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  • 1
    Electronic Resource
    Electronic Resource
    Akuttherapie anaphylaktoider Reaktionen (1994)
    Springer
    Der Anaesthesist 43 (1994), S. 211-222 
    Details
    ISSN: 1432-055X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050050
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  • 2
    Electronic Resource
    Electronic Resource
    Penicillin-Toleranzinduktion zur Therapie der Neurolues bei Penicillinallergie (1999)
    Springer
    Der Hautarzt 50 (1999), S. 194-197 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Penicillinallergie ; Neurolues ; Toleranzinduktion ; Key words Penicillin Allergy ; Neurolues ; Induction of Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Pharmacologically or immunologically induced hypersensitivity to penicillin is frequent. Immunological, i.e., allergic, hypersensitivity reactions are among the most important side effects and can lead to severe and life-threatening reactions. All types of allergic reactions have been described secondary to penicillin therapy. Immediate type hypersensitivity reactions, the symptoms of which range from urticaria and angioedema to respiratory and cardiovascular symptoms, and finally to life threatening full anaphylactic shock are particularly dangerous. This case-report demonstrates that in a patient allergic to penicillin, in whom there is a vital indication to administer this compound, the drug can be given safely after tolerance induction.
    Notes: Zusammenfassung Pharmakologisch oder immunologisch bedingte Unverträglichkeitsreaktionen gegenüber Penicillinen sind häufig. Immunologische, also allergische Überempfindlichkeitsreaktionen gehören zu den wichtigsten Nebenwirkungen und können zu schweren und z.T. lebensbedrohlichen Reaktionen führen. Prinzipiell sind durch Verabreichung von Penicillinen alle Formen allergischer Reaktionen möglich. Besonders gefürchtet sind Soforttypreaktionen, deren Symptome von Urtikaria und Quincke-Ödem über leichte Atemnot und Herz-Kreislauf-Reaktionen bis hin zum lebensbedrohlichen anaphylaktischen Schock reichen. Mit dem hier dargestellten Fallbericht soll gezeigt werden, daß bei wichtiger Behandlungsindikation die Anwendung von Penicillin auch bei Patienten mit Penicillinallergie nach Toleranzinduktion möglich ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050888
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  • 3
    Electronic Resource
    Electronic Resource
    Ethylenediamine contact dermatitis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 25 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01867.x
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  • 4
    Electronic Resource
    Electronic Resource
    Sensitization to thimerosal and previous vaccination (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 32 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb00764.x
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  • 5
    Electronic Resource
    Electronic Resource
    Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Hyposensitization with bee venom leads to full protection in most, but not all patients with IgE-mediated systemic reactions to bee stings.Objective: To determine the relationship of clinical reactivity to the release of mediators and to changes of antibody concentrations in the peripheral circulation at a bee sting challenge test.Methods: Blood was sampled before (0 min) and at 15, 60 and 180 min after a sting challenge from 19 patients on hyposensitization. Of these, six still reacted and 13 were protected. Histamine, mast cell tryptase, bee venom-specific IgE and IgG in the serum, and histamine release from peripheral blood leucocytes (PBL) upon exposure to bee venom were determined.Results: Tryptase above the detection level was found only at 15 (60)min in 4/6 (1/6) patients who reacted. After the sting challenge there was a significant increase of the histamine levels in patients who reacted at 15 min (P 〈 0.05) and in patients who did react at 60 and 180 min (P 〈 0.01). The total histamine content of PBL was significantly decreased after 15 and 60 min in patients who reacted (P 〈 0.01) and in those that did not (P 〈 0.05). Bee venom-induced histamine release was significantly reduced in patients reacting and those that did not at 15 min (P / 0.05), and was significantly decreased in reactors also at 60 and 180 min (P 〈 0.05/0.01). Specific IgG antibodies showed a minor decrease (P 〈 0.05) after the sting challenge in both groups, whereas specific IgE did not change significantly.Conclusion: These results indicate that bee venom anaphylaxis is associated with the release of mediators from both mast cells as well as basophils. Successful hyposensitization does not induce a state of immunological non-reactivity, but rather alters the magnitude and the pattern of mediator release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb00007.x
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  • 6
    Electronic Resource
    Electronic Resource
