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  • 1
    Electronic Resource
    Electronic Resource
    Human proinsulin standards (1984)
    Springer
    Diabetologia 27 (1984), S. 414-415 
    Details
    ISSN: 1432-0428
    Keywords: Human proinsulin ; radioimmunoassay ; standards
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two new batches of pancreatic human proinsulin have been compared with biosynthetic human proinsulin. Standards of these three proinsulin preparations were made on the basis of quantitative amino-acid analyses and compared in two proinsulin radioimmunoassays with a proinsulin standard prepared 14 years ago. The curves of the new standards were superimposable. However, they differed considerably from the curve of the old standard which proved to be only one-third of the strength of the new standards, thereby leading to a threefold over-estimation of proinsulin concentrations when the old standard is used. We conclude that the new standards should replace previously used standards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304860
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical pharmacokinetics of vindesine (1979)
    Springer
    Cancer chemotherapy and pharmacology 2 (1979), S. 243-246 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of vindesine were investigated in five patients with advanced cancer who were receiving the drug. Following a rapid IV bolus dose, vindesine kinetics were described by a triphasic serum decay curve compatible with a three-compartment open mammillary model. Serum half-lives were 2 min, 50 min, and 24 h for the fast, middle, and slow phases, respectively. The volume of the central compartment approximated the plasma volume in all patients studied. Distribution occurred quickly into a superficial tissue compartment in fairly rapid equilibrium with the plasma compartment, and also into a deep tissue compartment with slower redistribution to the central compartment. The large apparent volume of distribution and long elimination half-live suggest extensive tissue sequestration or delayed excretion of the drug in man. The slightly increased serum half-life of vindesine compared with published results for vinblastine may account for the greater degree and longer duration of marrow suppression seen clinically with vindesine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257188
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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