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  • 1
    Electronic Resource
    Electronic Resource
    Receptor Interactions at Noradrenergic Neur ones (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 604 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb31994.x
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  • 2
    Electronic Resource
    Electronic Resource
    Blockade of α2-adrenoceptors increases opioid , μ-receptor-mediated inhibition of the firing rate of rat locus coeruleus neurones (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 108-108 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180685
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells by Y3-type neuropeptide Y receptors via the adenylate cyclase/protein kinase A system (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 337-347 
    Details
    ISSN: 1432-1912
    Keywords: Neuropeptide Y ; Catecholamines ; Cyclic adenosine monophosphate ; Chromaflin cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of neuropeptide Y [NPY(1–36)] and related peptides on the voltage-dependent currents and the nicotinic acetylcholine receptor (nAChR) currents (IACh) of bovine adrenal chromafptn cells was investigated using the whole-cell patch clamp technique. Catecholamine release from single chromaffin cells was measured by means of fast cyclic voltammetry. The potency order of these peptides in inhibiting IACh evoked by nicotine was NPY(1–36), NPY (16–36) 〉 peptide YY(PYY) 〉 [Leu31, Pro34] NPY. NPY(16–36) produced a similar degree of inhibition, irrespective of whether nicotine or an equipotent concentration of acetylcholine was used to evoke IACh. NPY(16–36) failed to alter voltage-dependent inward or outward currents. Intracellular cAMP, and extracellular dibutyryl-cAMP, produced a slowly developing increase in IACh. Intracellular cAMP, extracellular 8-Br-cAMP or dibutyryl-cAMP, and an inhibitor of cyclic nucleotide phosphodiesterases 3-isobutyl-l-methylxanthine (IBMX), decreased the inhibitory effect of NPY(16–36) on lACh. Although the intracellular application of the cAMP-dependent protein kinase A inhibitor [PKI(14–24)amide] alone did not alter IACh, it potentiated the effect of NPY(16–36) in interaction experiments. While the NPY(16–36)-induced inhibition of IACh was reversed on washout of the peptide, the slightly shorter C-terminal fragment NPY(18–36) caused a long-lasting depression of both IAch and catecholamine secretion evoked by nicotine. This depression was smaller in the presence of extracellular 8-Br-cAMP than in its absence. NPY(18–36) did not alter the secretory activity induced by a high concentration of potassium. It appears that, by activating Y3-receptors, NPY inhibits nAChR-current and the resulting secretion of catecholamines from bovine chromaffin cells. This process may involve a G protein-mediated decrease in intracellular cAMP with a subsequent decrease in the degree of phosphorylation of the nAChR-channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169073
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  • 4
    Electronic Resource
    Electronic Resource
    Subtype determination of soma-dendritic α2-autoreceptors in slices of rat locus coeruleus (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 356 (1997), S. 159-165 
    Details
    ISSN: 1432-1912
    Keywords: Key words Locus coeruleus ; Action potential discharge ; Noradrenaline ; α2-Autoreceptor ; α2-Adrenoceptor ; ƒα2D -Adrenoceptor ; Phentolamine ; Rauwolscine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to subclassify the soma-dendritic α2-autoreceptors in the locus coeruleus (LC) of the rat by means of antagonists. To this end, the frequency of spontaneous action potentials was recorded extracellularly from single LC neurones in brain slices. The neurones fired spontaneously at an average rate of 1 Hz. The selective α2-adrenoceptor agonist 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14,304) and noradrenaline decreased the action potential discharge with IC50 values of 5 and 510 nM, respectively. The concentration-inhibition curves of UK 14,304 and noradrenaline were shifted to the right by phentolamine (0.15 μM) and rauwolscine (0.15 μM) but not by prazosin (1 μM). Apparent K d values of phentolamine were 17 nM (against UK 14,304) and 20 nM (against noradrenaline). Apparent K d values of rauwolscine were 47 nM (against UK 14,304) and 70 nM (against noradrenaline). (+)-Oxaprotiline (1 μM) suppressed the firing of the neurones within 10 to 33 min. In the continued presence of oxaprotiline, phentolamine and rauwolscine restored firing with EC50 values of 120 and 250 nM, respectively. Prazosin (1 μM) again was ineffective. All three antagonist affinity estimates – against UK 14,304, exogenous noradrenaline and endogenous noradrenaline (that accumulates in the extracellular space in the presence of oxaprotiline) – yield an affinity order phentolamine 〉 rauwolscine 〉〉 prazosin, prazosin being ineffective even at a concentration of 1 μM. These findings identify the soma-dendritic α2-autoreceptors of the LC as the rat variant of the α2A/D-adrenoceptor, i.e. α2D. Not only presynaptic but also soma-dendritic α2-autoreceptors may at least predominantly be α2A/D throughout the nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005036
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells by Y3-type neuropeptide Y receptors via the adenylate cyclase/protein kinase A system (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 337-347 
    Details
    ISSN: 1432-1912
    Keywords: Key words Neuropeptide Y ; Catecholamines ; Cyclic adenosine monophosphate ; Chromaffin cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The effect of neuropeptide Y [NPY(1–36)] and related peptides on the voltage-dependent currents and the nicotinic acetylcholine receptor (nAChR) currents (IACh) of bovine adrenal chromaffin cells was investigated using the whole-cell patch clamp technique. Catecholamine release from single chromaffin cells was measured by means of fast cyclic voltammetry. The potency order of these peptides in inhibiting IACh evoked by nicotine was NPY(1–36), NPY (16–36)〉peptide YY(PYY)〉[Leu31, Pro34]NPY. NPY(16–36) produced a similar degree of inhibition, irrespective of whether nicotine or an equipotent concentration of acetylcholine was used to evoke IACh. NPY(16–36) failed to alter voltage-dependent inward or outward currents. Intracellular cAMP, and extracellular dibutyryl-cAMP, produced a slowly developing increase in IACh. Intracellular cAMP, extracellular 8-Br-cAMP or dibutyryl-cAMP, and an inhibitor of cyclic nucleotide phosphodiesterases 3-isobutyl-1-methyl-xanthine (IBMX), decreased the inhibitory effect of NPY(16–36) on IACh. Although the intracellular application of the cAMP-dependent protein kinase A inhibitor [PKI(14–24)amide] alone did not alter IACh, it potentiated the effect of NPY(16–36) in interaction experiments. While the NPY(16–36)-induced inhibition of IACh was reversed on washout of the peptide, the slightly shorter C-terminal fragment NPY(18–36) caused a long-lasting depression of both IACh and catecholamine secretion evoked by nicotine. This depression was smaller in the presence of extracellular 8-Br-cAMP than in its absence. NPY(18–36) did not alter the secretory activity induced by a high concentration of potassium. It appears that, by activating Y3-receptors, NPY inhibits nAChR-current and the resulting secretion of catecholamines from bovine chromaffin cells. This process may involve a G protein-mediated decrease in intracellular cAMP with a subsequent decrease in the degree of phosphorylation of the nAChR-channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169073
