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  • 1
    Electronic Resource
    Electronic Resource
    Effects of naloxone on methamphetamine and apomorphine stereotypy and on haloperidol catalepsy in rats (1984)
    Springer
    Psychopharmacology 82 (1984), S. 237-240 
    Details
    ISSN: 1432-2072
    Keywords: Naloxone ; Methamphetamine ; Apomorphine ; Haloperidol ; Stereotypy ; Catalepsy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with the opiate antagonist naloxone, at 1.25–5 mg/kg, increased the intensity of methamphetamine stereotypy, had no effect (over a range of 0.3125–5 mg/kg) on apomorphine stereotypy, and antagonized haloperidol catalepsy in rats at 1.25–5 mg/kg. It is suggested that naloxone, by blocking the opiate receptors located on the nigro-striatal and mesolimbic dopamine (DA) nerve terminals, releases the DA systems from endogenous inhibition, presumably caused by endogenous opiate systems, and thereby potentiates methamphetamine stereotypy and antagonizes haloperidol catalepsy. However, the possibility that naloxone might have affected methamphetamine stereotypy and haloperidol catalepsy by modulating the activity of the central noradrenergic and GABAergic systems, which are reported to influence dopaminergically mediated behaviours, also needs to be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427781
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Head-twitch response induced by ergometrine in mice: Behavioural evidence for direct stimulation of central 5-hydroxytryptamine receptors by ergometrine (1986)
    Springer
    Psychopharmacology 88 (1986), S. 275-278 
    Details
    ISSN: 1432-2072
    Keywords: Ergometrine ; 5-HT receptor antagonists ; Clomipramine ; p-Chlorophenylalanine ; p-Chloramphetamine ; Fenfluramine ; Head twitches ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ergometrine (2.5–80 mg/kg IP) induced head twitches in mice. Pretreatment with cyproheptadine (1.5 and 3 mg/kg), methysergide (5 and 10 mg/kg) and (−)-propranolol (2.5 and 5 mg/kg) significantly decreased the number of head twitches induced by ergometrine. Pretreatment with p-chlorophenylalanine (100 mg/kg/day×4 days) and clomipramine (5 and 10 mg/kg) significantly decreased the number of head twitches induced by fenfluramine (10 mg/kg) and p-chloramphetamine (5 mg/kg) but had no significant effect on the number of head twitches induced by ergometrine. The results indicate that ergometrine induces head twitches in mice by directly stimulating central 5-hydroxytryptamine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180824
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of L-histidine and promethazine on apomorphine and amantadine stereotypy in rats (1983)
    Springer
    Psychopharmacology 79 (1983), S. 372-374 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Amantadine ; Stereotyped behaviour ; L-Histidine ; Promethazine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with L-histidine, a precursor of brain histamine, and promethazine, a H1 receptor blocker, failed to modify apomorphine-induced stereotyped behaviour in rats. In contrast, pretreatment with L-histidine significantly decreased the intensity of amantadine stereotypy while pretreatment with promethazine significantly increased the intensity of amantadine stereotypy in rats. The results suggest that drugs which influence central histaminergic mechanisms are effective only in modifying the stereotyped behaviour induced by the indirectly-acting DA agonist amantadine, and fail to modify the stereotyped behaviour induced by apomorphine, a directly-acting DA agonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433422
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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