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  • 1
    Electronic Resource
    Electronic Resource
    Beeinflussung Der Tubocurarinlähmung Durch Calcium-Ionen Vom Blutwege Her (1951)
    Springer
    Journal of molecular medicine 29 (1951), S. 784-784 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483279
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma glutathione peroxidase after selenium supplementation in patients with reduced selenium state (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 138-140 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Supplementation ; Plasma ; Glutathione peroxidase ; Glutathione S-transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The plasma glutathione peroxidase (GSHPx) activity was measured in normal adults and children and in patients with reduced selenium state because of dietary treatment of metabolic diseases (phenylketonuria or maple-syrup-urine disease) before and after selenium supplementation. Besides GSHPx (measured with t-butyl hydroperoxide, cumene hydroperoxide and hydrogen peroxide as acceptor substrates) the activity of glutathione S-transferase was estimated in plasma. Plasma GSHPx activity in healthy children was significantly lower than in healthy adults. In 11 dietetically treated patients with phenylketonuria or maple-syrup-urine disease the plasma GSHPx was reduced to about 17% of the values of healthy children of the same age. No glutathione S-transferase activity could be found in plasma of children in normal or reduced Se state. During administration of yeast rich in Se (200μg Se/d) for 90 days 2 healthy adults showed no significant change of plasma GSHPx activity. During Se supplementation (75–100μg Se/d) for 120–163 days 5 dietetically treated patients with PKU or MSUD exhibited a significant increase of plasma GSHPx activity within 2 days. The values reached a plateau after 1 to 3 weeks of supplementation and remained at this level within the following 4 to 5 months. Therefore, the activity of plasma glutathione peroxidase can be used as an indicator of short-term changes of selenium intake in selenium deficient individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441140
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  • 3
    Electronic Resource
    Electronic Resource
    Hair zinc of young children from rural and urban areas in North Rhine-Westphalia, Federal Republic of Germany (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 179-183 
    Details
    ISSN: 1432-1076
    Keywords: Zinc ; Hair ; North Rhine-Westphalia ; Atomic absorption spectrophotometry ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hair zinc levels were estimated by atomic absorption spectrophotometry in 474 children, aged 3–7 years, from 11 kindergartens in a highly industrialized and polluted area (Duisburg) and 8 kindergartens in a rural area of North Rhine-Westphalia. The mean hair zinc level amounted to 118 μg/g, increasing between the 4th and 7th year of life. At all ages the values from the urban toddlers were lower than from rural toddlers, and in both regions they were higher in winter than in summer. Children with frequent upper respiratory tract infections (〉6 infections/year) showed significantly lower zinc hair values, independent of their age. Low hair zinc values (below 70 μg/g) were frequently found, raising the question as to whether this is a normal, age-related phenomenon, or whether it indicates a suboptimal zinc status of young children from North Rhine-Westphalia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442218
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  • 4
    Electronic Resource
    Electronic Resource
    Glutathione peroxidase and glutathione S-transferase activity of platelets (1983)
    Springer
    European journal of pediatrics 140 (1983), S. 244-247 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Supplementation ; Platelets ; Glutathione peroxidase ; Glutathione S-transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A low Se intake in dietetically treated patients with phenylketonuria (PKU) or maple syrup urine disease (MSUD) leads to a marked reduction of the platelet glutathione peroxidase activity (GSHPx). The mean value amounted to 2.0 U/1011 platelets with t-butyl hydroperoxide (t-BOOH) (2.2 U/1011 with H2O2) in patients and 5.8 U/1011 with t-BOOH (5.4 U/1011 with H2O2) in the control children. After Se supplementation with yeast rich in Se (dose: 135 μg Se/m2) the GSHPx activities rapidly increased. They reached a plateau after 2–3 weeks and remained there during the following 15–20 weeks