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  • 1
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 920-924 
    ISSN: 1432-1440
    Keywords: Angiomyolipoma ; Bourneville's disease ; Tuberous sclerosis ; Renal complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cases with renal angiomyolipoma in Bourneville's disease are reported. In two patients advanced renal insufficiency developed, one being treated by chronic intermittent hemodialysis. In the third patient rupture of angiomyolipoma with severe retroperitoneal bleeding occurred. In one patient, tumorous enlargement initially was diagnosed only in the right kidney and preceded angiomyolipoma of the left kidney for several years. In this patient nephrectomy was performed because malignancy was assumed before diagnosis of Bourneville's disease was established. Occasionally, histology may suggest sarcomatous changes. However, the absence of distant metastasis and the overall long survival of patients with renal angiomyolipoma in Bourneville's disease underline the benign character of the tumor. Treatment should be conservative because surgical intervention with loss of kidney parenchyma may enhance progression to end-stage renal failure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 285-289 
    ISSN: 1432-1440
    Keywords: Secretin ; Somatostatin ; Hemorrhage ; Peptic ulcer ; Stress lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a randomized trial the efficiency of synthetic secretin (0,25 clinical units/kg bw/h; 15 patients) was compared with that of synthetic somatostatin (250 µg/h, 15 patients) in treatment of severe acute non arterial bleeding from peptic ulcers or stress lesions in the upper digestive tract. In all patients the presence of hemorrhage at beginning of the therapy was established by endoscopic examination. Both test preparations were given as continuous infusions over 48 h and had identical effects on the hemorrhage: in 12 patients (80%) out of each group bleeding stopped during the infusion of secretin or somatostatin, 6 patients (20%) had to be operated on for persistant bleeding or severe recurrence.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Many therapeutic drugs exert their effects by interaction with well defined molecular targets. Increasing knowledge in molecular biology allows identification of more and more molecular key compounds and in consequence a molecular approach to disease and therapy. As binding of drugs to their target compounds is a key event, binding assays with an appropriate target molecule are useful means for primary screening of novel substances. We have investigated the potential of thin film interference spectroscopy (RIFS) as a label free detection method for pharmaceutical screening in a binding inhibition assay. To meet the throughput requirements in pharmaceutical screening a parallel detection system based on imaging spectroscopy was constructed. Thrombin/thrombin inhibitor interaction was investigated as a model system. The thin film transducer was covalently modified with a thrombin inhibitor. Specific binding of thrombin and binding inhibition by inhibitor compounds could be observed. A test cycle of less than 10 min could be reached. The parallel setup allows the simultaneous detection of 96 binding curves and can reach a throughput of more than 106 samples per year.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cell Biology International Reports 14 (1990), S. 234 
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 11 (1987), S. 635-641 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'échographie opératoire a été pratiquée chez 21 malades porteurs au total de 22 tumeurs endocrines du pancréas: 17 accusaient un hyperinsulinisme organique, 4 un Zollinger-Ellison, 1 un insulinome associé à un PPome. Quinze des insulinomes se manifestaient par une lésion visible et palpable. Chez 2 malades la lésion ne fut pas découverte lors de l'intervention initiale et c'est seulement à la seconde opération que la tumeur fut détectée grâce à l'échographie chez l'un des deux, l'autre devent être opéré ultérieurement. Le PPome ignoré fut identifié par l'exploration. Chez 4 malades présentant un syndrome de Zollinger-Ellison, un gastrinome fut localisé dans le pancréas et 2 dans la paroi duodénale par la palpation. Chez un patient le gastrinome ne fut découvert ni par l'exploration chirurgicale ni par la sonographie. Dans l'un des cas identifiés, la tumeur fut décelée par l'échographie. Chez un malade la tumeur était trop petite pour être accessible à l'exploration échographique. Deux des cas présentaient des métastases hépatiques qui ne pouvaient être découvertes que par l'échographie hépatique. Il résulte de cette expérience que l'échographie opératoire doit être une exploration systématique lors des interventions pour apudomes.
