Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1106
    Keywords: Reticular formation ; Thalamo-cortical recruiting system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In lightly nembutalized cats, effects of high frequency (60–100/sec) repetitive stimulation of the midbrain reticular formation (RF) were tested upon the thalamo-cortical (T-C) neurones which project from the anterior ventral (VA) nucleus of the thalamus and its vicinities to the parietal association cortex and convey impulses responsible for cortical recruiting and spindling-like responses. 2. Tonic maintained or rhythmic grouped firings of the T-C neurones recorded as extracellular units with microelectrode in the thalamus were in the majority suppressed by high frequency RF stimulation during and often for a short time after the stimulation, and they showed later tonic discharges for many seconds or minutes. Intracellular recording from the T-C neurones revealed hyperpolarizing potential changes corresponding to the suppression on high frequency RF stimulation. Field potential analysis in the VA nucleus indicated that the hyperpolarization is ascribed at least in part to IPSPs elicited in the T-C neurones. Responses in some other types of thalamic neurones to the RF stimulation were exemplified to be compared and related with those of the T-C neurones. 3. Desynchronization of the parietal electrocorticogram coincided with the suppression of the T-C neurones and lasted for the time of the later tonic discharges, which contrasted with the rhythmic grouped discharges of the T-C neurones in association with recruiting and spindling-like responses of the cortex. Relations between the thalamo-cortical recruiting system and the ascending reticular activating system were discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 22 (1975), S. 87-96 
    ISSN: 1432-1106
    Keywords: Thalamus ; Cortex ; Recruiting response ; Spindling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The thalamic neurones sending their axons to the parietal association cortex (middle suprasylvian gyrus) and receiving monosynaptic excitation from the cerebellar (interpositus or lateral) nucleus were recorded with microelectrodes extracellularly and intracellularly around the anterior ventral (VA) nucleus of the thalamus in cats. Such thalamic neurones are known to carry exclusively the impulses responsible for superficial thalamo-cortical (T-C) responses in the parietal cortex, being called superficial T-C neurones (see Sasaki et al., 1972a, b). 2. Repetitive (6–9/sec) stimulation of the centrum medianum-parafascicular complex (CM) or the intralaminar nuclei (IL) of the thalamus elicited grouped spike discharges of the neurone in synchronization with the recruiting responses in the parietal cortex. The grouped discharges usually preceded the respective cortical responses by several milliseconds. Numbers of the spikes in the grouped discharges increased and decreased as the recruiting responses waxed and waned on the repetitive stimulation. 3. The superficial T-C neurones also showed similar grouped discharges in synchronization with spindling-like, surface-negative cortical responses which occurred spontaneously or were evoked by single thalamic stimulation. 4. It was concluded that the superficial T-C neurones can convey impulses for recruiting responses and spindling-like responses from the thalamus directly to the cerebral cortex. They are supposed to constitute the final T-C pathway of the neuronal circuits of the recruiting system, i.e., non-specific T-C projection system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-1106
    Keywords: Association cortex ; Cerebellar cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Responses evoked in the cerebellar cortex by stimulation of the parietal association cortex (rostral portions of the middle suprasylvian gyrus) were recorded and analysed in cats, and were compared with those by stimulation of the motor cortex (anterior sigmoid gyrus). 2. The parietal stimulation elicited early mossy fibre and late climbing fibre responses in the cerebellar cortex. The mossy fibre responses appeared at a latency of 2.0–2.5 msec and predominantly in the lateral (hemispherical) part of the contralateral cerebellum (mainly crus I, crus II and paramedian lobules). Cutting of the inferior cerebellar peduncle produced little or no influence upon the mossy fibre responses, which suggests that the mossy fibre responses are mediated chiefly by the pontine nuclei. 3. The climbing fibre responses were recorded at a latency of 17–19 msec and markedly in the contralateral intermediate and medial parts of IV–VI lobules. The responses were easily suppressed by anaesthesia and depended on the conditions of experimental animals. The unstable appearance of the responses and their longer latencies than those of the climbing fibre responses due to stimulation of the motor cortex imply indirect pathways from the parietal association cortex to the inferior olive. 4. The predominant projection of the parietal-induced mossy fibre responses to the lateral part of the cerebellum was compared with the mossy fibre projection from the motor cortex and was discussed as an important component in the cerebrocerebellar loops.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 37 (1979), S. 115-125 
