ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Protein adsorption onto metal oxide surfaces is an essential aspect of the cascade ofbiological reactions taking place at all interfaces between implanted materials and thebiological environment. The types and amounts of adsorbed proteins mediate subsequentadhesion, proliferation and differentiation of cells. Protein adsorption to surfaces of metaloxides and their kinetics are important in the formation and growth of seashells, one of thetoughest natural ceramics, in modern bio-analytical devices as well as in bone and teethimplant technology. This paper describes results obtained in a feasibility study of how to usemetal-oxide particles to obtain biosensors with a high turnover. The most important featuresof proteins are outlined describing them as purpose-built "polymers" from amino acids withspecific conformations. Some key aspects of Metaloxide (MeO) surfaces in water and theinfluence of electrostatic and hydrophobic interaction on protein adsorption are reported.Results concerning the interaction between different proteins and MeO surfaces in water arediscussed in detail. Examples of purely electrostatic interactions of proteins with MeOsurfaces as well as the influence of hydrophobic interaction are elucidated. An outlook of theimplications of the new insights on natural and synthetic materials will be given concerningbio-compatibility, bio-mineralization and self assembly of materials
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.45.741.pdf
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