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  • 1
    Electronic Resource
    Electronic Resource
    Intracellular mechanisms of nitric oxide plus hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells (1998)
    Springer
    Inflammation research 47 (1998), S. 428-433 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Protein kinase G — Protein kinase C — Intracellular calcium — Protein kinase A — Tyrosine kinase — Potassium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We investigated signal-transduction in nitric oxide/hydrogen peroxide (NO/H2O2) mediated neutrophil-endothelial adhesion and P-selectin mobilization.¶Materials and Methods: Human endothelial monolayers (HUVEC) were exposed to 0.1 mM H2O2 plus an NO donor, 0.5 mM spermine-NONOate, and second message inhibitors and neutrophil adhesion and P-selectin expression measured.¶Results: Neutrophil adherence induced by NO/H2O2 was blocked by a PKG inhibitor, (KT5823, 0.5 μM), a PKC inhibitor, (Gö6976, 10 nM), a calcium chelator, TMB-8 (0.1 mM) and a K+ channel blocker, glibenclamide, (10 μM), but not by a PKA inhibitor, (H-89, 0.1 μM) or a tyrosine kinase inhibitor, (genistein, 1 μM). P-selectin expression induced by NO/H2O2 was blocked by KT5823 and Gö6976, but not by TMB-8 or glibenclamide.¶Conclusions: These data demonstrate that NO/ H2O2 promotes neutrophil-endothelial adhesion through PKG, PKC, calcium, and K+ channels, but not PKA or tyrosine kinase. Conversely, P-selectin mobilization requires only PKG and PKC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050356
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Pro^1^1^7 to glycine mutation of staphylococcal nuclease simplifies the unfolding-folding kinetics
    Amsterdam : Elsevier
    FEBS Letters 290 (1991), S. 135-138 
    Details
    ISSN: 0014-5793
    Keywords: Circular dichroism, Site-directed mutagenesis ; Folding mechanism ; Proline isomerization ; Staphylococcal nuclease ; Stopped-flow technique
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)81243-2
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Aplasia cutis congenita associated with an immature arteriovenous malformation (1990)
    Springer
    European journal of plastic surgery 13 (1990), S. 268-271 
    Details
    ISSN: 1435-0130
    Keywords: Aplasia cutis congenita ; Arteriovenous malformation ; Scalp reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The first case of congenital defect of the skull and scalp in Japan, probably due to an immature arteriovenous malformation, is presented. In this case, an island of healthy scalp remained intact in the central area of the scalp defect, unlike previously reported cases. The dilated, tortuous scalp vessels apparently disappeared spontaneously only after multiple ligation. Because of slow wound healing, three successive operations were subsequently needed to cover the scalp defect. The cause of the aplasia cutis congenita and the delayed wound healing mechanism was investigated histologically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208330
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  • 4
    Electronic Resource
    Electronic Resource
    Poly(3-hydroxybutyrate) as an endogeneous substrate for H 2 evolution in Rhodovulum sulfidophilum (1997)
    Springer
    Biotechnology letters 19 (1997), S. 1209-1212 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract In the absence of an external substrate, H 2 was evolved in Rhodovulum sulfidophilum under light-anaerobic conditions, along with degradation of poly(3-hydroxybutyrate) (PHB). Cells grown with succinate as a sole carbon source accumulated only a small amount of PHB compared with that in cells grown with a multiple substrate consisting of a mixture of four organic acids. Unlike PHB-containing cells, PHB-deficient cells did not evolve H in the absence of an external substrate. Nitrogenase activity was expressed while no hydrogenase activity was detected during the incubation of PHB-containing cells. These results suggest that intracellular PHB serves as a substrate for the H evolution catalyzed by nitrogenase when an external substrate is lacking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018437921006
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    Paper (German National Licenses)
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