ISSN:
1432-2072
Keywords:
Serotonin
;
Hallucinogens
;
LSD
;
p-Chloroamphetamine (PCA)
;
p-Chlorophenylalanine (PCPA)
;
Drug-induced stimulus control
;
Phosphoinositide hydrolysis
;
5-HT2A
;
5-HT2C
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The present study was designed to determine the effects ofp-chlorophenylalanine (PCPA) andp-chloroamphetamine (PCA) administration on (1) the levels of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rat brain, (2) the sensitivity of LSD-trained rats to the stimulus effects of LSD, and (3) the maximal levels of 5-HT2A and 5-HT2C receptor mediated phosphoinositide (PI) hydrolysis in rat brain. PCA and PCPA both produced a significant depletion of whole brain 5-HT and 5-HIAA concentrations. The depletion of serotonin with PCPA, but not PCA, resulted in supersensitivity of LSD-trained subjects to the stimulus effects of LSD. Neither PCPA nor PCA treatment altered the maximal level of 5-HT2A receptor-mediated PI hydrolysis. However, PCPA, but not PCA, treatment resulted in a significant upregulation (46%,P〈0.05) of the maximal level of 5-HT2C receptor mediated PI hydrolysis. These data suggest that upregulation of the 5-HT2C receptor mediates the supersensitivity to LSD discriminative stimulus which follows the depletion of central nervous system serotonin by PCPA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02246076
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