    Emergency treatment of allergic reactions to Hymenoptera stings (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Allergic reactions to Hymenoptera stings are frequently observed all over Europe. Rarely they may induce long-standing morbidity or even be fatal. Several investigations have shown that the emergency treatment given to these patients is often inadequate. Cutaneous symptoms respond well to antihistamines and also to adrenaline. Adrenaline is the mainstay for outside hospital treatment of more severe reactions involving the respiratory tract (bronchial asthma, laryngeal oedema) and the cardiovascular system (anaphylactic shock). Inhaled adrenaline is especially useful in respiratory symptoms, while parenteral application of adrenaline is prefered for shock treatment. All patients with severe respiratory or cardiovascular reactions must be hospitalized, treated under intensive care conditions and observed for at least 24 hr. Emergency medications including adrenaline for inhalation or for self-injection must be given to all patients with a history of systemic allergic reactions to hymenoptera stings. These patients must also get instructions for safety measures to avoid further stings. They should be referred to an allergist in order to evaluate the indication for venom immunotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01659.x
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  • 7
    Electronic Resource
    Electronic Resource
    Some alterations of the leucoeyte β2-adrenoceptor/cAMP-system in patients with seasonal allergic rhinoconjunctivitis are related to disease activity (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Disturbances of β2-adrenoceptors are discussed as a pathogenic factor in atopic diseases.Methods In this study tbe expression and function of β2-adrenoceptors on peripheral blood leucocytes (PBL) of seven atopic patients with seasonal rhinoconjunctivitis and their seven healthy controls was evaluated in relation to disease activity. Earlier reported data during pollen. season were now compared with data obtained from the same subjects after their allergic symptoms had subsided.Results The variables that had indicated a β2-adrenoceptor subsensitivity in tbe patients during pollen season returned to control values, i.e. the reduced β2-adrenoceptor affinity, the reduced β2-adrenoceptor sensitivity, the reduced increase of intracellular cyclic adenosine monophosphate (cAMP) content upon stimulation with isoproterenol, and the reduced cAMP plasma concentration (values no longer significantly different from those of controls). However, the variable that had suggested an increase in activity of the cAMP degrading enzyme phosphodiesterase (PDE), i.e. the reduced basal intracellular cAMP content of the patients, remained reduced after the pollen season (4.9 ± 1.1 pmol/lO6’cells in patients vs 8.2 ± 0.9pmol/106 cells in controls: P 〈 0.05). There were no significant differences in β2-adrenoceptor density between patients and controls at both investigations.Conclusions Atopic seasonal rhinoconjunctivitis is associated with various alterations in the PBL β2-adrenoceptor/cAMP system that depend on disease activity. The reversible β2-adrenoceptor subsensitivity is likely to be a consequence of the disease, whereas the irreversibly decreased basal intracellular cAMP content, suggested an elevated PDE activity, might be a basic trait of atopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.1997.5108777.x
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  • 8
    Electronic Resource
    Electronic Resource
    Preventive effect of an E. coli-filtrate (Colibiogen®) in polymorphous light eruption (1989)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 121 (1989), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During the administration of Colibiogen®, a commercially available E. coli-filtrate, there was a significant (P〈0.01) increase of the test dose of UVA necessary to elicit skin lesions in nine patients with polymorphous light eruptions. Control tests performed in the same manner without the drug indicate that this was due to treatment. Colibiogen® appears to be of value in the treatment of polymorphous light eruption (PLE).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb01803.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hypersensitivity to non-steroidal anti-inflammatory drugs and chronic urticaria cured by treatment of Blastocystis hominis infection (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.473212.x
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  • 10
    Electronic Resource
    Electronic Resource
    Ultraviolet-A radiation induces adhesion molecule expression on human dermal microvascular endothelial cells (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ultraviolet radiation is capable of inducing numerous skin reactions. Considerable amounts of UVA radiation penetrate the epidermis and reach the microvascular endothelium of the papillary dermis. In order to investigate putative direct effects of UV radiation on endothelial cells, we studied adhesion molecule expression by immunostaining procedures and FACS analysis, following irradiation of normal human skin and cultured human dermal endothelial cells. Enhanced immunostaining for ICAM-1 and E-selectin was detected in biopsies taken after in vivo UVA and UVB irradiation, compared with non-irradiated control skin. On cultured human dermal endothelial cells, however, ICAM-1 and E-selectin were inducible by UVA but not UVB. The induction was dose-dependent, peaking at 20 J/cm2 for both adhesion molecules, and time-dependent, peaking after 6 and 24 h for E-selectin and ICAM-1, respectively. Expression of VCAM-1 and PECAM/EndoCAM/CD31 was unaffected by any UV-radiation modality. The functional integrity of irradiated cells was monitored by an exclusion assay of the fluorescent dye 7-AAD, and by staining for the cytoskeletal proteins actin and vimentin.Our results demonstrate that dermal microvascular endothelial cells are a critical and direct target of UVA, and suggest they may play a pivotal role in UV-induced inflammatory skin conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08516.x
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