ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Somatostatin, secretin, and glucagon have been shown to inhibit gastric acid secretionin vivo and thus have been postulated to act directly on the parietal cell. To test the hypothesis that these peptides directly influence the acid secretory cells, we studied the effect of the three gastrointestinal hormones using aminopyrine uptake as an index of acid production. The parietal cells were stimulated to increase aminopyrine uptake by submaximal concentrations of histamine (10−6 mol/l), methacholine (10−6 mol/l), and pentagastrin (10−6 mol/l), but in no concentrations did these gastrointestinal hormones affect any of the secretagogues' response. Our data suggest that gastrointestinal peptides do not modulate acid secretion at the parietal cell level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01971476
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