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  • 1
    ISSN: 1432-1076
    Keywords: Key words Magnetic resonance imaging  ;  Pituitary gland  ;  Ectopia of the posterior pituitary  ;  Growth hormone deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to validate an association between pituitary size and severity of growth hormone deficiency (GHD) we evaluated the magnetic resonance images (MRI) of 107 children with different causes of short stature. Ninety-one MRIs were evaluable (64 male, 27 female; age: 9.1 ± 3.9 years). The levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3), and tests of GH stimulation and spontaneous secretion, led to the following sub-groups: severe isolated GHD (SIGHD) (GH 〈 7 ng/ml) (n = 21); partial, isolated GHD (GH 7–10 ng/ml) (n = 22); multiple pituitary hormone deficiency (MPHD) (n = 13); neurosecretory dysfunction (n = 10); non-classifiable diagnosis (NC) (n = 13); idiopathic short stature (n = 9); and intra-uterine growth retardation (n = 3). Pituitary height (PHT) was measured and hypoplasia was assumed when PHT was 〈−2 SDS. An ectopic posterior pituitary with missing stalk and a hypoplastic anterior pituitary was present in 12 (57%) SIGHD cases, 12 (92%) MPHD cases and 1 patient from the NC group. An isolated hypoplastic anterior pituitary was observed in 15%−33% of the other groups. PHT (mm; mean, SD) in MPHD (1.7 ± 0.5) was lower than in SIGHD (2.7 ± 1.0, P 〈 0.05), with PHT of both groups being lower than in all the other groups (3.8 ± 0.9, P 〈 0.0001). PHT SDS correlates with IGF-I SDS (r = 0.48, P 〈 0.0001), IGFBP-3 SDS (r = 0.46, P 〈 0.0001) and the highest peaks in tests of GH stimulation and GH spontaneous secretion (r = 0.36, P 〈 0.0001). In contrast to all the other groups, no correlation with age was observed in MPHD and SIGHD. Breech delivery was recorded in up to 26% of patients in all seven groups. Surprisingly, only 1 out of 23 patients with an ectopic posterior pituitary was born by breech delivery, suggesting that ectopia of the posterior lobe is not necessarily related to breech delivery. Conclusion PHT is significantly correlated with GH secretion in several types of short stature. Patients with␣ectopic posterior pituitary, missing stalk and hypoplastic␣anterior pituitary either suffer from SIGHD or MPHD, and this anatomical defect is not necessarily related to breech delivery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 31 (1975), S. 255-263 
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 213 (1988), S. 227-230 
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 32 (1976), S. 1297-1302 
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular Structure 18 (1973), S. 49-58 
    ISSN: 0022-2860
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular Structure 16 (1973), S. 79-88 
    ISSN: 0022-2860
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Communications in mathematical physics 8 (1968), S. 185-203 
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract The edge of the wedge theorem is generalized to the case where one only assumes the existence and equality of the distribution boundary values off ±(z) and all their derivatives on some analytic curveC inR n . Heref ±(z) are holomorphic inR n ±iC, respectively, whereC is a convex cone, andC has its tangent vector inC at every point. Under these assumptions there exists an analytic continuationf(z) holomorphic in some complex neighbourhood of the double cone generated byC. A proof is also given of the connection between the existence of a distribution boundary value and the growth of the holomorphic function near the boundary.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 148 (2000), S. 666-672 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Fetale Tachyarrhythmie ; Elektrophysiologie ; Antiarrhythmische Therapie ; Nicht immunogener Hydrops fetalis ; Key words Fetal tachyarrhythmia ; Electrophysiology ; Antiarrhythmic drug therapy ; Non-immune hydrops fetalis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Fetal supraventricular tachycardia and atrial flutter are life-threatening dysrhythmias, which, untreated, may cause non-immune fetal hydrops and may lead to fetal death. In the literature optimal management and the way of antiarrhythmic maternal and more recently fetal drug therapy remains controversial. The aim of this article is to report on the problems of therapy of fetal tachyarrhythmias and to summarize current knowledge. After diagnosing the arrhythmia with the help of M mode or doppler echocardiography perinatologists, neonatologists and pediatric cardiologists have to decide on the further proceedings individually. The fetus without signs of hydrops can often be treated successfully with digoxin administered to the mother. In fetuses with tachycardia- induced hydrops digoxin is the drug of first choice, too. They, however, need significantly more antiarrhythmic drugs and longer therapy for cardioversion into sinusrhythm, which is achieved less frequently than in fetuses without hydrops. In hydrops patients a further option is direct fetal therapy with drug application into the umbilical vein. Longterm prognosis seems to be excellent regardless of the severity of illness at clinical presentation.
