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  • 1
    Electronic Resource
    Electronic Resource
    Diet, cholesterol gallstones, and composition of the bile (1970)
    Springer
    Digestive diseases and sciences 15 (1970), S. 251-260 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions Studies on bile composition with respect to diet, quantity, and composition have been carried out. The composition of Ttube bile has been studied in a group of patients having cholecystectomy for cholelithiasis, and a group of patients having cholecystectomy for other reasons. Our studies suggest that the formation of cholesterol gallstones is related to two factors: (1) An increase in biliary cholesterol concentration when caloric and daily protein intake increases and (2) an increased intake of calories irrespective of diet composition. The in-vitro conditions for precipitation and solubilization of biliary cholesterol are now rather well established. In addition, the changes in biliary cholesterol, bile salts, and phospholipid concentration may be studied under defined experimental conditions. Our studies suggest that the bile of patients with cholelithiasis has a composition from time to time which is favorable for the formation of gallstones. The variations in bile composition appear to be dependent upon the diet: the greater the caloric intake, the more frequently will bile have a composition which favors cholesterol precipitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233456
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  • 2
    Electronic Resource
    Electronic Resource
    Magnetic field penetration and H-T phase diagram of YBaCuO solgel superconductors by susceptibility and microwave absorption data
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 235-240 (1994), S. 1833-1834 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(94)92138-5
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  • 3
    Electronic Resource
    Electronic Resource
    Willingness to Pay for Periodontal Therapy: Development and Testing of an Instrument (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of public health dentistry 59 (1999), S. 0 
    Details
    ISSN: 1752-7325
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective: The objective of this study was to develop and test the feasibility and validity of a willingness to pay (WTP) tool in a dental setting. Methods: A questionnaire measured individuals' preferences among alternative treatments for periodontal disease and the maximum they would be willing to pay for their treatment of choice in terms of dental insurance premiums. The questionnaire provides detailed information, in probabilistic terms, of the risks and benefits of treatment choices for moderate to advanced adult periodontitis. It was pilot tested on 23 periodontal patients and 18 dental school faculty and staff. Results: The majority (92.6%) felt the questionnaire was an accurate representation of treatments and outcomes, establishing face and content validity. In terms of construct validity, four hypotheses were tested: (1) manipulation of the outcomes of the preferred treatment led to a predictable shift in preferences for 38 subjects (92.7%); (2) although periodontal patients were not more likely to choose periodontal surgery than nonpatients (P=.14), those with a history of surgery were more likely to choose surgery again (P=.06); (3) WTP was positively related to income level (P=.05); and (4) subjects were willing to pay more for coverage for themselves than for others. Periodontal surgery was the preferred treatment for moderate to advanced periodontal disease, and was more strongly preferred than other choices (i.e., a higher WTP) for all income groups. The intraclass correlation coefficient for treatment preferences was 0.95 (P〈.001) and the kappa for WTP was 0.78 (P〈.001). Conclusion: This pilot study supports some of the criteria concerning validity of the WTP questionnaire to measure preferences for alternative periodontal therapies. Further testing on larger samples is required to confirm these results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-7325.1999.tb03234.x
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  • 4
    Electronic Resource
    Electronic Resource
    A Note on the Influence of Rail Defects on the Risk Associated with Shipping Hazardous Materials by Rail (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 11 (1991), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Existing approaches to routing hazardous material shipments by rail recognize that track condition is an important influence, but have not included it in the risk assessment and routing models. This note explores the influence of track condition based on predictions of internal defects in the rail. The method developed predicts the expected frequency of accidents and subsequent consequences in terms of the expected number of fatalities accounting for one aspect of track condition—internal defects. It is intended to indicate the magnitude and impact of track condition. The formulation integrates models of consequences and the risk of a hazardous spill found in the literature with the frequency of accidents as a function of the number of defects. The number of defects may be based on observations or predicted as a function of the cumulative traffic. The models are used to calculate the expected number of fatalities per year for a particular route. Application of the methodology to a hypothetical route shows that the risk associated with the transportation of hazardous material shipments varies significantly with the expected number of defects in the track. Therefore, risk not only varies from route to route but over time for any section of track as the condition deteriorates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1991.tb00609.x
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  • 5
    Electronic Resource
    Electronic Resource
    Electron spin resonance spectra of di- and trimethylaminium radicals (1972)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 2857-2859 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100664a012
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  • 6
    Electronic Resource
    Electronic Resource
