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  • 1
    ISSN: 1432-0533
    Keywords: Key words Amyloid ; Apolipoprotein E ; Prion ; Squirrel monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction of various amyloid precursors and apolipoprotein E (apoE) is important for Congophilic amyloid formation. As for cerebral amyloidoses, although the correlation between amyloid β protein (Aβ) and apoE in Alzheimer’s disease (AD) has been clarified, the interaction of prion protein isoform (PrPsc) and apoE in several types of prion diseases (PDs) has not been examined in detail. ApoE colocalization has been confirmed in Congophilic PrPsc plaques, but to clarify the participation of apoE in the early stage of PDs, apoE deposition in immature lesions without Congophilic amyloid in PDs needs to be examined. In the present study two squirrel monkeys were inoculated with mouse PrPsc derived from sheep scrapie, and showed signs of severe spongiform degeneration. These lesions were immunohistochemically characterized as patchy perivacuolar and diffuse synaptic lesions without Congophilic amyloid. The central portion of the assemblies involving a few patchy perivacuolar lesions was detected by methenamine silver staining and appeared as a plaque-like lesion. ApoE was colocalized in all the plaque-like lesions and in half of the patchy perivacuolar lesions, but not in any diffuse synaptic lesions. These immunohistochemical characteristics indicated that apoE colocalization occurred in moderate mature lesions in PDs, and apoE might play an important role in the aggregation of PrPsc after a conformational change from cellular PrP isoform to PrPsc.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 19 (1989), S. 167-168 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A study was performed to establish the value of a computed radiography (CR) system in neonatal respiratory distress syndrome (RDS). CR images obtained with various X-ray doses were compared with the images of a standard film-screen system. The image quality of CR taken with about one half radiation exposure, was comparable to that of the standard high speed film-screen combination. The use of CR could lead to a significant reduction in radiation in the neonatal I.C.U.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 20 (1989), S. 48-51 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed the chest x-ray (CXR) findings and clinical courses of 129 patients with Kawasaki disease and found abnormal CXR findings in 14.7% of the patients. Reticulogranular pattern was the most frequent abnormality (89.5%), while peribronchial cuffing (21.1%), pleural effusion (15.8%), atelectasis (10.5%) and air trapping (5.3%) were also seen. In each of these patients, CXR abnormalities appeared within 10 days after the onset of illness. In the group with abnormal CXR findings, a statistically significant increase was noted in duration of fever, incidence of adventitious sounds, serum CRP levels and incidence of coronary arterial lesions and pericardial effusion, as compared with the group having normal CXR findings. The pathological basis of these CXR changes is not clear, since no biopsy or autopsy specimen was obtained from these patients, none of these patients showed definite heart failure, it is difficult to consider that abnormal CXR findings were due to heart failure. On the other hand, physical signs and previous pathological reports suggested that the causes of abnormal CXR findings were lower respiratory tract inflammation and/or pulmonary arteritis.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of histiocytosis-X (Langerhans cell histiocytosis) in infants with an anterior mediastinal mass containing punctate calcifications on CT.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 22 (2001), S. 401-410 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We assess the potential of future electron-positron linear colliders operating in the $e^\pm\gamma$ mode in detecting charged Higgs bosons with mass around and larger than the top quark mass, using Compton back-scattered photons from laser light. We compare the pair production mode, $e^-\gamma\to e^- H^+H^-$ , to a variety of channels involving only one charged Higgs scalar in the final state, such as the tree-level processes $e^-\gamma\to \nu_e H^- \Phi^0 $ ( $\Phi^0=h^0,H^0$ and $A^0$ ) and $e^-\gamma\to \nu_e f\bar f H^-$ ( $f=b,\tau$ and $\nu_\tau$ ) as well as the loop-induced channel $e^-\gamma\to \nu_e H^-$ . We show that, when the charged Higgs boson mass is smaller than or comparable to half the collider energy, $\sqrt s_{ee}\gtrsim 2M_{H^\pm}$ , single production cross sections are of the same size as the pair production rate, whereas, for charged Higgs boson masses larger than $\sqrt s_{ee}/2$ , all processes are heavily suppressed. In general, production cross sections of charged Higgs bosons via $e^\pm\gamma$ scatterings are smaller than those induced at an $e^+e^-$ collider and the latter represents a better option to produce and analyse such particles.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-5922
    Keywords: portal vein aneurysm ; AV malformation ; vascular malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Portal vein aneurysm (PVA) includes focal dilatation of the portal vein, and was formerly thought to be a rare disease. We report a 46-year-old man with chronic aggressive hepatitis and intrahepatic portal vein ancurysm communicating with the hepatic vein. Hemangiomas in the liver and intracranial arteriovenous malformation (AVM) were also found. To our knowledge, this is the first report of a case of PVA in a patient with congenital intracranial AVM. As the PVA in this patient communicated with the hepatic vein, and as hemangiomas in the liver and intracranial AVM were also present, the pathogenesis in this patient seems to have been congenital anomaly of the vasculature.
    Type of Medium: Electronic Resource
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