ISSN:
0138-4988
Keywords:
Life Sciences
;
Life Sciences (general)
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The number of stability of steady states of minimal structured models are determined theoretically. Regulation of two “bottle-necks” of cell metabilism by extracellular or intracellular or intracellular intermediates is suggested. The mechanisms of this regulation include substrate and product feed-forward inhibition as well as feedback product control. The most complex system behaviour is obtained in models with feed-forward intermediate inhibition. In particular these models exhibit multistability and two limit cycles.The maximum number of steady states decreases from five to four when the extracellular intermediate is changed by the intracellular one. The number of non-zero steady states is changed from four to two.The relevant features of phase-portrait appear to be independent of the choice of reaction rates. Therefore our results are suitable for a large group of the third order modles. The possibility to verify the theoretical predictions experimentally is also discussed.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/abio.370100510
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