of supplementation. After the cessation of supplementation there was a slow decrease, the values reached a low plateau after 24 weeks. In addition platelet glutathione S-transferase (GSHTf) was estimated with 1-chloro-2,4-dinitrobenzene. No significant difference between the values in healthy and dietetically treated patients in a low or normal Se state was observed. GSHTf did not exhibit peroxidase activity and did not show a compensatory increase when Se dependent GSHPx activity was low. The patients do not reveal clinical signs of disturbed platelet function. GSHPx may act in platelets via lipoxygenase on the prostaglandin pathway. The physiologic consequence of altered arachidonate metabolism, when GSHPx is deficient in platelets, remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443370
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  • 5
    Electronic Resource
    Electronic Resource
    Single-dose toxicokinetics of aluminum in the rat (1992)
    Springer
    Archives of toxicology 66 (1992), S. 700-705 
    Details
    ISSN: 1432-0738
    Keywords: Aluminum ; Toxicokinetics ; Rat ; Parenterals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The toxicokinetics of aluminum (Al) in male Wistar rats was studied after single intragastric (IG) doses of 1000 and 12000 μg Al/kg and intravenous (IV) doses of 10, 100, 1000, and 12000 μg Al/kg. Serial blood samples, daily samples of urine and feces as well as brain, liver, kidney, spleen, quadriceps muscle, and femur samples were collected. Al was measured by atomic absorption spectrometry. Al blood profiles after IV doses were adequately described by a two-compartment open model. Al toxicokinetics was dose dependent and appeared to plateau at 12000 μg/kg. At IV doses between 10 and 1000 μg/kg the terminal half-life of elimination from whole blood (t1/2β) increased from 29.9±7.8 to 209.3±32.6 min, and the total body clearance (CL) decreased from 2.45±0.64 to 0.28±0.03 ml min−1 kg−1. Following an IV bolus of 10 and 100 μg/kg the administered Al was recovered completely from urine (94.4%±9.9% and 98.5%±3.2%). Twenty-nine days after the IV dose of 1000 μg/kg daily renal excretion decreased to baseline values while only 55.1%±8.0% of the dose was excreted. Nineteen days after the single IV dose of 1000 μg/kg Al accumulated in liver (28.1±7.7 versus 1.7±0.5 μg/g of control rats) and spleen (72.5±21.1 versus 〈0.4 μg/g). After the single 1000 μg/kg IG dose no absorption of Al was detectable. The IG dose of 12000 μg/kg resulted in a maximum blood Al level of 47.9±12.4 μg/l after 50 min. The blood concentration time curve fitted a one-compartment open model with a half-life of absorption of 28.2±3.6 min and a t1/2β of 81.2±20.2 min. Cumulative renal Al excretion was 0.18%±0.10% of the dose and oral bioavailability was 0.02%. Seventeen days after the 12000 μg/kg IG dose the Al content in femur samples was increased (2.7±1.3 versus 0.6±0.4 μg/g). In no case was fecal elimination of incorporated Al observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972620
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  • 6
    Electronic Resource
    Electronic Resource
    Charakterisierung der Cholinesterasen in verschiedenen Geweben der Schleie (Tinca vulgaris) und des Kaninchens (1966)
    Springer
    Journal of comparative physiology 52 (1966), S. 260-275 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Summary The properties of cholinesterases in homogenates of various tissues (brain, skeletal muscle, stomach) of the tench (Tinca vulgaris) and of the rabbit were investigated by means of the Warburg method. 1. The cholinesterases from all tench tissues investigated are more specific than those obtained from corresponding rabbit tissues. 2. In all cases a bell-shaped activity-pS-relationship is obtained. Maximal hydrolysis of acetylcholine occurs at 4×10−3 m. The cholinesterases in tench tissues show higher Michaelis constants than those in rabbit tissues. 3. Lower concentrations of neostigmine and physostigmine are necessary for the inhibition of rabbit brain Cholinesterase than for the inhibition of Cholinesterase from tench brain. 4. For rabbit tissue Cholinesterase the optimal reaction temperature is 37° C. For tench tissue Cholinesterase, the following optimal reaction temperatures were determined: brain 34,5°, skeletal muscle 32°, stomach muscle 25° C. No difference was observed for the Q10-values of cholinesterases from tissues of the two animals. 5. The temperature-dependent characteristics of the cholinesterases remain unaffected by adaptation of the living tenches at 5° C and at 20° C.
