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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 39-40 (Dec. 1994), p. 199-202 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Fourteen stratiform, stratabound and vein-type sulphide occurrences in the Upper Allochthon of the Central–North Norwegian Caledonides have been studied for their sulphur, oxygen and hydrogen isotope composition. Depositional ages of host rocks to the stratabound and stratiform sulphide occurrences range from 590 to 640 Ma. The sulphides and their host rocks have been affected by polyphase deformation and metamorphism with a peak temperature of 650 °C dated to 432 Ma. A total of 104 sulphide and 2 barite samples were analysed for δ34S, 16 whole-rock and quartz samples for δ18O and 12 samples of muscovite for δD. The overall δ34S values range from −14 to +31‰ with the majority of sampled sulphides lying within a range of +4 to +15‰. In most cases δ34S within each hand specimen behaves in accordance with the equilibrium fractionation sequence, δ34Sgn〈δ34Scp〈δ34Ssph〈δ34Spy. A systematic increase in δ34S from the vein sulphides (−8‰) through schist/amphibolite-hosted (+6‰) and schist-hosted (+7 to +12‰) to dolomite-hosted (+12 to +31‰) occurrences is documented. The δ34S averages of the stratiform schist-hosted sulphides are 17 to 22‰ lower than in the penecontemporaneous seawater sulphate. The Bjørkåsen (+4 to +6‰) occurrence is a volcanogenic massive sulphide (VMS) transitional to sedimentary massive sulphide (SMS), exhalative, massive, pyritic deposit of Cu–Zn–Pb sulphides formed by fluids which obtained H2S via high-temperature reduction of seawater sulphate by oxidation of Fe2+ during the convective circulation of seawater through underlying rock sequences. The Raudvatn, volcanic-hosted, disseminated Cu sulphides (+6 to +8‰) obtained sulphur via a similar process. The Balsnes, stratiform, ‘black schist’-hosted, pyrite–pyrrhotite occurrence (−6 to −14‰) is represented by typical diagenetic sulphides precipitated via bacteriogenic reduction of coeval (ca. 600 Ma) seawater sulphate (+25 to +35‰) in a system open to sulphate supply. The δ34S values of the Djupvik–Skårnesdalen (+7 to +12‰), Hammerfjell (+5 to 11‰), Kaldådalen (+10 to +12‰) and Njallavarre (+7 to +8‰) stratiform, schist-hosted, massive and disseminated Zn–Pb (±Cu) sulphide occurrences, as well as the stratabound, quartzite-hosted, Au-bearing arsenopyrite occurrence at Langvatnet (+7 to +11‰), suggest that thermochemically reduced connate seawater sulphate was a principal sulphur source. The Sinklien and Tårstad, stratabound, dolomite- and dolomite collapse breccia-hosted, Zn (±Cu–Pb) sulphides are marked by the highest enrichment in 34S (+20 to +31‰). The occurrences  are assigned to the Mississippi-Valley-type deposits. High δ34S values require reduction/replacement of contemporaneous (ca. 590 Ma) evaporitic sulphate (+23 to +34‰) with Corg-rich fluids in a closed system. The Melkedalen (+12 to +15‰), stratabound, fault-controlled, Cu–Zn sulphide deposit is hosted by the ca. 595 Ma dolomitised Melkedalen marble. The deposit is composed of several generations of ore minerals which formed by replacement of host dolomite. Polyphase hydrothermal fluids were introduced during several reactivation episodes of the fault zone. The positive δ34S values with a very limited fractionation (〈3‰) are indicative of the sulphide-sulphur generated through abiological, thermochemical reduction of seawater sulphate by organic material. The vein-type Cu (±Au–W) occurrences at Baugefjell, Bugtedalen and Baugevatn (−8 to −4‰) are of hydrothermal origin and obtained their sulphur from igneous sources with a possible incorporation of sedimentary/diagenetic sulphides. In a broad sense, all the stratiform/stratabound, sediment-hosted, sulphide occurrences studied formed by epigenetic fluids within two probable scenarios which may be applicable separately or interactively: (1) expulsion of hot metal-bearing connate waters from deeper parts of sedimentary basins prior to nappe translation (late diagenetic/catagenetic/epigenetic fluids) or (2) tectonically driven expulsion in the course of nappe translation (early metamorphic fluids). A combination of (1) and (2) is favoured for the stratabound, fault-controlled, Melkedalen and Langvatnet occurrences, whereas the rest are considered to have formed within option (1). The sulphides and their host rocks were transported from unknown distances and thrust on to the Fennoscandian Shield during the course of the Caledonian orogeny. The displaced/allochthonous nature of the Ofoten Cu–Pb–Zn ‘metallogenetic province’ would explain the enigmatically high concentration of small-scale Cu–Pb–Zn deposits that occur only in this particular area of the Norwegian Caledonides.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of orthopaedic surgery & traumatology 3 (1993), S. 313-315 