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Equilibration in intermediate-energy heavy-ion collisions within a relativistic mean-field two-fluid model (1991)
    Springer
    The European physical journal 340 (1991), S. 385-391 
    Details
    ISSN: 1434-601X
    Keywords: 24.10.Cn ; 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A two-fluid model with meanσ- andω-fields is formulated for the treatment of heavy-ion collisions at incident energies around 1 GeV/u. In this energy range Fermi and Bose statistics for baryons and pions, respectively, cannot be replaced by Boltzmann statistics. The collisional coupling between the two fluids is formulated in terms of the effective nucleon-nucleon cross-sections in nuclear medium taking Pauli blocking into account. For two counterstreaming nuclear fluids the comparison of results obtained from our relativistic mean-field two-fluid model (RMF-TFM) and the relativistic Landau-Vlasov equation shows good agreement in the gross properties of the equilibration process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290326
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  • 7
    Electronic Resource
    Electronic Resource
    Theory of mean primary charge distribution in low energy fission of even-even nuclei (1966)
    Springer
    The European physical journal 197 (1966), S. 246-261 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A molecular model of fission is introduced in which the compound nucleus before scission is described. The ground state wave function is assumed to be a BCS wave function. The single particle wave functions are expanded in terms of eigenfunctions of the unperturbed spherical fragments. The BCS wave function is determined from the minimum condition for the total energy. The fragment masses, the centers of mass, and the total proton and neutron numbers are kept constant. The resulting BCS and Hartree-Bogoliubov equations are solved approximately within the framework of an extended Nilsson model. The numerical results for the charge distribution in low energy fission of236U are in agreement with experiments. The heavier (lighter) fragment has on the average 0.5 protons less (more) than expected on the basis of the socalled unchanged charge distribution (UCD). At magic configurations the charge distribution shows characteristic deviations from the average value due to the shell structure of the fragments. The charge distribution seems to result mainly from three competing effects: a) from the level density of the unperturbed fragments in the vicinity of the Fermi energy. b) from the Coulomb interaction between the fragments, and c) from the asymmetry energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01325942
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  • 8
    Electronic Resource
    Electronic Resource
    Stability and instability of a hot and dilute nuclear droplet (2002)
    Springer
    The European physical journal 14 (2002), S. 43-51 
    Details
    ISSN: 1434-601X
    Keywords: PACS. 21.60.Ev Collective models – 21.65.+f Nuclear matter – 25.70.Mn Projectile and target fragmentation – 25.70.Pq Multifragment emission and correlations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Results on dissipative isoscalar modes of a hot and dilute nuclear droplet are presented. As compared to the adiabatic limit (part I), realistic dissipation yields a substantial reduction of the growth rates for all unstable modes, while the area of spinodal instability in the (ϱ,T)-plane remains unchanged. The qualitative features of multifragmentation through spinodal decomposition as obtained in the adiabatic limit are not significantly affected by dissipation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/iepja1369
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  • 9
    Electronic Resource
    Electronic Resource
    Strangeness production in nuclear matter and expansion dynamics (2003)
    Springer
    The European physical journal 32 (2003), S. 399-415 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Thermodynamical properties of hot and dense nuclear matter are analyzed and compared for different equations of state (EoS). It is argued that the softest point of the equation of state and the strangeness separation on the phase boundary can manifest themselves in observables. The influence of the EoS and the order of the phase transition on the expansion dynamics of nuclear matter and strangeness excitation function is analyzed. It is shown that the bulk properties of the strangeness production in A-A collisions depend only weakly on the particular form of the EoS. The predictions of different models are related with experimental data on strangeness production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2003-01374-2
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of relaxation phenomena in heavy-ion collisions (1978)
    Springer
    The European physical journal 284 (1978), S. 209-216 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The transfer of mass, as well as the dissipation of relative kinetic energy and relative angular momentum in deeply inelastic heavy-ion collisions are studied as functions of time. Based on the determination of a parametrized deflection function from the experimental angular distributions, a classical model for the calculation of the mean interaction time as a function of initial relative angular momentum is presented. The method allows to include also those processes which correspond to long interaction times. The model is applied to determine mass transport coefficients from experimental mass (or element) distributions. The resulting mass drift and diffusion coefficients are accurate within less than 30% and compare well with the systematics obtained from the microscopic transport theory. The energy loss as function of interaction time is consistent with the following picture: Fast dissipation of the radial part of the kinetic energy accompanied by the loss of angular momentum with a larger relaxation time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411331
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