    Notes: Zusammenfassung Mit der Warburg-Methode wurden Eigenschaften der Cholinesterasen in Homogenaten verschiedener Gewebe (Gehirn, Skeletmuskulatur, Magen) der Schleie (Tinca vulgaris) und des Kaninchens untersucht. 1. Die Cholinesterasen in allen Geweben der Schleie sind spezifischer als die in den entsprechenden Geweben vom Kaninchen. 2. Alle Aktivitäts-pS-Kurven haben einen glockenförmigen Verlauf; das Maximum der Acetylcholin-Spaltung liegt bei einer Konzentration von 4×10−3 m. Die Michaelis-Konstanten der Cholinesterasen sind in den Geweben der Schleie höher als in den Kaninchen-Geweben. 3. Neostigmin und Physostigmin hemmen die Cholinesterase im Kaninchen-Gehirn in geringeren Konzentrationen als die Cholinesterase im Schlei-Gehirn. 4. Die optimale Reaktionstemperatur beträgt für die Cholinesterasen in den Kaninchen-Geweben 37° C. Die Cholinesterasen der Schleie haben ihre Optima bei 34,5° (Gehirn), 32° (Skeletmuskel) und 25° C (Magenmuskulatur). Die Q10-Werte beider Tiere unterscheiden sich nicht. 5. Durch Adaptation lebender Schleie an Wassertemperaturen von 5 und 20° C erfolgt keine Änderung der temperaturabhängigen Charakteristika der Cholinesterasen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427712
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  • 7
    Electronic Resource
    Electronic Resource
    Untersuchungen über Peristaltik am Darm der Schleie (Tinca vulgaris) (1968)
    Springer
    Journal of comparative physiology 58 (1968), S. 153-170 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Der Darm der Schleie (Tinca vulgaris) enthält glatte und quergestreifte Muskulatur. Am Trendelenburgschen Präparat des Schleiendarmes können durch Erhöhung des intraluminalen Druckes peristaltische Bewegungen der glatten Ring- und Längsmuskulatur ausgelöst werden. Durch eine pharmakologische Analyse des Peristaltikreflexes wird untersucht, ob die zahlreichen intramuralen Ganglienzellen des Schleiendarmes, deren Bedeutung bisher noch völlig unklar ist, am Zustandekommen des Reflexes beteiligt sind. 1. Auf intraluminale Druckerhöhung (ca. 3–5 cm Wassersäule) antworten glatte Längs- und Ringmuskulatur nach einer Latenzzeit von etwa 3 min mit synchron verlaufenden, rhythmischen Kontraktionen. Dauer der einzelnen Kontraktionen: 48–60 sec. Kraft: Längsmuskulatur ca. 0,5–2,0 g; Ringmuskulatur ca. 1–3 cm Wassersäule. Die Druckreizbeantwortung erfolgt graduell. 2. Die quergestreifte Darmmuskulatur ist am Ablauf der peristaltischen Bewegungen nicht beteiligt. 3. Acetylcholin und Physostigmin verstärken den Reflex, Atropin und Adrenalin hemmen ihn. 4. In kleinen Dosen haben d-Tubocurarin und Hexamethonium hemmende, in größeren Dosen fördernde Wirkungen auf den peristaltischen Reflex. 5. Nikotin verstärkt zunächst die Peristaltik und hemmt sie später. Die erregende Wirkung des Nikotins läßt sich durch hohe Dosen von Hexamethonium unterdrücken. 2. 1,1-Dimethyl-4-phenylpiperazonium-jodid regt die Peristaltik an, Procain hemmt sie. Diese Befunde sprechen dafür, daß die Peristaltik des Schleiendarmes auf einem regelrechten Reflex beruht, in dessen Bahn Ganglienzellen eingeschaltet sind.
