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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the in vitro binding of D-penicillamine to cholestyramine (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 482-484 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4–8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/1) inhibited this small adsorption by 87%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952651
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  • 2
    Electronic Resource
    Electronic Resource
    Caffeine elimination: A test of liver function (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1124-1128 
    Details
    ISSN: 1432-1440
    Keywords: Liver disease ; Liver function ; Caffeine elimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fasting plasma caffeine concentration and various parameters of caffeine elimination from plasma obtained after a standardized oral dose of 140 mg caffeine have been compared in nine patients with liver cirrhosis, eight patients with non-cirrhotic liver disease and ten healthy volunteers with regard to their ability to discriminate between the different groups. Fasting plasma caffeine concentrations were significantly higher in cirrhotics (11.1±10.5 μmol/l) than in healthy volunteers (1.5±0.8 μmol/l). The respective values measured in patients with non-cirrhotic liver disease (3.1±3.1 μmol/l) did not differ significantly from the controls. Plasma disappearance rate and clearance of caffeine were significantly decreased in cirrhotics (0.11±0.02 h−1; 1.0±0.3 ml/min per kg) and in patients with non-cirrhotic liver disease (0.18±0.04 h−1; 2.2±0.7 ml/min per kg) as compared to healthy volunteers (0.23±0.04 h−1; 3.1±0.9 ml/min per kg). Plasma caffeine concentration determined 12 h after administration of the test dosage discriminated best between patients with cirrhosis (5.4±1.6 μmol/l), patients with noncirrhotic liver disease (2.0±1.4 μmol/l) and healthy volunteers (0.8±0.2 μmol/l). These results, the safety of the test compound and the simplicity of a single caffeine determination in plasma 12 h after a standardized dose of caffeine make this test attractive for evaluation of liver function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02291094
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  • 3
    Electronic Resource
    Electronic Resource
    Regulation of atrial natriuretic factor release in man: Effect of water immersion (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 666-667 
    Details
    ISSN: 1432-1440
    Keywords: Atrial natriuretic factor ; Water immersion ; Human subjects ; Plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726920
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  • 4
    Electronic Resource
    Electronic Resource
    Prophylaxis of first variceal hemorrhage in patients with liver cirrhosis (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 1267-1275 
    Details
    ISSN: 1432-1440
    Keywords: First variceal hemorrhage ; Prophylaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prophylaxis of bleeding from esophageal varices is a very tempting concept at first glance, especially under the assumption of a high mortality associated with first variceal hemorrhage. Up to now four different measures have been tried for prophylaxis: portacaval shunt operation, devascularization procedures, sclerotherapy, and drugs. With the exception of portacaval shunts, ongoing controlled trials show a weak trend toward reduction of variceal bleeding and prolongation of survival in selected patients with compensated cirrhosis and large varices. However, prophylaxis of first variceal bleeding must still be regarded as experimental and should be restricted to controlled clinical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01785707
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  • 5
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 647-648 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477843
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  • 6
    Electronic Resource
    Electronic Resource
    Soybean lipoxygenase inhibition: Studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 449-451 
    Details
    ISSN: 1432-1041
    Keywords: lipoxygenase inhibition ; antiinflammatory drugs ; N-acetyl-aminosalicylic acid ; 5-aminosalicylic acid ; sulphapyridine ; soybean ; therapeutic actions ; ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Soybean lipoxygenase inhibition has been proposed as an in vitro biochemical model for the antiinflammatory action of certain drugs used in the treatment of ulcerative colitis. In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0×10−8M, IC50 250 µM). Sulphapyridine, the other major metabolite of sulphasalazine, which has been demonstrated to be inactive in the treatment of ulcerative colitis, did not inhibit the lipoxygenase activity. The findings further support the hypothesis that only the therapeutically active compounds are soybean lipoxygenase inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542139
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 279-283 
    Details
    ISSN: 1432-1041
    Keywords: ketoconazole ; terbinafine ; microsomal metabolism ; caffeine ; male volunteers ; pharmacokinetics ; drug interaction ; cytochrome P-450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of single oral doses of ketoconazole 400 mg and terbinafine 500 mg on the hepatic microsomal system have been investigated in 8 healthy male volunteers. Microsomal activity caffeine was assessed by following the metabolism of 3 mg/kg bodyweight i.v. administered 1 h after the drug. The inhibitory effect of terbinafine was more pronounced than that of ketoconazole: clearance was decreased from 1.34 ml·kg−1·min−1 in controls to 1.06 and 1.21 ml·kg−1·min−1, respectively, and the corresponding half-life was increased from 5.8 h in controls to 7.6 and 6.7 h, respectively. The apparent volume of distribution remained unchanged. The serum levels of the antimycotics were within the therapeutic range in each subject. Although all three substances are metabolised by microsomes, the kinetic parameters (Cmax, half-life, elimination constant) of the antimycotics were poorly if at all correlated with the elimination of caffeine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679784
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetics of sulphasalazine and sulphapyridine after rectal and oral administration to patients with ulcerative colitis (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 275-277 
    Details
    ISSN: 1432-1041
    Keywords: sulphapyridine ; sulphasalazine ; pharmacokinetics ; rectal administration ; oral administration ; plasma levels ; ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Rectal administration of sulphasalazine to patients with ulcerative colitis has recently been shown to have similar therapeutic activity but fewer side effects than oral treatment. The present study is a comparison of the pharmacokinetics of sulphasalazine (SASP) and its metabolite sulphapyridine (SP) after rectal and oral administration of SASP to 6 patients with ulcerative colitis. The areas under the concentration-time curves (AUC) and the maximum concentrations (Cmax) of SASP and SP were significantly lower after rectal than oral administration of SASP (p〈0.05). These findings support the view that the lower frequency of side effects after rectal administration of SASP may result from the lower plasma levels of SASP and SP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630300
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  • 9
    Electronic Resource
    Electronic Resource
    Tauroursodeoxycholic acid inhibits the cytosolic Ca^+^+ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 171 (1990), S. 1115-1121 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(90)90800-3
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  • 10
    Electronic Resource
    Electronic Resource
    Biliary lipid composition in early childhood
    Amsterdam : Elsevier
    Clinica Chimica Acta 64 (1975), S. 241-246 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(75)90350-2
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