ISSN:
1572-901X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The reactions of N,N,N′,N′-tetramethylthiuram disulfide (tmtds) with gold(III) complexes of the [Au(L)X3] type [L = N-methylimidazole (N-Melm), 2-methylbenzoxazole (2-MeBO) and 2,5-dimethylbenzoxazole (2,5-diMeBO), X = Cl, Br or I] are reported, and yielded two main types of product - [Au(Me2dtc)X2] (A) and [Au(Me2dtc)2]X (B) (Me2dtc = N,N-dimethyldithiocarbamato anion). The ratio of the product yields (B/A) depends upon the nature of the ligand (L) and halogen (X). The ratio B/A for the reaction: [Au(L)Cl3] + tmtds = A + B, increases in the sequence N-MeIm 〈 2- MeBO 〈 2,5-diMeBO, which correlates well with the level of cytotoxic activity exhibited by the [Au(L)Cl3] complexes. A and B were characterized by their i.r., u.v-vis. and 1-n.m.r. spectra. The magnetic measurements were also recorded. The data support a squareplanar geometry for gold(III) complexes with the Me2dtc ligand bonded in a bidentate fashion; a conjecture has been verified crystallographically for [Au(Me2NCS2)2]-Br·2H2O. The X-ray analysis confirmed that the complex is composed of ionic units: [Au(Me2dtc)2] + and Br− and H2O molecules. The Au—S distances are markedly similar, falling in the 2.343(4)–2.350(3) ∘A range.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00136550
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