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  • 1
    Electronic Resource
    Electronic Resource
    A pharmacological and clinical comparison of prednisolone and betamethasone in rheumatoid arthritis (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: prednisolone ; betamethasone ; rheumatoid arthritis ; adrenal suppression ; chronic dosage ; anti-inflammatory activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Two oral corticosteroids, prednisolone (8 mg/day) and betamethasone (1 mg/day) have been compared in terms of efficacy and adrenal suppressive activity when used in chronic oral dosage in rheumatoid arthritis. 2. 20 patients were entered to a single blind crossover study receiving each drug for a two-week period. Clinical and laboratory assessments were performed. 3. At this dosage there was no significant difference between any of the clinical parameters assessed for either drug though patient preference was 13 for prednisolone and 7 for betamethasone. 4. At this dosage adrenal suppression was not equivalent, being significantly more marked with betamethasone. 5. The results suggest that prednisolone is the drug of choice for chronic dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613613
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dose dependent pharmacokinetics of prednisolone (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 213-219 
    Details
    ISSN: 1432-1041
    Keywords: Prednisolone pharmacokinetics ; intravenous dosing ; plasma clearance ; half-life ; volume of distribution ; plasma protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg·kg−1 and 0.3 mg·kg−1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609864
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A lack of pharmacokinetic interaction between ranitidine and piroxicam (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 583-586 
    Details
    ISSN: 1432-1041
    Keywords: ranitidine ; piroxicam ; interaction ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of piroxicam (40 mg) on the pharmacokinetics of ranitidine (150 mg) and of ranitidine (150 mg bid) on the pharmacokinetics of piroxicam (20 mg) were assessed in two 2-way crossover studies in two groups of 18 healthy male subjects. In the first study there were no statistically significant differences between the pharmacokinetic variables for ranitidine in the presence or absence of piroxicam. The mean maximum plasma concentration (Cmax) was 467 ng·ml−1 for ranitidine alone and 466 ng·ml−1 in the presence of piroxicam; mean area under the plasma concentration vs time curve (AUC) was 2460 h·ng ml−1 and 2551 h·ng ml−1 respectively; and the mean terminal half-life (t 1/2) was 3.6 h and 3.8 h respectively. In the second study there were no statistically significant differences between the pharmacokinetic variables for piroxicam in the presence or absence of ranitidine. The mean Cmax was 2.1 μ·ml−1 in the presence of placebo and 2.0 μg·ml−1 in the presence of ranitidine respectively; mean AUC was 133 h·μg ml−1 and 137 h·μg ml−1 respectively, and the mean t 1/2 was 53.6 h and 54.5 h respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316100
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  • 4
    Electronic Resource
    Electronic Resource
    Serum biochemistry in relation to the action of azathioprine in rheumatoid arthritis (1983)
    Springer
    Inflammation research 13 (1983), S. 373-379 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a long-term study we have been comparing biochemical changes in the blood of patients with classical or definite rheumatoid arthritis (RA) when groups of patients are treated for the first time with specific anti-rheumatoid drugs for a six-month period. One such group was treated for 26 weeks with azathioprine. Biochemical and clinical assessments were made at each of 10 clinic visits during the treatment period. Side-effects prevented six patients completing the study. Clinical improvement in the remaining patients was accompained by a reduction in acute phase proteins, increases in total serum sulphydryl and serum histidine, but little or no change in immunological variables. Comparison of correlation matrices constructed between clinical and laboratory variables for azathioprine and drugs previously tested suggests that azathioprine more effective than a control group on aspirin alone and in some ways comparable withd-penicillamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971492
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of drugs on serum histidine levels in rheumatoid arthritis (1983)
    Springer
    Rheumatology international 3 (1983), S. 145-149 
    Details
    ISSN: 1437-160X
    Keywords: Anti-rheumatoid ; Drugs ; Histidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of d-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541592
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Salivary of blood specimen for evaluation of drug concentration in rheumatoid arthritis (1985)
    Springer
    Clinical rheumatology 4 (1985), S. 220-220 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032298
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    Paper (German National Licenses)
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