    Notes: Summary The gut of the tench (Tinca vulgaris) contains both smooth and striated muscle. Peristaltic movements of the smooth circular and longitudinal muscles may provoked upon increasing pressure in the lumen of the isolated tench gut preparation, obtained according to Trendelenburg. By means of a pharmacological analysis of the peristaltic reflex it has been investigated whether the numerous intramural ganglion cells of the tench gut (of which the physiological role remains unknown until now) participate in the occurrence of this reflex. 1. After a latency of about 3 min an increase of pressure within the lumen by 3–5 cm H2O provoked synchronic, rhythmical contractions of the circular and longitudinal smooth muscles. The singular contractions lasted for 48–60 sec. Contractile force: longitudinal muscle approx. 0.5–2.0 g; circular muscle about 1–3 cm H2O. The response to increased pressure in the lumen occurs gradually. 2. The striated muscle elements in the gut do not participate in the peristaltic movements. 3. The reflex is enhanced by both acetylcholine and physostigmine. The reflex is inhibited by atropine and by adrenaline. 4. The reflex is inhibited by low doses of d-tubocurarine and hexamethonium. High doses of the latter two drugs enhance the peristaltic reflex. 5. After an initial increase of the reflex nicotine inhibits peristaltic movements. The initial, enhancing effect of nicotine may be abolished by hexamethonium. 6. 1,1-Dimethyl-4-phenylpiperazonium-iodide reinforces peristaltic movements, whereas procaine inhibits them. Our results suggest that the peristaltic movements of the tench gut are caused by a genuine reflex. Ganglionic cells are obviously involved in the reflex pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302632
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  • 8
    Electronic Resource
    Electronic Resource
    Einfluß der Badtemperatur und der Adaptationstemperatur auf die Kontraktionen des isolierten Darmes der Schleie (Tinca vulgaris) (1968)
    Springer
    Journal of comparative physiology 58 (1968), S. 171-184 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung An isolierten Dünndarmstücken von Schleien (Tinca vulg.) wurde untersucht, welchen Einfluß die Temperatur des Organbades (10 und 30° C) und die Adaptationstemperatur der lebenden Fische (5, 16 und 20°) auf die Kontraktionshöhe und die Kontraktionszeit der quergestreiften und der glatten Darmmuskulatur ausüben. Jeweils maximale Kontraktionen wurden hervorgerufen durch elektrische Reizung (30/sec) mit kurzen (1 msec) oder langen (10 msec) Rechteckimpulsen, sowie durch Zusatz von Acetylcholin zum Organbad (10-5 g/ml). Quergestreifte Muskulatur 1. Die Kontraktionshöhen nach elektrischer Reizung waren bei hoher Badtemperatur geringer als bei niedriger. Dieses Verhalten hing nicht von der Adaptationstemperatur ab. 2. Die Kontraktionshöhen nach Acetylcholin im kalten und im warmen Bad unterschieden sich bei Därmen von kaltadaptierten Schleien nicht. Sie waren hingegen bei Därmen von warmadaptierten Fischen im warmen Bad größer als im kalten Bad. Mit steigender Adaptationstemperatur nahmen die Kontraktionshöhen bei niedriger Badtemperatur ab, bei hoher Badtemperatur zu. 3. Die Kontraktionszeit nach elektrischer Reizung konnte nicht bestimmt werden. Nach Acetylcholin zeigt sich weder eine eindeutige Abhängigkeit von der Badtemperatur noch von der Adaptationstemperatur. Glatte Muskulatur 1. Die Kontraktionshöhen nach elektrischer Reizung waren bei Därmen von kaltadaptierten Schleien in der Wärme kleiner als in der Kälte. Bei Därmen von warmadaptierten Fischen bestand hingegen kein Unterschied. Mit zunehmender Adaptationstemperatur wuchsen die Kontraktionshöhen im warmen Bad an, im kalten Bad veränderten sie sich nicht 2. Die Kontraktionshöhen nach Acetylcholin verhielten sich hinsichtlich ihrer Beeinflußbarkeit durch die Bad- und die Adaptationstemperatur ähnlich wie nach elektrischer Reizung. 3. Die Kontraktionszeiten nach elektrischer Reizung waren stets im warmen Bad kürzer als im kalten Bad. Mit steigender Adaptationstemperatur nahmen sie im kalten Bad ab; im warmen Bad veränderten sie sich nicht. 4. Nach Acetylcholin wurden analoge Änderungen der Kontraktionszeiten bei Variation der Bad und der Adaptationstemperatur beobachtet wie bei elektrischer Reizung. Aus den Versuchen folgt, das die Kontraktionen der quergestreiften und der glatten Muskulatur des Darmes der Schleie in vitro vom Adaptationszustand der lebenden Fische beeinflußt werden. Durch die Adaptation werden neben nervösen hauptsächlich muskuläre Vorgänge betroffen.
