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  • 1
    Electronic Resource
    Electronic Resource
    Determination of iron-carbon monoxide geometry in the subunits of carbonmonoxy hemoglobin M Boston using femtosecond infrared spectroscopy (1993)
    s.l. : American Chemical Society
    Biochemistry 32 (1993), S. 5809-5814 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00073a013
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vesicles of polymeric bilayer and monolayer membranes (1981)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 5945-5947 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00409a071
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibitory effect of α-α-diphenyl-α-propoxyacetic acid-L-methyl-4-piperidyl ester hydrochloride on the activity of the rat urinary bladder (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 1388-1389 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary α-α- Diphenyl-α- propoxyacetic acid-l-methyl-4-piperidyl ester hydrochloride(propiverine) significantly decreased the volume-pressure ratio of the rat urinary bladder and suppressed efferent nervous activity of the bladder branch of the pelvic nerve during vesical extension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990118
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  • 4
    Electronic Resource
    Electronic Resource
    Low-molecular-weight enzyme inhibitors suppress the development of experimental allergic encephalomyelitis (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1405-1407 
    Details
    ISSN: 1420-9071
    Keywords: Enzyme inhibitors ; experimental allergic encephalomyelitis ; cell surface enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We tested the activity of low-molecular-weight enzyme inhibitors with immunomodifying actions on the suppression of experimental allergic encephalomyelitis (EAE). Of the agents tested the inhibitors of alkaline phosphatase, aminopeptidase B and esterase gave significant protection againts the clinical expression of EAE in guinea pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951914
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  • 5
    Electronic Resource
    Electronic Resource
    Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 737-743 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Apoptosis; Bcl-2; protein kinase C; follicular lymphoma; phosphorylation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. A newly established human lymphoma cell line (OZ) has the t(14;18)(q32;q21) translocation and expresses large amounts of Bcl-2 compared to CCRF-CEM cells. VP-16 (40 μg/mL), a promising agent against lymphoma, caused DNA fragmentation (26.9% of total DNA) typical for apoptosis at 6 h in CCRF-CEM cells, but no significant changes in OZ cells until 24 h after the addition of VP-16. However, coincubation with calphostin C (0.2 μg/mL), a protein kinase C (PKC) inhibitor, induced DNA fragmentation in VP-16-treated OZ cells (13.5% of total DNA) at 6 h after the treatment. Simultaneous immunoblot analysis revealed that this induction of apoptosis coincided with the downregulation of serine-phosphorylated Bcl-2 (13% of control cells). By contrast, apoptosis induced by VP-16 in CCRF-CEM cells was attenuated by the addition of 0.5 μM phorbol 12-myristate 13-acetate, a potent PKC stimulator. These observations suggest that Bcl-2 function is partly regulated by phosphorylation/dephosphorylation mechanisms of the PKC system, and that phosphorylated Bcl-2 in lymphoma cells may play a role in the prevention of apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050093
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  • 6
    Electronic Resource
    Electronic Resource
    Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 251-254 
    Details
    ISSN: 1432-0533
    Keywords: Malignant gliomas ; Allelic delection ; Restriction fragment length polymorphisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gene delection of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytome cases. One glioblastoma case showed loss of heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue. The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294641
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  • 7
    Electronic Resource
    Electronic Resource
    Preoperative angiographical prediction of the necessity to removal of the anterior clinoid process in internal carotid-posterior communicating artery aneurysm surgery (1989)
    Springer
    Acta neurochirurgica 99 (1989), S. 117-121 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral aneurysm ; internal carotid artery ; anterior clinoid process ; cerebral angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During the last 10 years, we had to resect the anterior clinoid process (ACP) before applying the clip in three of the 70 patients with internal carotid-posterior communicating artery (ICPCom) aneurysms. To reveal the angiographic characteristics in these three patients, we measured the following parameters on carotid angiograms in all 70 patients: 1) the angle between the midline of the skull and the axis of the C 1 segment of the internal carotid artery (ICA) on A-P view (angle A), 2) the angle between the axes of the C1 and C2 segments of the ICA on A-P view (angle B), and 3) the distance between the posterior wall of the carotid “knee” and the proximal aneurysmal neck on lateral view (distance d). The common angiographic features of these three patients were as follows: 1) angle A was larger than 60 degrees, 2) angle B was less than 90 degrees, 3) distance d was less than 10mm, and 4) the posterior communicating artery was of the foetal type. The present results suggest that preoperative angiogram can predict whether or not the ACP should be removed during ICPCom aneurysm surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402319
