ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The author studied the mechanism of Diphacyl action upon the cortical activity of adrenal glands in white male rats. Diphacyl enhances the activity of the adrenal cortex (reduces the ascorbic acid content therein, provokes eosinopenia in the peripheral blood system) only in intact animals, and not in hypophysectomized rats. Experiments with the administration of Diphacyl is connected with its central action. Anticholinesterase substances reduce the action of Diphacyl on the hypophysis-adrenal system. Consequently the stimulating effect of Diphacyl upon the adrenal function is associated with the action of this preparation in the area of the central cholinergic synapses. At the expense of this effect, Diphacyl possibly facilitates the secretion of ACTH of the hypophysis, stimulating the discharge of 17-hydroxycorticosterones into the blood.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00783511
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