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  • 1
    Electronic Resource
    Electronic Resource
    Molecular cloning of cDNA for rat glycine methyltransferase
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 124 (1984), S. 44-50 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(84)90913-6
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  • 2
    Electronic Resource
    Electronic Resource
    Reliability of Low-Temperature Poly-Si Thin-Film Transistors (2003)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 93 (June 2003), p. 43-48 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/26/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.93.43.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    The lipoprotein lipase activator, NO-1886, suppresses fat accumulation and insulin resistance in rats fed a high-fat diet (2000)
    Springer
    Diabetologia 43 (2000), S. 875-880 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Hormone sensitive lipase, obesity, respiratory quotient, skeletal muscle, visceral fat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in rats fed a high-fat diet.¶Methods. Male, Sprague-Dawley rats were fed for 10 weeks on a chow diet or a high-fat diet with, or without, NO-1886 (50 mg · kg–1· day–1). Weight gain, fat accumulation and both hormone-sensitive and lipoprotein, lipase activities were measured. Insulin action was assessed by the euglycaemic hyperinsulinaemic clamp and metabolic rate/substrate utilisation by open-circuit respirometry.¶Results. Compared with chow-fed controls, a high-fat diet increased weight gain, an effect lessened by NO-1886 [weight gain (g): chow, 37 ± 3, high-fat, 222 ± 9; high-fat + NO-1886, 109 ± 6, all groups differed p 〈 0.001]. A similar pattern existed for fat accumulation [visceral fat (g): chow, 35.9 ± 3.2; high-fat, 81.9 ± 6.6; high-fat + NO-1886, 52.3 ± 4.7, p 〈 0.01 high-fat vs the other groups]. A high-fat diet induced whole-body insulin resistance (clamp glucose infusion rate: 4.8 ± 1.3 mg · kg–1· min–1 vs 10.6 ± 1.1 for the chow group, p 〈 0.01) with NO-1886 lessening this effect (8.3 ± 0.5, p 〈 0.05 vs high-fat). The 24-h respiratory quotient was lower in the high-fat + NO-1886 group (0.825 ± 0.010) compared with high-fat alone (0.849 ± 0.004, p 〈 0.05). A high-fat diet increased lipoprotein and hormone-sensitive, lipase activities in epididymal fat, an effect not altered by NO-1886. In myocardium and skeletal muscle a high-fat diet lowered lipoprotein lipase activity, an effect lessened by NO-1886.¶Conclusion/interpretation: Lipoprotein lipase activators could have potential benefits for the treatment of obesity by increasing fat utilisation. [Diabetologia (2000) 43: 875–880]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051464
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  • 4
    Electronic Resource
    Electronic Resource
    MR imaging of cervical carcinoma: comparison among T2-weighted, dynamic, and postcontrast T1-weighted images with histopathological correlation (1997)
    Springer
    Abdominal imaging 22 (1997), S. 103 -107 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Uterus, cervix, neoplasm—Magnetic resonance, diagnosis. [xm [fs99]
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To identify the reasons for misdiagnosis of the degree of stromal invasion by uterine cervical cancer with various magnetic resonance sequences. Methods: T2-weighted, dynamic, and postcontrast T1-weighted images were obtained in the sagittal plane in 20 patients with uterine cervical cancer. After evaluating these sequences for the degree of stromal invasion, histologic specimens were directly correlated with these images. Results: The degree of stromal invasion was correctly diagnosed in 15 of the 20 cases on T2-weighted images, in 12 on dynamic images, and in eight on postcontrast T1-weighted images. All misdiagnoses were due to overestimation. Histologically, peritumoral stroma showed inflammation or edema in two patients, whereas no histological abnormality was found in the other patients. A hyperintense rim, i.e., a peritumoral enhanced ring-shaped structure, was observed on the enhanced images of five patients. The hyperintense rim corresponded to the periphery of the tumor in three patients and to the cervical stroma in two patients. Conclusion: T2-weighted images permitted the most accurate evaluation of stromal invasion by uterine tumors. Overdiagnosis may be due to an abnormal intensity of the cervical stroma, which was observed more frequently on dynamic and postcontrast T1-weighted images than on T2-weighted images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900151