    ISSN: 1432-1068
    Keywords: Hanche ; Fracture ; Ostéosynthèse ; Infection ; Staphylocoques ; Hip ; Fracture ; Osteosynthesis ; Infection ; Staphylococci
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During the last decade a decrease in postoperative infections in femoral neck fracture osteosynthesis was noted which led us to review all femoral neck fractures for infection. In a retrospective series of 1894 femoral neck fractures, the majority of which were included in other limited prospective studies, a total of 15 deep infections were diagnosed (0.8%). Staph. aureus was the most common bacterium cultured, and the diagnosis was established more than 4 months postoperatively in 9 of the patients. A total of 658 of the 1894 patients, who had pre- or peroperative tetracycline administration for measuring bone turnover, had two deep infections (0.3%). Among the remaining 1236 patients without antibiotic prophylaxis, 13 deep infections were diagnosed (1.0%). This difference suggests considering antibiotic prophylaxis in femoral neck fracture osteosynthesis. Eight of the infections led to THR, usually two-stage ; no signs of recurrent infection ensued, and the hip function of these patients was restored. The remaining 7 patients had Girdlestone procedures, also without recurrent infection, but with inferior functional outcome.
    Notes: Résumé On a noté pendant les dix dernières années une chute du nombre d'infections postopératoires dans les ostéosynthèses des fractures du col fémoral, ce qui nous a amené à revoir tous les cas infectés de ces fractures. Lors d'une série rétrospective de 1 894 fractures du col fémoral, dont la plupart étaient dans d'autres études prospectives limitées, on a diagnostiqué un total de 15 infections profondes (0,8 %). Le staphylocoque doré était la bactérie la plus souvent en cause ; le diagnostic était établi plus de 4 mois après l'intervention chez 9 des patients. 658 patients sur les 1 894, auxquels il avait été administré des tétracyclines per-opératoires pour mesurer le renouvellement osseux, ont présenté deux infections profondes (0,3 %). Parmi les 1 236 patients restants, sans antibioprophylaxie, on a comptabilisé 13 infections profondes (1,0 %). Cette différence incite à recommander la prophylaxie antibiotique dans l'ostéosynthèse de la fracture du col du fémur. Huit des infections ont conduit à une arthroplastie totale de la hanche, habituellement en deux étapes ; il n'y eut pas de récidive d'infection, et la fonction de la hanche fut rétablie chez ces patients. Les 7 patients restants ayant subi une résection de type Girdlestone, n'eurent aucune récidive d'infection, mais leur résultat fonctionnel fut moins bon.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 28 (1985), S. 311-315 
    ISSN: 1432-1041
    Keywords: acetylator phenotype ; isoniazid ; age distribution ; sex distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 310 Swedish patients, the distribution of acetylator phenotype was studied by determination of the half-life of isoniazid (INH T1/2). The expected bimodal distribution was found in the complete study group, but was not always clearly apparent after subgrouping for age and sex. Mean INH T1/2 was higher in males and tended to increase with age. The difference in INH T1/2 between males and females was small in younger individuals (below 46 years of age) and showed a gradual increase with age. In older individuals (above 65 y) mean INH T1/2 was 42 min longer in males than in females. In the females, mean INH T1/2 was relatively constant in all age groups. The effect of age on acetylator phenotype, previously reported by other workers, appears to have been confirmed but only in males. It may be influenced by concurrent treatment for certain diseases.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 16 (1988), S. 287-297 
    ISSN: 1432-1017
    Keywords: Ribonuclease T1 ; protein dynamics ; molecular dynamics ; protein-nucleic acid interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Molecular dynamics simulations in vacuum and with a water sphere around the active site were performed on the 2′GMP-RNase T1 complex. The presence of water led to the maintenance of the 2′-GMP-RNase T1 interactions as compared to the X-ray structure, including the hydrogen bonds implicated in the enzyme-inhibitor recognition process. The sidechain of His92 in the molecular dynamics water simulation, however, hydrogen bonds directly to the phosphate of 2′GMP in contrast to the X-ray structure but in support of the role of that residue in the enzyme's catalytic mechanism. Fluctuations of activesite residues are not strongly influenced by water, possibly owing to the exclusion of water by the bound 2′GMP, which did show an increase in mobility. Analysis of the 2′GMP-RNase T1 interactions versus time reveal an equilibrium fluctuation in the presence of water, leading to a less favorable 2′GMP-RNase T1 interaction energy, suggesting a possible relationship between picosecond fluctuations and inhibitor dissociation occurring in the millisecond time domain.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1017