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  • 8
    Electronic Resource
    Electronic Resource
    Cerebral aneurysms unrelated to arterial bifurcations (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 958-964 
    Details
    ISSN: 0942-0940
    Keywords: Arteriosclerosis ; curvature aneurysms ; haemodynamic stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The majority of saccular cerebral aneurysms arise at arterial branchings; those arising elsewhere are rare. Among 557 saccular cerebral aneurysms surgically treated between 1983 and 1994, 29 (5.2%) were unrelated to arterial divisions. These cases were retrospectively analysed. The ages of the subjects ranged from 6 to 80 years (mean 57); 17 (59%) were female, and 12 (41%) male. Twenty-four (83%) presented with subarachnoid haemorrhage. Seventeen (59%) had a history of hypertension, and ten (34%) had multiple cerebral aneurysms. The most common site was the internal carotid artery (45%), followed by the middle cerebral artery (28%), the vertebrobasilar arteries (17%), and the anterior cerebral artery (10%). The aneurysms were classified in relation to arterial curvature into three groups: dorsal curvature (41%), ventral curvature (10%) and non-curvature (49%). During surgery, sclerotic changes were noted in the arterial wall adjacent to the aneurysms in 14 patients (48%). Five cases (17%) had small thin walled (blisterlike) aneurysms, four of which ruptured during surgery resulting in poor clinical outcomes. We suggest that arteriosclerotic changes in the arterial wall, carotid siphon, and/or local haemodynamic forces are important factors in the development of this type of aneurysms. At surgery, one should bear in mind the possibility of sclerotic or blister-like aneurysms which require special attention to deal with them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411285
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  • 9
    Electronic Resource
    Electronic Resource
    “Nidus sparing sign” on computerized tomography in intracerebral haemorrhage due to a rupture of arteriovenous malformation (1988)
    Springer
    Acta neurochirurgica 95 (1988), S. 102-108 
    Details
    ISSN: 0942-0940
    Keywords: Nidus sparing sign ; lobar intracerebral haemorrhage ; arteriovenous malformation ; computerized tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors investigated the validity of noncontrast computerized tomography (NCCT) to predict the presence of arteriovenous malformations (AVM) as a cause of intracerebral haemorrhage (ICH) in the acute stage. They found a small iso- or slightly hyperdense nodular or tubular defect devoid of haematoma in its periphery on NCCT in 8 of the 13 AVM cases that underwent both NCCT and contrast CT. This CT finding was named “nidus sparing sign” (NSS). This haematoma-free notch was enhanced on contrast infusion and confirmed to correspond to the AVM nidus surgically and pathologically. In one case with negative angiograms, a small AVM was verified histologically within the tissue corresponding to the NSS. The NSS noted on the NCCT could be of great value in case emergency surgery is needed for comatose patients with ICH, particularly lobar ICH, without enough time left to undergo angiography and/or magnetic resonance imaging. Neurosurgeons are able to safely perform an evacuation of the haematoma keeping in mind the possibility of a ruptured AVM and if so, the spatial relationship between the AVM nidus and the haematoma. This might also be a valuable CT sign in deciding whether or not angiography should be undertaken in ICH cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790769
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  • 10
    Electronic Resource
    Electronic Resource
    CVD Synthesis of Tungsten Nitride and lts Deposition Behavior (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 554 (Aug. 2007), p. 65-70 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The synthesis and deposition behavior of tungsten nitrides on a Si(400) or quartzplate were studied using a vertical hot-wall tube reactor. The preparation of the tungsten nitrideby chemical vapor deposition (CVD) is predicted by the sticking probability of tungsten nitrideby calculating the step coverage on the Si(400) engraved with a microtrench of different aspectratios. The CVD deposition was performed at temperatures of 556–1063 K for deposition timesup to 45 min in a gas mixture of WF6–NH3–H2 in Ar and at a total pressures of 5 and 13 Pa.From the XRD analysis, amorphous crystallites were observed at 556 and 673 K but β–W2N(111) was obtained at 790 K. The film thickness of the tungsten nitride linearly increased withthe increasing deposition time at 673 and 790 K without any orientation despite the filmthickness. The sticking probabilities, η, are 0.00044–0.00123 for Si(400) with different aspectratios under the conditions of 5–13 Pa and 10–20 min
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.554.65.pdf
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