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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 46 (1994), S. 209-213 
    ISSN: 1432-1041
    Keywords: Insomnia ; Temazepam ; elderly ; efficacy ; tolerance ; intermittent administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Temazepam, 7.5 mg was evaluated in the sleep laboratory in 8 elderly insomniacs, using a 14-night protocol (4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights). With short-term use temazepam was found to be effective, producing a significant improvement in total wake time from baseline (100 vs. 145 min). With continued drug administration, total wake time remained below baseline but not significantly so (125 vs. 145 min). During drug administration, there were no major CNS and behavioral adverse effects reported such as daytime sedation, memory impairment or hyperexcitability (daytime anxiety). Following drug withdrawal, there was no significant increase in wakefulness, i.e., no rebound insomnia (150 vs. 145 min). In summary, temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects. Use of hypnotic drugs is an adjunctive therapy which should be for a short-term period with subsequent short-term intermittent use as needed. Because of its low propensity for producing rebound insomnia, temazepam can be effectively used in this manner.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 72 (1968), S. 1475-1482 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of operations research 5 (1986), S. 463-484 
    ISSN: 1572-9338
    Keywords: Branch and bound design ; tree enumeration strategies ; discrete nonlinear programs ; nonlinear integer test problems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract This paper is concerned with computational experimentation leading to the design of effective branch and bound algorithms for an important class of nonlinear integer programming problems, namely linearly constrained problems, which are used to model several real-world situations. The main contribution here is a study of the effect of node and branching variable selection and storage reduction strategies on overall computational effort for this class of problems, as well as the generation of a set of adequate test problems. Several node and branching variable strategies are compared in the context of a pure breadth-first enumeration, as well as in a special breadth and depth enumeration combination approach presented herein. Also, the effect of using updated pseudocosts is briefly addressed. Computational experience is presented on a set of eighteen suitably-sized nonlinear test problems, as well as on some random linear integer programs. Some of the new rules proposed are demonstrated to be significantly superior to previously suggested strategies; interestingly, even for linear integer programming problems.
    Type of Medium: Electronic Resource
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