    Notes: Summary In isolated ileum pieces of the tench (Tinca vulgaris) the influence of either the temperature of the organ bath (10° and 30° C) and of the adaptation temperature (5°, 16° and 20° C) on both striated and smooth intestinal muscle was investigated. The amplitude and also the time between the stimulus and the maximal height of the contractions (“time of contraction”) were established. Maximal contractions were provoked upon electrical stimulation (30/sec for 6 sec) with either short (1 msec) or long (10 msec) rectangular impulses and also upon addition of acetylcholine (10−5 g/ml) to the organ bath. Striated muscle 1. At high bath temperature the contractions after electrical stimulation were smaller than at lower temperature. Adaptation temperature did not influence this phenomenon. 2. The amplitudes of acetylcholine-induced contractions in either a cold or warm bath were not different for the ilea of cold-adapted tenches. If the tenches had been adapted to higher temperatures, however, the acetylcholine-induced contractions of the isolated ilea were more pronounced in a warm bath. Increasing adaptation temperature led to lower contraction amplitudes at low bath temperature, and to higher amplitudes at high bath temperature. 3. After electrical stimulation the “time of contraction” could not be determined. After treatment with acetylcholine a clearcut dependency of the “time of contraction” upon either bath temperature or adaptation temperature could not be established. Smooth muscle 1. For the ilea of cold-adapted tenches the contraction amplitudes obtained upon electrical stimulation were lower at high bath temperatures than in the cold. For ilea of fishes, adapted at higher temperatures, no difference could be demonstrated. The contraction amplitudes in a warm bath increased with rising adaptation temperatures. In a cold bath, the adaptation temperature did not influence the contraction amplitude. 2. The amplitudes of the acetylcholine-induced contractions were influenced similarly as those provoked upon electrical stimulation. 3. After electrical stimulation the “time of contraction” proved shorter in a warm bath than in a cold one. This difference was not influenced by the adaptation as such. Increasing adaptation temperature provoked a reduction of the “time of contraction” in a cold bath; in a warm bath the adaptation temperature did not influence this time. 4. The “time of contraction” of acetylcholine-induced contractions were influenced by the adaptation and bath temperature in a similar manner as the contractions, obtained upon electrical stimulation. The results indicate that in vitro, the contractions of striated and smooth muscle of the tench gut may be influenced by the adaptation temperature of the living fish. Apart from nervous processes, adaptation mainly influences muscular phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302633
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of cadmium on carbonic anhydrase activity and hemoglobin content of rat testes (1976)
    Springer
    Archives of toxicology 37 (1976), S. 39-46 
    Details
    ISSN: 1432-0738
    Keywords: Cadmium ; Carbonic anhydrase ; Hemoglobin ; Blood ; Testes ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die bei Säugetieren durch Cadmium (Cd) hervorgerufenen Hodenschäden beruhen angeblich auf einer Hemmung der Carboanhydratase (CAH). Da Cd dosisabhängig die Hodendurchblutung beeinflußt, könnte jedoch durch eine Verminderung der Zahl CAH-reicher Erythrocyten eine Hemmung der CAH im Hoden vorgetäuscht werden. Wir bestimmten deshalb CAH-Aktivitäten und Hämoglobin (Hb)-Gehalt im Blut und im Hoden von unbehandelten und Cd-behandelten Sprague-Dawley-Ratten. Entsprechende Untersuchungen wurden an Ratten-Hoden durchgeführt, die vorher über die a. testicularis perfundiert worden waren. Die Ratten erhielten Cd intraperitoneal als CdCl2 jeweils in Einzeldosen von 1,5, 3,0 und 5,0 mg Cd2+/kg Körpergewicht. 1. Die Untersuchungen an perfundierten Hoden zeigten deutlich, daß die im Hodengewebe bestimmten CAH-Aktivitäten nicht einer Hoden-CAH sondern vielmehr der Erythrocyten-CAH zuzuordnen sind. 2. Bei den Cd-behandelten Ratten beobachteten wir kurze Zeit (0,25–1,0 h) nach der Cd-Zufuhr zunächst reversible Durchblutungsänderungen. Sie bestanden in Abhängigkeit von der Cd-Dosis sowohl in einer vorübergehenden Abnahme (1,5 mg Cd2+/kg) als auch in einer Zunahme (3,0 bzw. 5,0 mg Cd2+/kg) des Hb-Gehaltes im Hoden. 3. Unabhängig von diesen geringfügigen Durchblutungsänderungen kam es später (14–24 h nach 1,5 mg Cd2+/kg, 7–14 h nach 3,0 mg Cd2+/kg und 1–3 h nach 5,0 mg Cd2+/kg) zu den bekannten hämorrhagischen Hodenveränderungen mit einer starken Zunahme des Hb-Gehaltes und der CAH-Aktivität. 4. Anhand der Korrelationen zwischen CAH-Aktivität und Hb-Gehalt im Blut und im Hoden konnte eine Hemmung der CAH als primäre Ursache der Cd induzierten Hodenschäden ausgeschlossen werden.