    Class II major histocompatibility complex typing across the ethnic barrier in pemphigoid gestationis. A study in Mexicans (1999)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 38 (1999), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Pemphigoid gestationis (PG), also called herpes gestationis, is a rare autoimmune disease of pregnancy or puerperium (estimated 1 out of 50,000 pregnancies among Caucasians). A previous series has demonstrated an association of PG with human leukocyte antigen (HLA)-DR3 or HLA-DR4 haplotypes. While these haplotypes are most commonly found in individuals of European ancestry, they have also been found in African–American patients affected with PG. PG has rarely been reported in other ethnic groups, and the HLA association in non-Europeans has not been examined. Methods We have characterized eight patients of Mexican ancestry who have PG by clinical, histologic, and immunofluorescence criteria. Class I and class II major histocompatibility complex (MHC) antigens were studied by standard microlymphocytotoxicity assays. Class II MHC antigens were further studied by polymerase chain reaction (PCR) amplification of HLA-DRB1, DQA, and DQB genes and allele-specific oligonucleotide hybridization. For comparison purposes, we used results obtained from a group of 100 ethnically matched healthy individuals. Results We found that all eight patients had the HLA-DR3/DR4 phenotype; all HLA-DR3 haplotypes were HLA-DRB1*0301, DQA1*0501, and DQB1*0201, whereas half of the HLA-DR4 haplotypes were from the DRB1*0401 subtype and the other half were DRB1*0407. Conclusions These results suggest that, in Mexicans, the genetic susceptibility for the development of PG is strongly influenced by the genetic admixture of Caucasian origin, and the role of class II MHC antigens in the pathophysiology of this disease is confirmed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1999.00524.x
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  • 7
    Electronic Resource
    Electronic Resource
    Evidence-based dermatologic out-patient treatment (1998)
    Oxford, UK : Blackwell Science, Ltd
    International journal of dermatology 37 (1998), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the evidence base for routine therapeutic decisions in dermatologic out-patients.Design A retrospective review of a random sample of primary therapy and literature.Setting University hospital, dermatologic out-patient clinic in CopenhagenMaterial A random sample of the case notes from 115 out-patients.Method The evidence base of therapy prescribed when the diagnosis was ascertained was studied in literature searches in MEDLINE® and EMBASE®. Evidence was structured into primary evidence consisting of randomized controlled trials, and secondary evidence consisting of follow-up studies or the application of trial results between diseases with pathogenic or clinical similarities, e.g. atopic and seborrheic dermatitis.Results Randomized controlled trials could be found describing 38% (95% confidence interval: 30–47) of all treatments. Secondary evidence was found for 33%24–41, while no evidence was found for 23%16–31 of the given treatments.Conclusions Approximately three-quarters of dermatologic out-patient therapy is based on scientific evidence ranging from randomized controlled trials to logical deduction from analogous clinical situations. The proportion of evidence-based medicine in dermatologic therapy therefore appears to be comparable with that of internal medicine and may thus be above expectations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1998.00470.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of vasopressin on water and NaCl transport across the in vitro perfused medullary thick ascending limb of Henle's loop of mouse, rat, and rabbit kidneys (1980)
    Springer
    Pflügers Archiv 383 (1980), S. 215-221 
    Details
    ISSN: 1432-2013
    Keywords: Vasopressin ; Water permeability ; Cl transport ; Transepithelial potential difference ; Adenylate cyclase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Direct tubular effects of arginine vasopressin (AVP) on water and NaCl transport across the medullary thick ascending limb of Henle (MAL) were examined by the in vitro perfusion of isolated nephron fragments of mice, rats, and rabbits. Osmotic water permeability of the MAL of mice and rats was low and remained unchanged with 2 mU/ml AVP added to the bath. A dose-dependent increase in transepithelial electrical potential difference (PD) with AVP was observed in the mouse MAL when the ambient medium was isotonic. A similar result was also obtained when 2×10−4 mol/l dibutyryl adenosine 3′,5′-cyclic-monophosphate was added to the bath. In this preparation, AVP also caused an increase in the unidirectional Cl efflux from 323±45 to 398±61 pmoles·mm−1 ·min−1 (n=6,P〈0.05). In contrast, under similar condition, we could not demonstrate any effect of AVP on PD, Cl efflux, or net Na flux in the rat MAL and on PD and Cl efflux in the rabbit MAL. Both PD and Cl efflux in the rat MAL were unaffected by AVP when the perfusate was made hypotonic. However, when the ambient medium was made hypertonic by adding NaCl and urea, a significant increase in PD was observed. In addition, we confirmed that AVP stimulated adenylate cyclase activity in the MAL as well as in the collecting tubule of mice and rats. We conclude that AVP stimulates Cl transport across the MAL of mice and rats by activating adenylate cyclase-cyclic AMP system. However, this effect of AVP may quantitatively vary among species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587521
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  • 9
    Book
    Book
    2nd Conference on Applications of Simulation : 1968, New York, N.Y. (1968)
    Los Alamitos, CA u.a. :IEEE Computer Society Press,
    Details
    Title: 2nd Conference on Applications of Simulation : 1968, New York, N.Y.
    Contributer: SHARE , ACM , IEEE , SCi
    Publisher: Los Alamitos, CA u.a. :IEEE Computer Society Press,
    Year of publication: 1968
    Pages: 368 S.
    Type of Medium: Book
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    ZIB Catalog
    Zuse Institute Berlin get availability status
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