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of increase in prostaglandin F2-alpha after recirculation in global ischemic rat brains (1987)
    Springer
    Acta neuropathologica 75 (1987), S. 62-68 
    Details
    ISSN: 1432-0533
    Keywords: prostaglandin F2α ; Immunohistochemistry ; Ischemia ; Recirculation ; Carbodiimide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical localization of prostaglandin F2α (PG F2α) was studied in 24 rats. In 21 rats, global brain ischemia was produced for 5 min by Pulsinelli's method. Prior to decapitation, 13 were recirculated for 5 min, while the remaining eight were not. Three recirculated rats were pretreated with indomethacin before the occlusion. Hypotension was induced during the occlusion to 40–50 mm Hg of mean arterial blood pressure in 11 rats including those unrecirculated, recirculated and pretreated with indomethacin. Three normal rats without occlusion of arteries served as control. The brains were snap frozen and 10-μm cryostat sections were incubated in rabbit anti-PG F2α serum and stained by the indirect immunofluorescence method after fixation in carbodiimide and in Zamboni's solution. Positive staining for PG F2α was noted mainly in pial vessels in normal and ischemic rats both with and without hypotension. The rats recirculated without hypotensive ischemia revealed a positive reaction in the walls of pial and parenchymal vessels. All rats recirculated after the hypotensive occlusion showed positive staining in blood vessels, in the cytoplasm of neurons (especially in hippocampi) and in the interfascicular oligodendrocytes. The above results indicate that recirculation after ischemia results in an increase in PG F2α in parenchymal vessels, neurons and oligodendrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686794
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  • 6
    Electronic Resource
    Electronic Resource
    Rapid increase of prostaglandin F2-alpha in neurons after subarachnoid hemorrhage in rats: an immunohistochemical study (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 621-628 
    Details
    ISSN: 1432-0533
    Keywords: Subarachnoid hemorrhage ; Prostaglandin F2-alpha ; Hippocampus ; Purkinje cell ; Intracranial hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of subarachnoid hemorrhage (SAH) with various degrees of increase in intracranial pressure (ICP) on the staining of prostaglandin F2-alpha (PG F2α) were studied in rat brains. SAH was produced in 18 rats by injection of 0.18–0.20 ml of autologous arterial blood/100 g body weight into the cisterna magna. By changing the speed of injection, the ICP was transiently increased by 346±68 (mean±S.D.) mm Hg in eight rats (including three pretreated with indomethacin), by 200±42 mm Hg in five rats, and by 6±4 mm Hg in the other five. Three rats injected with the same volume of mock cerebrospinal fluid (CSF) with ICP increased by 217±67 mm Hg and five normal rats without injection served as controls. All animals were decapitated 15 min after injection. The cryosections were stained for PG F2α using an indirect immunofluorescence method. Positive staining for PG F2α was noted only in pial vessels in all normal and mock-CSF-injected rats. In SAH rats with ICP increased by 6±4 mm Hg, there was a positive reaction in hippocampal neurons and Purkinje cells as well as blood vessels. SAH rats with higher ICP showed stronger PG F2α staining in the above areas, as well as in cerebellar granule cells. All rats pretreated with indomethacin showed a smaller increase in staining. The above results indicate that subarachnoid blood clots per se produce a rapid increase of PG F2α in neurons and blood vessels of both cerebrum and cerebellum, and that this increase is augmented by intracranial hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691289
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  • 7
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of transient increase in prostaglandin F2-alpha after recirculation in global ischemic rat brains (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 496-501 
    Details
    ISSN: 1432-0533