    Notes: Abstract The cadmium-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activities and hemoglobin (Hb) content were determined in blood and testes of untreated and Cd-treated Sprague-Dawley rats as well as in testes perfused via the testicular artery. Cd was intraperitoneally applied as CdCl2 in single doses of 1.5, 3.0, and 5.0 mg Cd2+/kg b.w., respectively. 1. The experiments on perfused testes clearly demonstrated that the CAH activities originate from erythrocytes rather than from a tissue located enzyme. 2. The alterations in blood circulation occurring shortly (0.25–1.0 h) after the Cd administration were characterized by a dose-dependent, transient decrease (1.5 mg Cd2+/kg) as well as an increase (3.0 and 5.0 mg Cd2+, respectively) of the Hb content in the testes. 3. Independent of these minor alterations in a later state (14–24 h after 1.5 mg Cd2+/kg, 7–14 h after 3.0 mg Cd2+/kg, and 1–3 after 5.0 mg Cd2+/kg), Cd induced the well known hemorrhagic alterations of the testes with a high increase of Hb content and CAH activity. 4. By means of the correlations between CAH activities and Hb content in blood and testes an inhibition of the CAH by Cd as the primary cause for the tissue damage of the testes could largely be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00353353
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  • 10
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    Electronic Resource
    Hemmung der Cholinesterase-Aktivitäten von Erythrocyten, Ventrikelmuskulatur und Gehirn von Meerschweinchen durch subchronische und akute Vergiftung mit Diisopropylphosphorofluoridat (DFP) und ihre Reaktivierbarkeit durch Obidoxim (1970)
    Springer
    Archives of toxicology 26 (1970), S. 102-116 
    Details
    ISSN: 1432-0738
    Keywords: Diisopropylfluorophosphate ; Acute and Chronic Poisoning ; Therapy with Obidoxime ; Reactivation of Cholinesterase in Various Tissues ; Diisopropylphosphorofluoridat ; Akute und subchronische Vergiftung ; Therapie mit Obidoxim ; Reaktivierbarkeit der ChE verschiedener Gewebe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Meerschweinchen wurde der zeitliche Verlauf der ChE-Hemmung in Erythrocyten, Ventrikelmuskulatur und Gehirn bei subchronischer und akuter DFP-Vergiftung untersucht und die Reaktivierbarkeit der ChE dieser Gewebe nach subcutaner Injektion von Obidoxim geprüft. Bei beiden Vergiftungsarten ergaben sich Unterschiede hinsichtlich des Ausma\es und des zeitlichen Verlaufes der ChE-Hemmung zwischen den drei Geweben. Während der subchronischen Vergiftung durchläuft die ChE-Hemmung bei den Erythrocyten ein Maximum, bei der Ventrikelmuskulatur und dem Gehirn hingegen stellt sie sich kumulativ auf einen Endwert ein. — Die ChE des Gehirns werden durch Obidoxim weder bei der subchronischen noch bei der akuten Vergiftung reaktiviert. Die Reaktivierbarkeit der Erythrocyten-ChE ist bei beiden Vergiftungsarten wesentlich besser als die der ChE in der Ventrikelmuskulatur. Letztere können durch Obidoxim nur innerhalb eines kürzeren Zeitraumes reaktiviert werden als die der Erythrocyten.
    Notes: Summary The time course of inhibition of cholinesterase (ChE) was studied in erythrocytes, ventricular muscle and brain of guinea pigs during chronic and acute poisoning with DFP. The reactivation of ChE in these tissues following subcutaneous injection of obidoxime was also tested. In both kinds of poisoning, considerable differences in degree and time course of ChE-inhibition were observed in the three types of tissue studied. Whereas the ChE-inhibition in erythrocytes achieved a maximum and then subsided, there was a cumulative increase of inhibition leading to a maximal value which was maintained in both ventricular muscle and brain. The ChE of the brain could not be reactivated by obidoxime in either chronic or acute poisoning. In both types of poisoning, the reactivation of ChE in erythrocytes was substantially better than in cardiac muscle. The reactivation by obidoxime in the latter tissue was of shorter duration than in erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577796
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