ISSN:
1365-2761
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Abstract. The livers of Atlantic tomcod, Microgadus tomcod (Walbaum), from the Hudson and Pawcatuck Rivers were evaluated histologically and described using paraffin and plastic sections. Fatty infiltration, basophilic foci, areas of cellular alteration and hepatocellular carcinoma were widespread in Hudson River samples. In fact, no truly normal tissues were found. Pawcatuck samples had variable levels of lipid and a low prevalence of other alterations. Evaluation of the histological evidence suggests that hepatocellular carcinoma in Hudson River tomcod results from multiple DNA lesions and that areas of cellular alteration give rise to the larger, more invasive form of hepatocellular carcinoma. Glutaraldehyde and OsO4 fixed livers were used to determine differences in cell types and lipid levels. Pawcatuck samples possessed hepatocytes and dark cells forming the parenchymal tissue, whereas Hudson samples lacked dark cells. Hepatic lipid levels were significantly higher in Hudson River fish than in Pawcatuck fish, 36·3 and 11·0% respectively. The elevated hepatic lipid levels in Hudson River tomcod may represent a metabolic response to detoxification.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2761.1989.tb00282.x
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