    ISSN: 1432-1106
    Keywords: Association cortex ; Parvocellular red nucleus ; Inferior olive
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stimulation of the parietal association cortex as well as the frontal motor cortex elicited clearly extracellular unitary activities or field potentials in the ipsilateral inferior olive in the cat. The parietal-induced responses came out generally at a longer and more variable latency than the frontal-induced ones. This suggested the existence of an indirect pathway from the parietal association cortex to the inferior olive. The recording sites for the parietal-induced responses were located not only in the dorsal lamella but also in the ventral lamella of the principal olive and in the medial accessory olive. Such olivary sites were exclusively in the rostral half of the inferior olive, and these areas in the olive were considered to give projection fibres predominantly to the hemispherical parts of the cerebellar cortex (neocerebellum). Small neuronal cells were labelled with horseradish peroxidase (HRP) homolaterally in the midbrain tegmentum, after HRP was injected through recording glass microelectrodes into the inferior olive where only the parietal-induced responses were evidently recorded. These small cells were distributed in the rostral one-third of the red nucleus and/or around the adjacent midbrain reticular formation close to the lateral border of the red nucleus. In referring to recent anatomical and physiological data, such small neurones labelled with HRP could be identified as the parvocellular red nucleus neurones. The present results indicate the existence of the parieto-rubro-olivary pathway system in the cat and suggest, in association with our previous studies, that the parvocellular red nucleus neurones participate in control of highly co-ordinated posture and movement predominantly through the neocerebellum.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 24 (1976), S. 495-507 
    ISSN: 1432-1106
    Keywords: Cerebellocerebral projection ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Responses evoked by stimulation of the cerebellar and thalamic nuclei were recorded by microelectrodes introduced at various depths in the cerebral cortex of monkeys (Macaca mulatta) under light Nembutal anaesthesia. 2. Stimulation of the medial (fastigial) cerebellar nucleus produced, at a latency of 4–5 msec, deep thalamo-cortical (T-C) responses (surface positivedeep negative potentials) mainly in the medial part of the precentral gyrus (area 4, “motor area for hindlimb”) and in the superior parietal gyrus (area 5) on both contralateral and ipsilateral sides to the nucleus stimulated. 3. Stimulation of the lateral (dentate) cerebellar nucleus elicited, at a latency of about 3 msec, superficial T-C responses (surface negative-deep positive potentials) predominantly in the lateral part of the precentral gyrus (area 4, “motor area for forelimb and face”) and in the rostromedial part of the gyrus (area 6, premotor area) on the contralateral side. 4. Stimulation of the interpositus cerebellar nucleus set up superficial T-C responses chiefly in the motor area between those influenced by the medial and the lateral cerebellar nucleus stimulation and also in the premotor area on the contralateral side. 5. The respective areas responsive to the medial, interpositus and lateral nucleus stimulation overlapped considerably each other in the motor cortex. 6. Comparison of the responses in the cortex induced by stimulation of the cerebellar and thalamic nuclei indicated different relay portions in and around the VA-VL region of the thalamus for the superficial and the deep T-C responses respectively. 7. Functional implications of the results were discussed in referring to the cerebellocerebral projections in cats.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 31 (1978), S. 31-42 
    ISSN: 1432-1106
    Keywords: Motor cortex ; Caudate nucleus ; Cerebellum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Stimulation of the caudate nucleus (Cd) was found to evoke early mossy fibre (MF) and late climbing fibre (CF) responses in fairly wide areas of the cerebellar cortex in cats. Points capable of eliciting the cerebellar responses were situated exclusively in the head portion of the nucleus. These responses showed a close resemblance to those induced by stimulation of the medial part of the anterior sigmoid gyrus (ASG) both in their contours and in their distributions. 2. There was a remarkable interaction between the Cd- and the medial ASG-induced field potentials in the pontine nuclei. When conditioned by the Cd stimulation at significantly short time intervals, the field potentials evoked by the medial ASG stimulation were more remarkably suppressed than those by the lateral ASG stimulation. 3. Field potentials or extracellular unitary activities in the inferior olive elicited by the Cd stimulation were closely related to those evoked by the medial ASG stimulation both in their responsiveness and in their topographical localizations. 4. When the cortical motor area had been ablated 10–14 days previously, the Cd stimulation elicited no responses in the cerebellar cortex. 5. From these findings, it was indicated that the Cd receives collaterals of the cortico-pontine and/or the cortico-olivary axons that originated almost exclusively from the neurones in the medial ASG (area 6). This suggested the existence of a common innervation of the basal ganglia and the cerebellar systems by the premotor area of the cerebral cortex.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1106
