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  • 1
    Electronic Resource
    Electronic Resource
    Effects of exogenous and endogenous histamine on the respiratory system (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 991-996 
    Details
    ISSN: 1432-1440
    Keywords: Histamine ; Obstructive air way disease (OAD) ; Oversensitive bronchial system ; Histamine receptors ; Histamin ; Bronchokonstriktion ; überempfindliches Bronchialsystem ; Histamin-Rezeptoren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es besteht eine statistisch strenge Korrelation zwischen dem Anstieg der Histaminkonzentration im arteriellen Plasma und dem Anstieg der Strömungswiderstände in den Atemwegen bei experimentell verursachter allergischer Atemwegsobstruktion. Das Histamin wird an sensorischen Rezeptoren im Sinne einer Reflexbronchokonstriktion wirksam. Histamin verursacht in geringen Konzentrationen im Bronchialsystem eine unspezifische Empfindlichkeitssteigerung. Diese kann auch durch Allergene in sehr geringer Konzentration hervorgerufen werden. Patienten mit chronisch obstruktiver Bronchitis haben hohe Histamin-Konzentrationen im Sputum. Durch Waschungen der inneren Oberfläche des Bronchialbaums lassen sich hohe Histamin-Konzentrationen in der Spülflüssigkeit nachweisen. Die Gabe gleicher Histamin-Konzentrationen intravenös verursacht Bronchokonstriktion. Es ist anzunehmen, daß Histamin-Rezeptoren nahe der Oberfläche der Bronchialschleimhaut vorhanden sind. Ebenso müssen in der Oberfläche oder auf der Oberfläche der Bronchialschleimhaut Mastzellen vorhanden sein.
    Notes: Summary There is a statistically strong correlation between the increase of the histamine concentration in the arterial plasma and the increase of airway resistance. The histamine causes a reflex bronchoconstriction on the sensory receptors. Histamine in low concentration increases the unspecific reaction in the bronchial system. This can also be achieved using low concentrations of allergen aerosols. Patients with chronic obstructive bronchitis show high concentrations of histamine in the sputum. The bronchoconstrictive potency of this histamine was found to be not always active. Higher concentrations of histamine can be liberated by washing the inner surface of the bronchial tree. Histamine injected in similar concentrations as that measured in the sputum causes bronchoconstriction. There should be high concentrations of histamine receptors as well as mast cells near the surface of the mucosa of the bronchial wall. There are many questions remaining open, which will be discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716960
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  • 2
    Electronic Resource
    Electronic Resource
    Flexible integration of various fieldbus and sensor/actuator bus systems into machine tool control (1997)
    Springer
    Microsystem technologies 3 (1997), S. 191-198 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  This paper deals with the integration of different types of standardised and available fieldbus and sensor/actuator bus systems into control systems and applications. The concept for integration and the first steps of realisation considering the bus systems PROFIBUS, CAN and INTERBUS are presented here. This includes a simple but unified application programming interface (API) on all underlying interfaces including standardised fieldbus systems and other improvements for the adaptation to different fieldbus systems. A main feature of these improvements is that there is no recompilation necessary in case of exchanging field bus systems, making the integration of different fieldbus systems much easier. The remaining work for the system integrator is to modify a few configuration tables which are written in ASCII text and easy to handle. The presented concept is realised using VME bus systems with Motorola CPU board, real time operating system OS-9 and hard- and software modules for the interfaces to PROFIBUS, CAN and INTERBUS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050079
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  • 3
    Electronic Resource
    Electronic Resource
    Sodium ions and water molecules in the structure of poly(dA)·poly(dT) (1995)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 1025-1035 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Analysis of X-ray diffraction data from a polycrystalline and well oriented fiber of the sodium salt of poly(dA)·poly(dT) shows that this B′-DNA corresponds to a right-handed antiparallel tenfold double-helix of pitch 32.4 Å, with C2′-endo furanose rings in both strands. The helix contrasts itself from B-DNA in terms of a very narrow minor groove. Difference electron-density maps have revealed that a continuous spine of water molecules, two per base pair, propagates along this groove with the same symmetry as the DNA and establishes new links between the two strands. In addition to this hydrated DNA helix, the monoclinic unit cell (space group P21) accommodates about 20 sodium ions and 12 water molecules in the vicinity of phosphate groups. These structured guest molecules provide an intricate network of bridges, ranging in size from a single sodium ion to a multiple sodium–water–water–sodium unit, connecting phosphate groups belonging to adjacent DNA helices. The crystallographic R value for this structure is 0.23 for a total of 102 reflections extending out to 3.2 Å resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995001880
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  • 4
    Electronic Resource
    Electronic Resource
