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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 8 (1952), S. 345-347 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto Gli Autori hanno compiuto l'analisi cromatografica degli idrolisati di nuclei, cromosomi isolati ed istone di cellule ematiche normali e patologiche. Vennero esaminati: eritrociti di pollo; leucociti (normali e da ascesso) di cavallo; leucociti umani normali; linfociti di leucemia linfatica e leucociti di leucemia mieloide. I vari componenti cellulari ottenuti mediante il Waring blender e successive centrifugazioni differenziali; vennero idrolizzati con HCL. Con gli idrolisati vennero allestiti cromatogrammi bidimensionali in due sistemi di solventi; butanolo acetico e fenolo, fenolo e collidinalutidina. In tutti i cromatogrammi bidimensionali dei due sistemi di solventi si sono potuti mettere in evidenza 14 amino acidi (acido aspartico, acido glutammico, serina, glicina, treonina, alanina, prolina, valina, tirosina, leucina, fenil-alanina, arginina, lisina e istidina).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 4 (1950), S. 621-629 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. A comparison has been made between the chromatic threads isolated from erythrocyte nuclei and chromosomes of diploid metaphase plates of several vertebrates. A close resemblance in morphological and structural features was found. It is therefore concluded that isolated filaments are true resting stage chromosomes. 2. Measurements showed all species to possess rather similar ranges of length of isolated chromosomes, but different species differ characteristically in the frequencies of the different length groups. The mitotic chromosomes, measured on published drawings, correspond closely in length with the isolated chromosomes within a species and show the same interspecific differences.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 964-965 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A Perkin-Elmer, model 21, double-beam spectrometer with sodium chloride and calcium fluoride optics has been used. With slit-widths narrower than those used by Blout and Lenormant4 and with suitable adjustments, we were able to improve the resolution. The deuterium solutions were prepared in the ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0584
    Keywords: Hairy cell leukemia ; Immunohistochemistry ; Interferon ; Monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow biopsies from 7 patients afflicted with hairy cell leukemia were studied with a panel of monoclonal antibodies at different intervals during alpha recombinant interferon therapy. Monoclonal antibodies Dako-LC and F 8.11.13 were used because they are highly reactive with hairy cells, and 82 H 3 and LeuM 1 were also utilized to identify respectively the residual hemopoietic and myeloid tissue. All antibodies are reactive on sections of formalin-fixed, paraffinembedded biopsy material. Before therapy a uniform hairy cell infiltrate was present and very little tissue was visible even after immunohistochemical staining. During therapy, identification of hairy cells in routine biopsies was difficult, since they were mixed with normal cells and the bone marrow was generally hypoplastic. Immunohistochemical stains seem to allow better identification of hairy cells and a more precise estimate of the degree of repopulation by normal bone marrow cells. It was evident, especially after immunocytochemical analysis, that interferon drastically reduced the extent of the infiltrate and allowed recovery of normal hemopoiesis, but did not produce complete remissions.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndromes ; Bone marrow biopsy ; FAB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration (“diffuse,” “cluster,” and “large”) were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was “diffuse” in 18, “cluster” in 48, and “large” in 40 cases. RAEB-t patients accounted for about half of the “large” cases, and none had a “diffuse” pattern (p〈0.01). Nineteen patients showed extensive BM fibrosis; most of them were characterized by “cluster” blastic infiltration and megakaryocyte hyperplasia. Leukemic transformation occurred in 67% of “large” cases (p〈0.001) and in none of the “cluster” cases with severe BM fibrosis (p〈0.01); however, survival was equally poor in these two groups because of early leukemic transformation (large cases) and BM failure (cluster cases). The FAB classification did not significantly correlate with prognosis. Patients with “cluster” BM infiltration and severe fibrosis can be regarded as a true separate MDS subset characterized by unique clinicopathological and prognostic features. Because of the subacute clinical behavior of most cases, and the poor performance status of many elderly patients, there is still controversy as to the best therapeutic approach in MDS. Histological analysis allowed two groups of MDS patients to be identified, both characterized by poor life expectancy, who could benefit from early aggressive chemotherapy.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Bone marrow biopsy ; Hodgkin's disease ; Non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone marrow biopsy (BMB) is a routine investigation in the diagnosis and staging of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL), and there is evidence supporting its prognostic importance in some histological varieties. The histological characteristics of BMB in 433 NHL and 155 HD patients were reviewed for clinicopathological correlations; 36 of these cases were also studied by means of immunohistochemistry. BM infiltrates were discovered in 171 NHL patients. In 36 cases, the diagnosis of NHL was directly established by BMB; a discordance between lymph node and BM histology was observed in 38 of the other 135 cases. BM-positive centroblastic and immunoblastic NHL were significantly associated with larger infiltrates, BM fibrosis, and megakaryocytic hyperplasia. Leukemization at diagnosis was more frequent in low-malignancy NHL. No correlation was found between histology and prognosis, although immunohistochemistry revealed a B-cell phenotype in all but two cases. BMB was positive in 18 of the 155 HD patients and directly diagnostic in two; Reed-Sternberg and Hodgkin cells were CD-30 positive and surrounded by T-cell infiltration. The concordance between BM and lymph node histology was fairly satisfactory, although the relationships between BM infiltration and other histological parameters may reflect peculiar interactions with BM microenvironmental factors. The usefulness of BMB in the diagnosis of malignant lymphomas has been demonstrated, and further progress can be expected from the availability of reliable immunohistochemical markers of clonality reacting on paraffin-embedded BM sections.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 7 (1951), S. 138-140 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto Sono stati isolati i cromosomi da globuli bianchi umani normali e leucemici. Le osservazioni compiute su materiale colorato a fresco e con la reazione di Feulgen hanno permesso di constatare: 1° La possibilità di riconoscere cromosomi isolati anche nella specie umana; 2° Un diverso comportamento dei cromosomi normali rispetto ai leucemici anche nella fase di riposo cellulare concordamente a quanto osservato sulle mitosi.
    Type of Medium: Electronic Resource
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