    Keywords: Cerebro-cerebellar projection ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Responses in the cerebellar cortex induced by stimulation of several areas of the cerebral cortex were recorded and identified electro-physiologically to be due to mossy fibre and climbing fibre volleys, and their distributions were explored in the anterior and the posterior lobes of the cerebellum in monkeys. Early mossy and late climbing fibre responses at latencies of 4–5 and 15–18 msec respectively were recorded in certain areas of the cerebellar cortex. They were usually predominant on the contralateral side to the stimulation. 2. Stimulation of the lateral part of the motor cortex (forelimb and face area) evoked mossy and climbing fibre responses mainly in the ansoparamedian lobules and in the caudal part of the anterior lobe (including lobulus simplex) of the cerebellar cortex, stimulation of the medial part of the motor cortex (hindlimb area) provoked the responses predominantly in the rostral part of the anterior lobe, and that of the intermediate part (areas for trunk and proximal parts of the extremities) induced the responses preponderantly in the middle part of the anterior lobe of the cerebellum. 3. Stimulation of the parietal association cortex (area 5) elicited mossy and climbing fibre responses chiefly in the anterior lobe of the cerebellum. The premotor cortex innervates wide areas of the anterior and posterior lobes on both contralateral and ipsilateral sides. The frontal association cortex showed the projections on even wider areas of the cerebellar cortex, although the responses were relatively small in size. 4. The results were compared with those obtained in cats and considered in referring to the cerebro-cerebellar loops in monkeys.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 40 (1980), S. 203-208 
    ISSN: 1432-1106
    Keywords: Cortico-caudate neurones ; Premotor area ; Horseradish peroxidase ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The organization of the cortico-caudate projection neurones in the cerebral cortex was demonstrated by utilizing retrograde axonal transport of horseradish peroxidase (HRP) in the cat. Following injection of HRP into the head portion of the caudate nucleus, cortical labelled cells with HRP could be divided into two groups, consisting of smaller and larger pyramidal neurones. The location of the smaller neurones in the cortex was mainly in layer III, while that of the larger neurones was exclusively in layer V. In the cerebral cortex ipsilateral to the HRP-injected side, labelled cells belonging to the smaller group were distributed mostly in area 6 and occasionally in areas 4 and 5. Labelled cells belonging to the larger group were located exclusively in area 6. In the contralateral cortex, labelled cells were all smaller in size and distributed only in area 6. Referring to recent physiological as well as anatomical data, the smaller, labelled pyramidal cells were considered to be the proper, direct cortico-caudate neurones. The larger, labelled pyramidal cells were regarded as cortico-caudate projection neurones also sending axons to the lower brains tern and/or the spinal cord. The results of the present study indicate the existence of a close relationship between area 6 (premotor area) of the cerebral cortex and the caudate nucleus.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-1041
    Keywords: Key words 5-Fluorouracil ; Hair analysis; adjuvant chemotherapy ; oral administration ; compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract.  Objective: Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and its potential usefulness is discussed as an index of compliance with postoperative adjuvant chemotherapy. Methods: Hair samples obtained from 55 patients, who had received oral 5-FU (total dose 27-41 g) as postoperative adjuvant chemotherapy over a 6-month period, were used for the analysis of 5-FU. The drug was extracted from the hair using ethyl acetate, and its fluorescence derivatization was employed for measurement with HPLC. The detection limit of 5-FU in hair was 0.01 ppm. Results: In 22 out of 55 samples 5-FU content was under the detection limit, whereas in the remaining 33 samples the drug was detected in a range of 0.006-2.125 ng per hair strand; in addition, drug content showed a log-normal distribution. 5-FU was detected in the hair collected from those patients who were possibly compliant with the postoperative oral adjuvant chemotherapy. Conclusion: As many as 40% of the patients analysed were supposed to be much less compliant. Even in the possibly compliant patients, the degree of compliance with the therapy varied according to a log-normal distribution.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 139 (1997), S. 690-691 
    ISSN: 0942-0940
    Keywords: Chondroma ; dura mater ; teratoma ; fat tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...