    Abstract: Resumen Se practicó ultrasonografía operatoria (USIO) en 21 pacientes con 22 tumores endocrinos del páncreas. Diecisiete pacientes exhibían hiperinsulinismo orgánico; 4 presentaban sindrome de Zollinger-Ellison. Un paciente con insulinoma tenía un PPoma como segundo tumor. Quince de los insulinomas investigados por USIO eran visibles y palpables. En 2 pacientes no se halló tumor durante la operación inicial. En la reoperación se detectó un tumor por USIO solamente; está planeada la reoperación en el otro paciente. El PPoma fue un hallazgo incidental durante la USIO. En los pacientes con el síndrome de Zollinger-Ellison, un gastrinoma fue localizado en el páncreas y 2 en la pared duodenal mediante palpación. En un paciente no se encontró gastrinoma, ni por exploración quirúrgica ni por USIO. En uno de los casos positivos el tumor fue demostrable por USIO; en el otro paciente era demasiado pequeno para ser delineado. Dos de los casos tenían metastasis hepáticas que pudieron ser demostradas por USIO solamente. De nuestra experiencia podemos concluír que la USIO debe ser realizada rutinariamente en el curso de operaciones para APUDomas pancreáticos.
    Notes: Abstract Intraoperative ultrasound (IOUS) was performed in 21 patients with 22 endocrine tumors of the pancreas. Seventeen patients suffered from an organic hyperinsulinism, 4 had Zollinger-EUison syndrome. One patient with an insulinoma had a pancreatic-polypeptide-producing adenoma (PPoma) as a second tumor. Fifteen of the insulinomas investigated by IOUS were visible and palpable. In 2 patients no tumor was found during initial operation. At reoperation 1 tumor was detected by IOUS only, the reoperation in the other patient is planned. The PPoma was an incidental finding during IOUS. In 4 patients with Zollinger-Ellison Syndrome, 1 gastrinoma was localized in the pancreas and 2 in the duodenal wall by palpation. In 1 patient we found no gastrinoma by either surgical exploration or by IOUS. In 1 of the positive cases the tumor was demonstrable by IOUS. In the other patient it was too small for imaging. Two of these patients had liver metastases, which could be demonstrated by IOUS only. We conclude that IOUS should be performed routinely in operations for pancreatic APUDomas.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 15 (1991), S. 671-671 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 18 (1994), S. 486-487 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 22 (1998), S. 651-658 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Between 1987 and 1996 a total of 25 patients with proved Zollinger-Ellison syndrome (ZES) have been treated in our department. If preoperative imaging studies did not show diffuse metastatic disease, patients were scheduled for operation with a standardized surgical approach including thorough exploration and intraoperative ultrasonography (IOUS) of the pancreas and a longitudinal duodenotomy, with separate palpation of the anterior and posterior walls. Postoperatively, patients were followed up by physical examination, fasting gastrin levels, and the secretin stimulation test. Altogether 10 patients had duodenal wall gastrinoma, 14 patients pancreatic gastrinoma, and the tumor was not found in 1 patient. Only 15 tumors (60%) (2 duodenal wall and 13 pancreatic gastrinomas) could be visualized preoperatively. Intraoperatively, 24 of 25 primary gastrinomas were localized. The mean size of duodenal wall gastrinomas (9.6 mm) was significantly smaller than that of pancreatic gastrinomas (28.7 mm) ( p 〈 0.05). At the time of surgical exploration, five duodenal and seven pancreatic gastrinomas had metastasized. The incidence of lymph node metastases was similar for both tumor sites, whereas patients with pancreatic gastrinomas more frequently had liver metastases. The presence of liver metastases was the most important determinant for survival. Four patients (40%) with duodenal and seven with pancreatic (50%) gastrinomas (mean follow-up 5.2 years) were biochemically cured by operation. Of the remaining patients, eight are still alive with recurrent disease. Our results suggest that preoperative localization of gastrinomas often fails despite all modern imaging methods. Therefore a standardized surgical exploration of the pancreas including IOUS and a duodenal exploration should be performed to achieve optimal results. Preoperative diagnostic imaging tests should include computed tomography, ultrasonography, and somatostatin receptor scintigraphy to exclude diffuse metastases. In contrast to liver metastases, lymph node metastases do not have a significant influence on survival.
    Type of Medium: Electronic Resource
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