ISSN:
1524-475X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Introduction: Oral mucosa heals faster with less scar than skin, but its mechanism has not been elucidated enough. We have studied whether there are any differences in the dynamic study of the bFGF expression in vivo during wound healing between oral mucosa and skin. Methods: Male Wistar rats were anesthetized, and a 3 mm circular exisional wound was made on the dorsum skin and intrabuccal mucosa of each rat. At days 0,1,3,5,7 and 10 post-wounding,wounds were harvested, and embedded in OCT. From photographs of the wounds, each wound area was measured by means of NIH images. Also, for histological study, sections were stained haematoxylin and eosin, and for immunohistochemical study, sections were stained with anti-bFGF antibody. Results: Oral wounds contracted significantly faster than skin. Regenerated skin appeared at day 1 post-wounding in oral wounds, but at day 3 in skin. Re-epithelialization was completed on day 5 post-wounding in oral, but on day 7 in skin. The number of bFGF-positive cells gradually increased in the granulation tissue, and the peak of positive cells in oral was observed on day 5 post-wounding, while that in skin on day 7. Conclusion: Oral mucosa healed faster than skin. The peak of bFGF expression was faster in oral mucosa than skin. It was thougt that bFGF effects the differences during wound healing between oral mucosa and skin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1067-1927.2004.abstractz.x
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