ISSN:
1420-9071
Keywords:
Key words. Calcium channels; molecular cloning; gene expression; antihypertensives; antiepileptics.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000180050460
Permalink