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  • 1
    Electronic Resource
    Electronic Resource
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts, 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 6 (1996), S. 0 
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an attempt to create uniform nationwide guidelines for the management of all stages of endometrial carcinoma, and to limit the use of adjuvant radiation therapy in stage I disease to high-risk patients only, a protocol was developed by the Danish Endometrial Cancer group (DEMCA). From September 1986 through August 1988, 1214 women in Denmark with newly diagnosed carcinoma of the endometrium have been treated according to this protocol. This figure represents all endometrial carcinomas diagnosed in Denmark during this 2-year period. The primary treatment was total abdominal hysterectomy and bilateral salpingo-oophorectomy and no preoperative radiation therapy was delivered. In 1039 cases no macroscopic residual tumor and/or microscopic tumor tissue in the resection margins was found following surgery. Based on surgery and histopathology, these patients were classified as: P-stage I low-risk (grade 1 & 2 and 〈inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:1048891X:IJG06010038:les" location="les.gif"/〉 50% myometrial invasion), P-stage I high-risk (grade 1 & 2 and〉 50% myometrial invasion, and grade 3), P-stage II and P-stage III (Group 1). Distribution was as follows: P-I low-risk 641 patients, P-I high-risk 235, P-II 105 and P-III (Group 1) 58 patients. No postoperative radiation therapy was given to P-I low-risk cases. P-I high-risk, P-II, and P-III (Group 1) cases received external radiation therapy. Recurrence rate at 68–92 months follow-up was 45/641 (7%) in P-I low-risk, 36/235 (15%) in P-I high-risk, 30/105 (29%) in P-II, and 27/58 (47%) in P-III (Group 1) cases. Fifteen of 17 vaginal recurrences in P-I low-risk cases were salvaged (mean observation time 61 months).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Scientific Publications
    International journal of gynecological cancer 3 (1993), S. 0 
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cancer antigen 125 (CA 125) was measured in 17 patients with ovarian carcinoma before their primary operation and during the first week after surgery. The purpose was to correlate the change in the antigen level with the patient’s survival. Before surgery normal (16–30 U ml−1 CA 125 values were measured in four patients and 13 had increased (75–11.356 U ml−1) antigen concentrations. After surgery the marker increased to 104–931% of the preoperative level in five patients. In 12 patients the post-operative antigen level decreased to 20–96% of the preoperative level. In seven of these patients CA 125 increased without exceeding the preoperative level, after the initial postoperative fall. Thus, the CA 125 level during the first week after primary operation of ovarian cancer patients seems to be influenced by other variable factors besides a reduced amount of tumor tissue. Therefore, an investigation of the correlation between the change in the CA 125 concentration within the first week after surgery and the survival of the patient cannot be performed for the time being.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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