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  • 1
    ISSN: 1432-0428
    Keywords: Islet amyloid polypeptide ; amylin ; diabetes mellitus ; fasting concentration ; oral glucose tolerance test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fasting plasma islet amyloid polypeptide concentrations and their responses to an oral glucose load were determined in non-diabetic control subjects and patients with abnormal glucose tolerance in relation to the responses of insulin or C-peptide. Plasma islet amyloid polypeptide was measured by radioimmunoassay. In the non-diabetic control subjects, fasting plasma islet amyloid polypeptide was 6.4±0.5 fmol/ml (mean ± SEM) and was about 1/7 less in molar basis than in insulin. The fasting islet amyloid polypeptide level rose in obese patients and fell in patients with Type 1 (insulin-dependent) diabetes mellitus. In non-obese patients with impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetic patients without insulin therapy, the level was equal to that of the control subjects, but a low concentration of islet amyloid polypeptide relative to insulin or C-peptide was observed in the non-obese Type 2 diabetic group. The patterns of plasma islet amyloid polypeptide responses after oral glucose were similar to those of insulin or C-peptide. However, compared to non-obese patients, a hyper-response of islet amyloid polypeptide relative to C-peptide was noted in obese patients who had a hyper-response of insulin relative to C-peptide. This study suggests that basal hypo-secretion of islet amyloid polypeptide relative to insulin exists in non-obese Type 2 diabetes and that circulating islet amyloid polypeptide may act physiologically with insulin to modulate the glucose metabolism.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0165-7992
    Keywords: Edible brown seaweeds ; Heterogenous antimutagenic activity ; Laminaria japonica (Makonbu) ; Undaria pinnatifida (Wakame)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European spine journal 2 (1993), S. 197-202 
    ISSN: 1432-0932
    Keywords: Moelle spinale ; Racines spinales ; Compression médullaire ; Laminectomie ; Vertèbres cervicales ; Spinal cord ; Spinal nerve roots ; Spinal cord compression ; Laminectomy ; Cervical vertebrae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Paralysis of the arm with radicular distribution occurring after posterior decompression of the cervical spinal cord included C5, C6, C7 and C8 roots, in isolation or combined. The most frequent patterns of paralysis were C5 and C6 root involvements of the motor-dominant type. The overall frequency of occurrence in our series was 11% (20 cases of postoperative paralysis in 188 surgical cases), but the frequency varied with the posterior decompression method. The higher frequency of postoperative paralysis was noted in the group in which the surgical procedures selected were considered as enabling the expanded dura to exert its traction power more easily on the extradural portion of the roots. Radiographical analyses showed that C5 roots which satisfied the following two conditions were more prone to sustain postoperative paralysis: first, location at the level of the highly expanded dural tube and, second, lying in the foramina with a higher degree of anterior protrusion of the superior process. In the majority of cases with C5 motor-dominant paralysis, the postoperative cord-root pouch distances of the C5 anterior roots were unchanged or even decreased compared with the preoperative ones, but the extradural portions of the C5 roots were elongated in all cases. These findings support the validity of mechanisms of postoperative paralysis which were deduced from the anatomical investigations.
    Notes: Résumé Une paralysie brachiale de topographie radiculaire, survenant après une décompression postérieure de la moelle spinale, impliquait de manière isolée ou associée les racines C5, C6, C7 et C8. Les formes les plus fréquentes de ces paralysies comportaient l'atteinte des racines C5 et C6 réalisant un tableau neurologique à prédominance motrice. La fréquence globale de cette complication a été de 11% dans notre série (20 cas de paralysie postopératoire sur 188 cas opérés), mais cette fréquence a été variable selon la méthode de décompression postérieure utilisée. La plus grande fréquence des paralysies postopératoires a été notée dans le groupe de patients où des techniques chirurgicales choisies semblaient faciliter davantage la transmission des forces de traction durale à la portion extradurale des racines. Les analyses radiographiques ont montré que les racines C5 qui remplissent les deux conditions suivantes ont davantage tendance à présenter une paralysie postopératoire: 1° par leur localisation au niveau de l'expansion maximale du sac dural et 2° par leur situation dans le foramen qui présente le plus haut degré de protrusion antérieure du processus articulaire supérieur. Dans la majorité des cas présentant une paralysie motrice prédominant en C5, les distances postopératoires entre la moelle et les culs-de-sac radiculaires des racines antérieures C5 étaient inchangées et même diminuées en comparaison des distances préopératoires, mais les portions extradurales des racines C5 étaient allongées dans tous les cas. Ces découvertes renforcent la validité des mécanismes des paralysies postopératoires déduits des recherches anatomiques de la lère partie de ce travail.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über 22 Fälle von “InterSterno-Costo-Clavikulärer Ossifikation” berichtet. Die klinischen und pathologisch-anatomischen Befunde zeigen, daß die abnorme Ossifikation durch tine nichteitrige, chronische Entzündung im Bereiche der Sterno-Costo-Clavikular-Region und des costo-clavikulären Ligamentes hervorgerufen wird. Wir klassifizieren die Röntgenbefunde in 3 Stadien, entsprechend dem Grad der Verknöcherung: lokalisiert, generalisiert und hyperostotisch. In dieser Reihenfolge schreitet auch die Erkrankung fort. Eine betrdchtliche Zahl der Patienten zeigten auch abnorme Röntgenbefunde an der Wirbelsäule oder den Sacroiliacalgelenken. Eine häufige Begleiterscheinung der Erkrankung war auch eine Pustolosis palmaris et plantaris. Die meisten Fälle wurden erfolgreich mit entzündungshemmenden Medikamenten behandelt; bei einigen Patienten wurde eine Besserung der Beschwerden erst nach chirurgischer Entfernung der verknöcherten Masse, einschließlich Clavikula oder 1. Rippe, erzielt.
    Notes: Summary We present 22 cases with inter-sterno-costoclavicular ossification. Clinical and pathological findings show that abnormal ossification observed in this situation is due to non-suppurative chronic inflammation of the soft tissues around the sterno-costo-clavicular region such as the costo-clavicular ligament. We have classified X-ray findings into three stages according to the extent of the ossification; localized, generalized, and hyperostotic, and show that the disease progressed in this sequence. A considerable number of the patients showed abnormal X-ray findings in the spine or the sacro-iliac joint. Frequent association of pustulosis palmaris et plantaris was noted in this disease. Most of the cases were treated effectively with anti-inflammatory drugs, but a few cases required surgical resection of the ossified mass with the clavicle or the first rib in order to relieve the severe pain.
    Type of Medium: Electronic Resource
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