion of CA and VMA was not significantly altered by a single i. v. dose of 0.15 mg DCAI. — The responses of AP, PVP, MBF and SBF to adrenaline, noradrenaline and angiotensin were not altered qualitatively by pro-treatment with single i. v. doses of DCAI. The duration of the depressor effect of adrenaline is, however, slightly but significantly prolonged. The decrease in SBF elicited by all 3 substances is diminished following DCAI, most probably as a consequence of the reduction in the control values caused by DCAI. Tolazoline antagonized the effects of DCAI on AP and SBF. It may be useful clinically as an antidote. — The results are discussed with regard to the hemodynamic changes occurring during the first (pressor) and second (depressor) phase of action of DCAI.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Keywords: Cerebral angiography ; craniopharyngioma ; computed tomography ; third ventricle tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Out of 155 cases of craniopharyngioma seen in the past 47 years, 19 are considered unusual. These 19 cases have been placed under the following headings— 1. unusual topography, and 2. associated vascular pathology. Since CT scanning offers important information about extension of craniopharyngiomas, it is very helpful for planning operative approach. However, cerebral angiography is still important for demonstrating vascular pathology.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 106 (1964), S. 371-378 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 171 (1990), S. 845-851 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 18 (1965), S. 371-376 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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