    The First Data from the MACHO Experiment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 688 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb43945.x
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  • 5
    Electronic Resource
    Electronic Resource
    Modification of magnetic properties of epitaxial Co/Cu multilayers by 1 MeV C+ irradiation (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 2036-2038 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial [Co/Cu]10 grown on Si (001) has been irradiated by 1 MeV C+ with a dose of 1×1016/cm2. The intrinsic characteristics of epitaxy, such as crystal structure and fourfold magnetic anisotropy, are conserved after ion irradiation. However, the extrinsic magnetic properties are changed such that the coercivity decreases and the squareness of the hysteresis loop is noticeably improved. The intensity of the Cu (200) peak in the x-ray diffraction pattern increases about three times and its half-width decreases after irradiation. It is concluded that the changes of magnetic properties induced by ion irradiation result from the grain growth and the improved crystalline quality. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1384483
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  • 6
    Electronic Resource
    Electronic Resource
    correction: The DNA sequence of human chromosome 21 (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 407 (2000), S. 110-110 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nature 405, 311— 319; 2000. The name of one author, Y. Groner, was inadvertantly omitted from the author list but is included above. He is affiliated with the Department of Molecular Genetics and Human Genome Center, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35024135
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  • 7
    Electronic Resource
    Electronic Resource
    The DNA sequence of human chromosome 21 (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 405 (2000), S. 311-319 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35012518
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  • 8
    Electronic Resource
    Electronic Resource
    Buckwheat flour hypersensitivity: an occupational asthma in a noodle maker (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background There have been very few reports of occupationai allergies caused by inhalation of buckwheat flour. In this paper, we present a case of occupational asthma and rhinitis caused by buckwheat flour inhalation.Methods and results The patient had strong positive responses to grass and ragweed poiiens as well. The bronchoprovocation test showed early asthmatic response to buckwheat flour extracts. Serum specific IgE antibody to buckwheat flour was detected by enzyme-linked immunosorbent assay (ELISA). In order to further identify the allergenic component of the extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were performed. Eight IgE binding components (9–55 kDa) were detected within the buckwheat flour extracts.Conclusion These results suggest that inhalation of buckwheat flour can caused IgE mediated bronchoconstriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb00558.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hypersensitivity pneumonitis induced by Penicillium expansum in a home environment (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An episode of fever, cough, shortness of breath and leucocytosis developed in a 31-year-old atopic housewife from mould exposure in her home environment is evaluated. A chest radiograph revealed diffuse tiny nodular infiltrations in both whole lung fields. Spirometry revealed a severe restrictive type of ventilation impairment. Bronchoalveolar lavage (BAL) showed an increased lymphocyte count with reversed CD4 +/CD8 + ratio and transbronchial lung biopsy showed markedly increased lymphocytic infiltration in alveolar septa. Fungal cultures in the air of her home were positive for Penicillium expansum and other fungi. Double immunodiffusion test with the patient's serum showed two precipitin bands to P. expansum antigens. Her symptoms, abnormal findings of radiograph, and spirometric abnormalities disappeared after 2 months' avoidance. The serum precipitin disappeared after 1 month's avoidance. This study indicates that the patient had hypersensitivity pneumonitis (HP) on exposure to P. expansum in her home environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00251.x
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  • 10
    Electronic Resource
    Electronic Resource
    Heterogeneity of IgE antibody response to reactive dye in sera from four different sensitized workers (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied RAST and RAST inhibition tests to black GR, the most frequent sensitizer among several reactive dyes in our previous study, in order to evaluate the specificity of IgE antibodies to hapten or new antigenic determinants and the crossreactivity between two reactive dyes, black GR and orange 3R, in sera from four different sensitized workers. RAST inhibition studies with black GR-human serum albumin (HSA) conjugate discs demonstrated that black GR-HSA conjugates were the most effective inhibitors. Orange 3R-HSA conjugates, unconjugated forms of black GR and orange 3R were weak inhibitors in two patients and non-inhibitory in one patient, whereas they caused strong dose-dependent inhibitions in one patient. These results suggested that the IgE response to black GR-HSA conjugates might be heterogenous and the cross-reactivity between two reactive dyes differed from one patient to another.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00176.x
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