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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis of hepatic cavernous hemangioma by fine needle aspiration biopsy under ultrasonic guidance (1990)
    Springer
    Abdominal imaging 15 (1990), S. 39-42 
    Details
    ISSN: 1432-0509
    Keywords: Hepatic hemangioma ; Fine needle aspiration biopsy ; Ultrasonic guidance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Percutaneous aspiration biopsy of the liver using a heparinized 22-gauge needle was performed under ultrasonic guidance in 11 patients with hepatic cavernous hemangioma. Ten (91%) of 11 biopsy specimens obtained were cytologically diagnostic for hemangioma. No indications of malignancy were found. There was no relation between the cytological diagnosis and the location, size, or ultrasonographic findings. No complications were encountered. These findings indicate that cytological examination of the liver by fine needle aspiration biopsy is useful in diagnosing hepatic cavernous hemangioma of any size and in any location, provided optimal route to the lesions is chosen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01888731
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats (1997)
    Springer
    Clinical & experimental metastasis 15 (1997), S. 603-611 
    Details
    ISSN: 1573-7276
    Keywords: azoxymethane ; bombesin ; cancer metastasis ; ginsenoside Rg3 ; intestinal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of concomitant use of bombesin and ginsenoside Rg3 on the incidence of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane were investigated in male inbred Wistar rats. From the start of the experiment, rats were given weekly s.c. injections of azoxymethane (7.4mg/kg body weight) for 10 weeks and s.c. injection of bombesin (40μg/kg body weight) every other day, and from week 20, s.c. injections of ginsenoside Rg3 (2.5 or 5.0mg/kg body weight) every other day until the end of the experiment in week 45. Bombesin significantly increased the incidence of intestinal tumors and cancer metastasis to the peritoneum in week 45. It also significantly increased the labeling index of intestinal cancers. Although administration of a higher dose of ginsenoside Rg3 with bombesin had little or no effect on the enhancement of intestinal carcinogenesis by bombesin, the location, histologic type, depth of involvement, infiltrating growth pattern, labeling and apoptotic indices and tumor vascularity of intestinal cancers, it significantly decreased the incidence of cancer metastasis. These findings indicate that ginsenoside Rg3 inhibits cancer metastasis through activities that do not affect the growth or vascularity of intestinal cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018491314066
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Usefulness of Simple Endoscopic Aspiration Cytology of Pancreatic Juice for Diagnosis of Early Pancreatic Neoplasm (A Prospective Study) (1997)
    Springer
    Digestive diseases and sciences 42 (1997), S. 1796-1803 
    Details
    ISSN: 1573-2568
    Keywords: PANCREATIC NEOPLASM ; PURE PANCREATIC JUICE ; CYTOLOGY ; ENDOSCOPIC RETROGRADE PANCREATOGRAM ; EARLY DIAGNOSIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For detection of early cancer of the pancreas,endoscopic aspiration cytology of pancreatic juicewithout endoscopic retrograde pancreatography wasperformed in 64 consecutive outpatients who had symptoms or findings that suggested pancreatic disease.Patients with positive or suspicious cytologic resultsor abnormal US findings were admitted and underwentdetailed examinations. Positive and suspicious cytologic results were obtained in 2 and 10 patients,respectively. Of those with positive and suspiciouscytologic results, two, and one patient, respectively,were ultimately found to have pancreatic neoplasms. Of these three resected specimens, one was insitu carcinoma and two presented marked atypia. Allpatients were alive with no evidence of recurrence. Nofurther cases of pancreatic neoplasm were found. Complications from the procedure did notdevelop in any patient. This technique is useful in thediagnosis of early neoplasms of the pancreas, because itis simple and safe to perform for outpatients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018842305690
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  • 4
    Electronic Resource
    Electronic Resource
    Endoscopic ultrasonography in diagnosis and staging of pancreatic cancer (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 696-700 
    Details
    ISSN: 1573-2568
    Keywords: endoscopic ultrasonography ; pancreatic cancer ; early diagnosis ; locoregional spread assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The accuracy of endoscopic ultrasonography (EUS) for diagnosis of pancreatic cancers was evaluated in consecutive 232 patients with possible pancreatic cancer, and that for assessment of their locoregional spread was evaluated in 28 patients with pancreatic cancer subjected to pancreatectomy, in comparison with the accuracies of transabdominal ultrasonography (US) and computed tomography (CT). EUS was found to be significantly more accurate than US or CT and was especially useful for detecting small pancreatic cancers of less than 2 cm in diameter. With EUS, pancreatic cancers could be detected as a hypoechoic mass with a relatively unclear margin and irregular internal echoes. EUS was also more sensitive than CT and US for detecting venous and gastric invasions: it was more useful for detecting direct invasion of pancreatic cancers when the tumors were less than 3 cm in diameter. These findings indicate that EUS is an accurate method for diagnosis of pancreatic cancer and assessment of their locoregional spread and is particularly useful for detecting small tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064392
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  • 5
    Electronic Resource
    Electronic Resource
    Clinicopathological features and endoscopic diagnosis of superficial early adenocarcinomas of the large intestine (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 1333-1337 
    Details
    ISSN: 1573-2568
    Keywords: superficial early colorectal cancer ; chromoendoscopy ; de novo cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From October 1987 to March 1991, 21 (8%) superficial early cancers were found among 256 early colorectal cancers (Dukes A and B1). Superficial early cancers were defined as early cancers less than 3 mm in height. These tumors were found scattered throughout the large intestine and were often observed as reddish spots, which were easily overlooked without careful observation. Histologically, 19 (90%) of them were well-differentiated adenocarcinomas, and five (24%) of them reached the submucosal layer. Eighteen (86%) of them were not associated with adenoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296086
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    ras p21 isoprenylation inhibition induces flat colon tumors in Wistar rats (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 70-75 
    Details
    ISSN: 1530-0358
    Keywords: Pravastatin ; ras p21 isoprenylation ; Colon carcinogenesis ; Flat colon tumor ; Azoxymethane ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The effect of pravastatin, an inhibitor ofras p21 isoprenylation, on the gross type of colon tumors induced by azoxymethane was investigated in Wistar rats. METHODS: Rats received ten weekly subcutaneous injections of 7.4 mg/kg body weight of azoxymethane and intraperitoneal injections of 10 or 20 mg/kg body weight of pravastatin every other day until the end of the experiment at Week 45. RESULTS: Administration of pravastatin at both dosages had no significant effect on the incidence of colon tumors but significantly increased the incidence of rats with adenomas only. In contrast to the elevated adenomas in control rats, flat adenomas were significantly more prevalent in rats given pravastatin. Pravastatin at both doses significantly decreased the labeling index, but not the apoptotic index, of elevated adenomas, whereas it significantly decreased the labeling index but increased the apoptotic index of flat adenomas. Administration of pravastatin at both dosages also significantly decreased the amounts of membrane-associatedras p21 in colon tumors. CONCLUSIONS: These findings suggest that theras oncogene may be closely related to the development of adenocarcinomas from adenomas and the development of elevated or polypoid tumors of the colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02237247
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