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  • 1
    Electronic Resource
    Electronic Resource
    Prenatal development of coronary arteries in the rat: morphologic patterns (1999)
    Springer
    Anatomy and embryology 200 (1999), S. 533-540 
    Details
    ISSN: 1432-0568
    Keywords: Key words Coronary vasculogenesis ; Angiogenesis ; Coronary artery ; Development ; Rat ; Embryonic heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this work was to address spatiotemporal and morphologic patterns of coronary artery development in rats, based on immunohistochemical and ultrastructural studies of hearts at different stages of prenatal development. Griffonia simplicifolia I lectin and α-smooth muscle antibody were used to demonstrate endothelial cells and/or their precursors and smooth muscle cells, respectively. Ultrastructural examination was performed on ED14–16 hearts to study the morphology of the developing coronary arteries in different regions of the truncus arteriosus and adjacent myocardium. On ED14 endothelial-like cells present within the mesenchyme surrounding the outflow tract penetrated the aortic wall and the truncoconal proximal myocardium. On ED15 these penetrating cells formed vascular clusters, which were the first signs of presumptive vascular channels. Development of the coronary artery proceeded by coalescence of discontinous vascular clusters, formation of the lumen (vascular channels) and establishing a connection of the proximal part with the aorta. The second layer of cells around vascular channels (embryonic media) consisted of mesenchymal cells that were attracted to the immature vessel and were first seen on ED15. At this time no lumenized connection of the coronary artery with the aorta has been seen. After the lumenized connection of the coronary artery with the aorta had been established perivascular cells of the media started to differentiate into vascular smooth muscle, as was shown by α-smooth muscle actin-staining. Further development and differentiation of the media and adventitia proceeded distally (towards the apex).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290050301
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Some extracellular matrix elements as markers of ‘capillary tunnels’ in hypertrophied rat heart (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 964-968 
    Details
    ISSN: 1420-9071
    Keywords: Heart hypertrophy ; spontaneously hypertensive rats ; tunnel capillaries ; fibronectin ; laminin ; immunohistochemical staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We studied the distribution of the extracellular matrix proteins fibronectin (FN) and laminin (LM) in the hypertrophied hearts of spontaneously hypertensive rats (SHR), using an immunofluorescence method with specific antibodies. The immunohistochemical reaction was positive in the cytoplasm of some hypertrophied cardiomyocytes. The results showed that FN and LM can be used as markers for tunnels, i.e. intracardiocytic invaginations of the sarcolemma. The tunnels observed contained capillaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929893
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tunnel capillaries in hypertrophied myocardium of rats with aorto-caval fistula (1993)
    Springer
    Basic research in cardiology 88 (1993), S. 120-129 
    Details
    ISSN: 1435-1803
    Keywords: Volume overload heart hypertrophy ; fibronectin ; laminin ; tunnel capillaries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male inbred rats (Wag) with aorto-caval fistula were used as a model of volume-overloaded heart hypertrophy. Hearts were taken after 1, 2, and 6 months postoperatively for immunohistochemical, histological and ultrastructural investigations. Immunohistochemical staining with some anti-extracellular matrix antibodies and ultrastructural findings allowed us to recognize intracardiocytic tunnels which were intracellular invaginations of plasmalemma surrounded by basement membrane. Inside the tunnels endothelial cells forming well-developed capillaries were entrapped. Tunnel capillary formation is discussed as an adaptive response to increased cardiac work due to volume overload.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00798260
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    Paper (German National Licenses)
    Fulltext
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