    Notes: Zusammenfassung Hintergrund: Die supraventrikulären Tachykardien und das Vorhofflattern des Fetus sind lebensbedrohliche Rhythmusstörungen, die unbehandelt zu einem nicht immunogenen Hydrops fetalis und frühen Absterben des Fetus führen können. In der Literatur finden sich zahlreiche, oft widersprüchliche Kasuistiken über das Management der Patienten und die Möglichkeiten der antiarrhythmischen maternen und neuerdings auch fetalen Therapie. Ziel dieser Übersicht ist es, die Problematik der Behandlung fetaler Tachyarrhythmien aufzuzeigen und bisherige gesicherte Erkenntnisse zusammenzufassen. Therapie: Nach Diagnosestellung der Arrhythmie mittels Echokardiographie im M-Mode- oder Doppler-Verfahren muß in Zusammenarbeit von Perinatologen, Neonatologen und pädiatrischen Kardiologen über das Prozedere individuell entschieden werden. Feten ohne Zeichen des Hydrops sind mit Digoxin häufig erfolgreich transplazentar zu behandeln. Auch bei Feten mit Tachykardie-bedingtem Hydrops ist Digoxin das Medikament erster Wahl. Sie benötigen jedoch signifikant mehr antiarrhythmische Medikamente und eine längere Therapiedauer bis zur Kardioversion in einen Sinusrhythmus, der seltener als bei Feten ohne Hydrops erreicht wird. Eine weitere Therapieoption bei diesen Patienten ist die direkte fetale Therapie mit Medikamentenapplikation über die Nabelschnurvene. Progose: Die Langzeitprognose der Patienten scheint nach ersten Angaben aus der Literatur unabhängig von der Schwere der Erkrankung bei Diagnosestellung gut zu sein.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 144 (1996), S. 1257-1259 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Jodmangel ; Jodprophylaxe ; Umfrage bei Kinderärzten ; Key words Iodine deficiency ; Iodine prophylaxis ; Survey among paediatricians
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Despite the fact that, in Germany, valid laws allowing unrestricted use of iodine salt are available, iodine deficiency still exists. The foetus, newborns and pubertal children are particularly vulnerable to iodine deficiency. The role of the paediatrician is, therefore, an important one not only in guiding patients but also in disseminating knowledge towards the prevention of iodine deficiency. From the results of our survey, approximately 85 % of German paediatricians are of the opinion that iodine supply in children is unsatisfactory. It emerged that 90 % do hold iodine supplements in children to be necessary, whereas 8 % believe that iodine intake poses a risk to health. The high costs arising from goitre were, on the whole, underestimated. It can, therefore, be concluded that, firstly, there is consensus on the fact that iodine intake is low in Germany, and, secondly, that measures must be taken to improve this situation: The education of the public must continue to be given high priority in aiming to achieve increased intake of iodine salt and in allaying the fears of professionals and lay people.
    Notes: Zusammenfassung Der Jodmangel besteht in Deutschland trotz der gesetzlichen Voraussetzungen für eine breite Verwendung des Jodsalzes weiterhin. Besonders gefährdet durch den Jodmangel ist der Organismus während der Fetal- und Neugeborenenperiode und während der Pubertät. Kinderärzte und Kinderärztinnen spielen deshalb eine große Rolle bei der Aufklärung der Patienten und der Verbreitung der Kenntnisse über den Jodmangel und dessen Prävention in Deutschland. Vor diesem Hintergrund war es nun interessant, zu erfahren, wie die Meinung der Kinderärzte und Kinderärztinnen zum Thema Jodmangel und Jodprophylaxe ist. Nach dem Zufallsprinzip wurden Fragebögen an 600 Kinderärzte und Kinderärztinnen verschickt. 240 Antwortschreiben waren auswertbar. Etwa 85 % der Kinderärzte und Kinderärztinnen in Deutschland halten unseren Umfrageergebnissen zufolge das Jodangebot für Kinder für unzureichend, 90 % sehen ein zusätzliches Jodangebot an Kinder als erforderlich an. Maßnahmen, die zu ergreifen sind, werden angegeben. 8 % der antwortenden Ärzte und Ärztinnen halten dagegen eine Jodidgabe für gefährlich. Der Kostenaufwand, den Jodmangelstrumen verursachen, wird deutlich unterschätzt. Daraus läßt sich schließen, daß ein Konsens über das mangelnde Jodangebot in Deutschland und über die Maßnahmen, die zur Verbesserung der Situation beitragen können, besteht. Es wird jedoch weiterhin eine intensive Aufklärung der Bevölkerung notwendig sein, um eine breite Nutzung des Jodsalzes zu erreichen und unberechtigte Bedenken auch unter Ärzten und Ärztinnen aus dem Weg zu räumen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 79-84 
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The aim of the project BD1 (Biotechnology Data Bank 1) is to improve the data processing for research in biotechnology. In BD1, data of several classes of objects and methods are compiled. A data file conception consisting of object data files, method data files and feature data files was created, which can be easily extended to further classes, and which allows the combination of different classes of features to the same class of objects. There are two main approaches to use BD1: 1. making available informations on certain biotechnological objects, 2. the identification of unknown objects by means of their feature pattern.The microbiological data base and the possibilities of data base search are presented by example of lactic acid bacteria.
    Additional Material: 7 Tab.
    Type of Medium: Electronic Resource
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