    Keywords: Prostaglandin F2-alpha ; Immunohistochemistry ; Transient increase ; Hippocampus ; Purkinje cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The changes in prostaglandin F2-alpha (PG F2α) staining over 3 days of recirculation in both fore-and hindbrains were studied. Five minutes of global ischemia was produced in 24 rats by Pulsinelli's method with hypotension around 50 mm Hg of mean arterial blood pressure. Eight rats (including three pretreated with indomethacin) were recirculated for 5 min, three for 1 h, five for 2 h and five for 3 days. Five normal rats without occlusion of vessels served as controls. The brains were snap frozen. Ten-micrometer cryosections were stained for PG F2α by the indirect immunofluorescence method after fixation in carbodiimide and in Zamboni's solution. Positive staining for PG F2α was noted in pial vessels in all normal and ischemic rats. Recirculated rats revealed the strongest reaction at 5 min after recirculation in blood vessels and in neuronal cytoplasm (especially in hippocampi and in Purkinje cells). The intensity of staining was markedly reduced after 1 h. Rats pretreated with indomethacin showed less increase in staining. The above results indicate that recirculation after ischemia produces a transient increase in PG F2α in blood vessels and neurons of both fore- and hindbrains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686389
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  • 8
    Electronic Resource
    Electronic Resource
    Antheridium development of Sargassum fulvellum and S. kjellmanianum (1976)
    Springer
    Marine biology 38 (1976), S. 163-168 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The antheridium development of Sargassum fulvellum Ag. and S. kjellmanianum Yendo was investigated. The characteristics of meiosis were observed at the first division of the antheridium in both species. The chromosome number observed was 32 in both species. Six divisions were observed during the development of the antheridium, and the first two divisions were meiotic. 64 nuclei were formed in each antheridium, and cytoplasmic cleavage occurred after the final division. The manner of antheridium development in both species is similar to that already reported from Japan for 7 species of the genus Sargassum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390769
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  • 9
    Electronic Resource
    Electronic Resource
    On the antheridium development of Sargassum micracanthum and S. ringgoldianum (1974)
    Springer
    Marine biology 27 (1974), S. 21-26 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The antheridium development of Sargassum micracanthum Yendo and S. ringgoldianum Harvey was investigated with the iron-alum haematoxylin staining method and the aceto-carmine squash technique. Synapsis occurred at the prophase in the first division while the chromatin threads were still contracted, and the nucleus passed through diakinesis. The first two divisions in the antheridium were meiotic, and the four other divisions (mitosis) followed without cytokinesis. In S. micracanthum and S. ringgoldianum, 31 and 32 chromosomes respectively were counted at prometaphase in the first division, 64 sperm nuclei were organized in the final division. After the final division cytoplasmic cleavage occurred, and 64 sperm cells were finally completed in an antheridium. Centrosomes and asters could not be discerned at any of the divisions, because of limited magnification facilities. A peculiarly shaped small body was observed at the prophase of the first division, but not thereafter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394756
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  • 10
    Electronic Resource
    Electronic Resource
    Tensile testing of microfabricated thin films (1997)
    Springer
    Microsystem technologies 3 (1997), S. 117-121 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  Mechanical properties of titanium thin films of 0.5 μm thickness and aluminum thin films of 1.0 μm thickness, microfabricated by magnetron sputtering, were measured by using a novel tensile machine. These thin films are difficult to handle because they are fragile, so the thin film specimens were fabricated by using semiconductor manufacturing technology in a silicon frame to protect them. The test section of these specimens was 300 μm in width and 1400 μm in gauge length. By gripping the thin film specimen with a new device using a micrometer, it could be mounted on the tensile machine easily. The stress-strain diagrams of both thin films were measured continuously in the atmosphere at room temperature. The experimental results indicated that the titanium thin film and the aluminum thin film had a smaller breaking elongation although they had a larger tensile strength than bulk pure titanium and bulk pure aluminum, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050067
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