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Digitale Medien

Changes in atrial natriuretic factor and plasma renin activity in dogs infected withTrypanosoma brucei (1992)

Ndung'u, J. M. ; Wright, N. G. ; Jennings, F. W. ; [weitere]

Springer

Parasitology research 78 (1992), S. 553-556

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Details

ISSN: 1432-1955

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract When beagle dogs were infected withTrypanosoma brucei, a marked reduction in the plasma concentration of atrial natriuretic factor (ANF) occurred in the terminal stage of the disease during weeks 3 and 4. At the same time there was an increase in plasma renin activity (PRA) after infection. Ultrastructural studies of the atria of these dogs demonstrated a reduction in ANF granules. The changes in ANF and PRA occurred in association with severe pancarditis and the development of heart failure. By impairing the ability of the heart and kidneys to regulate blood volume, the alterations in ANF and PRA could be involved in the pathogenesis of heart failure inT. brucei-infected dogs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00936451

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