    Keywords: Key words Transcription factors ; Glucocorticoid receptor ; DNA response elements ; Protein-DNA complexes ; Cooperative binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Molecular dynamics (MD) simulations of the estrogen receptor DNA-binding domain (ERDBD) as a dimer in complex with its DNA response element (ERE) show a significant difference in both structure and dynamics, compared to a MD simulation of monomeric ERDBD bound to its half-site response element (EREH). The C-terminal zinc binding domain (ZnII), including a region (helix II) which is in a helical conformation in ERE-(ERDBD)2, is considerably more flexible in EREH-ERDBD than in the dimeric complex. In EREH-ERDBD, all helical hydrogen bonds in helix II are broken and the entire ZnII region is detached from a hydrogen bonding network that in ERE-(ERDBD)2 connects to other parts of the protein as well as to the DNA. The regions that become flexible in EREH-ERDBD are identical to the regions where the NMR solution structure of free ERDBD is poorly ordered. This strongly suggests that dimerisation of ERDBD is required for ordering of the ZnII region and that monomeric binding to DNA is not sufficient for the ordering. This contrasts to the glucocorticoid receptor DNA-binding domain (GRDBD) which has essentially the same mobility (uniform and limited), regardless of whether it is free as a monomer in solution, bound as a monomer to its half-site response element or in a dimeric complex with the full response element. The hydrogen bonding network that connects ZnII with other parts of the protein and to DNA is almost identical in ERDBD and GRDBD. However, in GRDBD there is also a serine (in the N-terminal zinc coordinating region) with a central role in this network, connecting to the ZnII region. This serine is replaced by a glycine in ERDBD and we suggest that this substitution is sufficient for destabilisation of the network, thus leading to a more flexible ZnII region, which becomes ordered first upon forming a complex with another ERDBD and DNA.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 32 (1987), S. 493-498 
    ISSN: 1432-1041
    Keywords: theophylline ; erythromycin ; drug interaction ; aminophylline ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg·kg−1) over 1 h, followed by a maintenance infusion (0.5 mg·kg−1·h−1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant. Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication. We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 30 (1986), S. 421-425 
    ISSN: 1432-1041
    Keywords: nimodipine ; subarachnoid haemorrhage ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Patients with a ruptured supratentorial aneurysm undergoing early surgery after the subarachnoid haemorrhage were treated postoperatively with nimodipine to prevent delayed ischaemic dysfunction. It was given first as a continuous intravenous infusion 2 mg/h (mean dose 0.5 µg/kg/min) for at least 7 days, and then orally (45 mg × 6) for at least a further 7 days. During the i.v. infusion, the mean plasma concentration was 26.6±1.8 ng/ml. The plasma clearance ranged from 0.57 to 1.77 l/kg/h and was negatively correlated with the age of the patient. Immediately prior to successive oral doses, the mean plasma concentration was 13.2 ng/ml (range〈3–38.8 ng/ml). The peak level was usually found after 1 h; it ranged from 7.0–96.0 ng/ml. Mean bioavailability was 15.9%. The nitropyridine metabolite was found in measurable concentrations only after oral treatment with nimodipine. In some cases, the concentration of metabolite exceeded that of the parent compound. The three patients investigated who developed delayed ischaemic dysfunction had plasma concentrations well within the range in patients who did not, so it seems unlikely that the therapeutic failure could be attributed to individual deviations in the pharmacokinetics of the drug.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 740 (1983), S. 460-465 
    ISSN: 0167-4781
    Keywords: (Yeast) ; Anticodon loop ; Conformation transition ; Fluorescence ; Spermine ; tRNA^P^h^e
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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