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  • 1
    Electronic Resource
    Electronic Resource
    Multicentre comparison of cephacetrile and ampicillin in the treatment of urinary tract infections (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 331-336 
    Details
    ISSN: 1432-1041
    Keywords: Cephacetrile ; ampicillin ; urinary tract infections ; renal function ; multicentre trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy and tolerability of cephacetrile and ampicillin in the treatment of urinary tract infections have been compared in a between patient, single blind, multicentre controlled trial. 68 in-patients were treated with cephacetrile or ampicillin in doses of 1 to 4 g/day, according to their creatinine clearances, for an average of 10 days. The two drugs had similar therapeutic effects, i.e. they produced significant decreases in leucocyturia (p〈0.001) and urinary culture colony counts (p〈0.001). No side effects were observed. The direct Coombs' test remained negative in all patients, even in those with advanced renal failure. To determined whether renal function was affected by treatment, creatinine clearance, and cylindruria, erythrocyturia and proteinuria were assessed in 24 h urine samples, before and after drug administration. None of these parameters were altered, except for a decrease in cylindruria (p〈0.05) after cephacetrile. It was concluded that cephacetrile was as active as ampicillin in the treatment of urinary tract infections and that there was no evidence of nephrotoxicity in the doses employed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558201
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  • 2
    Electronic Resource
    Electronic Resource
    Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 319-322 
    Details
    ISSN: 1432-1041
    Keywords: tientilic acid ; hydrochlorothiazide ; hypertension ; diuretics ; hyperuricemia ; hypouricemic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To compare the clinical and metabolic effects of a new diuretic uricosuric agent, tienilic acid, with those of hydrochlorothiazide, a multicentre double-blind trial was performed in 56 hypertensive patients. Twenty — eight patients were randomly assigned to take tienilic acid and 28 to take hydrochlorothiazide. The diuretic and anti-hypertensive actions of the two compounds were similar. No significant differences were observed between tienilic acid and hydrochlorothiazide in their effects on urinary and serum electrolytes, hepatic and renal function tests, and fasting lipids. The patients who received tienilic acid showed a significant fall in serum uric acid, mediated by the uricosuric effect. The availability of an agent combining diuretic, anti-hypertensive and hypouricemic effects offers promise in the treatment of arterial hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00605628
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetic study of the new sulfamethopyrazine-trimethoprim combination (kelfiprim) in renal insufficiency (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 345-348 
    Details
    ISSN: 1432-1041
    Keywords: kelfiprim ; trimethoprim combination ; sulfamethopyrazine combination ; pharmacokinetics ; renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The combination of trimethoprim (TMP) and sulfamethopyrazine (SMP) has been successfully used to treat chronic urinary tract infections. Since parenchymal involvement associated with renal insufficiency of varying degree is not infrequent in these patients, it was considered important to study the pharmacokinetics of TMP and SMP in a fixed dose combination. Four groups of patients were studied: 1) 4 patients with endogenous creatinine clearance (CLcR) between 80 and 40 ml/min; 2) 3 patients with CLcR between 40 and 10 ml/min; 3) 3 patients on chronic peritoneal dialysis (CAPD); and 4) 3 patients on haemodialysis. A single oral dose of 250 mg TMP and 200 mg SMP was given to each patient. Multiple samples were collected over 9 days and the following pharmacokinetic parameters were calculated: total area under the plasma level curve, slow disposition rate constant β and the corresponding t1/2β, plasma clearance and the apparent volume of distribution. The results show that the two moieties of the TMP-SMP combination behaved differently in uraemic patients as fas as elimination rate was concerned. TMP was eliminated more slowly both in patients with diminished renal function and in those subjected to haemo- or peritoneal dialysis. The reduction in the rate of elimination of TMP was significantly correlated with the degree of renal impairment. The elimination of SMP, however, was not significantly affected by the reduced renal function; indeed a tendency to increase was noted, at least in dialyzed patients. However, as in patients with mild renal insufficiency (CLcR〉40 ml/min) no substantial change in plasma clearance rate need be expected, the TMP-SMP combination could be given to them in the same dose schedule as in people with normal renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542173
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  • 4
    Electronic Resource
    Electronic Resource
    Double recurrence of FSGS after two renal transplants with complete regression after plasmapheresis and ACE inhibitors (2000)
    Springer
    Transplant international 13 (2000), S. 166-168 
    Details
    ISSN: 1432-2277
    Keywords: Key words Recurrence of focal segmental glomerular sclerosis ; Kidney transplantation ; Plasmapheresis ; ACE-inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient who had undergone a first cadaveric donor kidney transplantation for idiopathic focal segmental glomerular sclerosis (FSGS), had an immediate recurrence of a biopsy-proven FSGS that eventually led to graft failure within 5 years from transplantation. The patient underwent a second cadaveric transplantation 10 months later. An immediate recurrence of a biopsy-proven FSGS occurred that was treated with two protracted cycles of plasmapheresis of seven months each, with the addition of an ACE inhibitor from the beginning. A complete and stable remission of FSGS was observed, which continues after more than 6 years from the end of plasmapheresis. The recurrence of FSGS after a second transplantation has a poor prognosis, but prolonged plasmapheresis treatment, by removing circulating factors altering glomerular permselectivity, and the addition of ACE inhibitors, through their potential interference with TGF-β, might be synergistic in obtaining permanent remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050316
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  • 5
    Electronic Resource
    Electronic Resource
    Worse outcome in younger adult renal graft recipients with HCV infection. An 8-year prospective study (2000)
    Springer
    Transplant international 13 (2000), S. S90 
    Details
    ISSN: 1432-2277
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050283
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of increased arterial resistance index on long-term outcome of well-functioning kidney grafts (2000)
    Springer
    Transplant international 13 (2000), S. S84 
    Details
    ISSN: 1432-2277
    Keywords: Key words Color Doppler ultrasonography ; Donor nephrectomy ; Renal transplantation ; Renal resistance index ; Renal volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An abnormal vascular status is present in the transplanted kidney. To define whether vascular factors might influence kidney function of the graft, the renal volume, blood flow and vascular resistance of a group of healthy subjects were compared with those of a group of well functioning renal transplants by color Doppler ultrasonography. Sixty healthy subjects and 75 well functioning cadaver renal transplant recipients were compared by color Doppler ultrasonography. Subsequently, 15 couples of donors and recipients of a living related renal graft were compared to observe the differences between the two organs of the same subject in a different environment. The variables studied were: the diameters and the volume of the kindey, renal blood flow and renal resistance index (RI). The group of cadaver renal transplant patients showed higher mean blood pressure (P = 0.009), higher serum creatinine levels (P = 0.0001) and lower endogenous creatinine clearance (P 〈 0.0001) than healthy controls. The length (P 〈 0.00001) and volume (P 〈 0.001) of the kidneys of cadaver transplanted patients were significantly greater than those of healthy subjects, while the length and volume of the living donors kidneys were identical to those of the recipients. RI, measured on renal vessels, showed lower values in healthy subjects and in kidney donors than in transplantated patients (P 〈 0.00001). Well functioning transplanted kidneys showed increased renal arterial RI. This non-immunologic factor did not appear to be detrimental with renal function in time, at least until 50 months after successful grafting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050282
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