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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 35 (1963), S. 153-154 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 580-582 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 44 (1993), S. 63-67 
    ISSN: 1432-1041
    Keywords: Mexiletine ; Debrisoquine hydroxylation phenotype ; pharmacokinetic ; variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine-type may have on mexiletine pharmacokinetics was considered in this study. The pharmacokinetics and urinary excretion of mexiletine (250 mg administered intravenously) were investigated in 5 rapid extensive metabolisers (EM), 5 slow EM and 5 poor metabolisers (PM) of debrisoquine, under conditions of controlled urinary pH. Mexiletine disposition kinetics was found to be altered in PM individuals. These subjects showed higher total area under the curve (AUC), (15.7 versus 8.16 μg · h · ml−1) prolonged elimination half-lives (in serum and urine) (serum: 18.5 versus 11.6 h, urine: 19.2 versus 11.7 h) and lower total clearance values compared with EM (216 versus 450 ml · min−1). In this respect, slow EM individuals generally presented intermediate values of those pharmacokinetic parameters. A higher incidence of adverse-effects was also observed among slow EM and PM subjects. It is concluded that genetic differences in mexiletine oxidation of the debrisoquine-type have an influence on its observed pharmacokinetic variability. The clinical consequences are discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 39 (1984), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case is reported of probable subdural injection of bupivacaine during attempted extradural analgesia for an operative obstetric procedure.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 74 (1967), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Advances in contraception 1 (1985), S. 103-108 
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On peut envisager la mise au point de nouveaux contraceptifs administrês par voie orale et qui exercent leurs effets en se concentrant dans la glaire cervico-vaginale. Six femmes volontaires bien portantes ont reçu dud-propranolol par voie orale, à des doses de 80 mg. Des prélèvements de plasma et de glaire cervico-vaginale ont été recueillis avant l'ingestion du médicament et à 6 reprises jusqu'à 24 heures après. On a constaté que led-propranolol se concentrait dans la glaire cervico-vaginale. On n'a observé aucune modification de la pression artérielle, de la fréquence cardiaque ou du débit expiratoire maximum.
    Abstract: Resumen Es posible desarrollar nuevos contraceptivos que puedan ser administrados por boca y vayan a producir efecto después de concentrarse en el moco cervico-vaginal. Se administró por bocad-propanolol en dosis de 80 mg a seis voluntarias sanas. Se obtuvieron muestras de plasma sanguíneo y de moco cervico-vaginal antes y en seis ocasiones hasta 24 horas después de la ingestión de la droga. Eld-propanolol fué concentrado en el moco cervico-vaginal. No se observaron cambios en la presión sanguínea, en el pulso o en el pico de expiración forzada.
    Notes: Abstract It may be possible to develop new contraceptives that can be administered by mouth and will exert their effects after concentration in cervico-vaginal mucus.d-Propanolol was administered in 80 mg doses by mouth to six healthy female volunteers. Samples of blood plasma and cervico-vaginal mucus were obtained before and on six occasions up to 24 hours after drug ingestion.d-Propranolol was concentrated in cervico-vaginal mucus. No changes in blood pressure, pulse, or forced expiratory peak flow (FEPF) were observed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of assisted reproduction and genetics 11 (1994), S. 495-499 
    ISSN: 1573-7330
    Keywords: pentoxifylline ; sperm motility ; spermocytogram ; hypoosmotic swelling test ; acrosome reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose Pentoxifylline was tested in three raising concentrations (0.7 mM/l, 1.5 mM/l, 3.6 mM/l) on human sperm cells in vitro. Methods On 143 samples, we examined drug effect on motile sperm concentration, grade of their motility, acrosome reaction and membrane status. Results Obtained results show improvement in motile sperm concentration, as well as in the grade of progression in the majority of samples. Conclusions Spermatozoa membranes as well as occurrence of the acrosomal reaction were not affected by penoxifylline.
    Type of Medium: Electronic Resource
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