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  • 1
    Electronic Resource
    Electronic Resource
    Molecular Analysis of Primitive Hematopoietic Cell Proliferation Control Mechanisms (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 628 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb17260.x
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  • 2
    Electronic Resource
    Electronic Resource
    Weight gain during adjuvant chemotherapy for breast cancer (1985)
    Springer
    Breast cancer research and treatment 5 (1985), S. 195-200 
    Details
    ISSN: 1573-7217
    Keywords: adjuvant chemotherapy ; breast cancer ; weight gain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Weight gain during adjuvant chemotherapy has been reported by several authors. Because increased body weight at diagnosis is associated with an increased risk of disease recurrence, we have assessed the prevalence of weight gain in a series of patients receiving adjuvant treatment, as well as the association of weight gain with type of treatment and risk of recurrence. We first assembled an inception cohort of 237 patients who had all undergone pretreatment evaluation and treatment at one institution, and had already been followed for at least 12 months. Body weight at the start and completion of treatment was recorded, as was type of treatment and status at last followup. Ninety-six percent of patients gained weight during treatment and none lost weight (mean increase 4.3 kg). Weight gain was strongly associated with treatment, and was least in patients receiving single agent chemotherapy, greatest in patients treated with ovarian ablation and prednisone, and intermediate in those receiving combination chemotherapy. There was no association between weight gain and disease recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805994
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  • 3
    Electronic Resource
    Electronic Resource
    Allografting for indolent lymphoid neoplasms (2000)
    Springer
    Annals of oncology 11 (2000), S. 59-61 
    Details
    ISSN: 1569-8041
    Keywords: allogeneic bone marrow transplantation ; indolent lymphoid neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Allogeneic bone marrow transplantation (BMT) has beenused in patients with low-grade lymphoma (LGL) and chronic lymphocyticleukemia (CLL) with the goal of achieving long-term disease-free survival. Patients and methods:Twenty-nine patients with these diagnoses(LGL = 19, CLL = 10) received allogeneic BMT between September 1995 andJanuary 1999. Median age was 42 (range 20–52) years. Twenty-three oftwenty-nine patients (79%) were Ann Arbor or Rai stage IV at the timeof transplant; twenty-four (83%) had never achieved complete remission(CR). Donor source was HLA-matched sibling (20), unrelated (8) and syngeneic(1). Results:Seventeen patients are currently alive, a median of 29months (range 1–85) post-BMT with a median KPS of 90%.Twenty-three of twenty-seven evaluable patients (85%) achieved CRpost-BMT. Six patients had refractory/recurrent disease. Death occurredrelated to transplant complications in eight patients and underlying diseasein four. Overall and event-free survival for the whole group is 51% and44%, respectively. Conclusions:Allogeneic BMT for young patients with advanced stageLGL or CLL is a feasible strategy that can result in achievement of long-termdisease-free survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008379605137
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  • 4
    Electronic Resource
    Electronic Resource
    Quality of life assessments and levels of decision making: differentiating objectives (1993)
    Springer
    Quality of life research 2 (1993), S. 297-303 
    Details
    ISSN: 1573-2649
    Keywords: Decision making ; preferences ; health profiles ; utility measurement ; quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this paper is to examine uses of quality of life (QOL) measurements at different levels of decision making within the health care system, ranging from the micro (clinical) level, through the meso (agency, institutional or regional) level to the macro and meta (governmental) levels. We use individualized, group and population-based QOL and preference assessments as illustrative examples of ways in which QOL information and decision making level interact. We conclude that the meso and macro levels pose particularly challenging problems, and suggest that, if the primary emphasis is placed on applications of QOL assessments at the micro (clinical) level of decision making, a research agenda that is much too limited may be adopted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434801
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  • 5
    Electronic Resource
    Electronic Resource
    Opinion polling and decision making: a critical appraisal of quality of life assessment (1994)
    Springer
    Quality of life research 3 (1994), S. 155-162 
    Details
    ISSN: 1573-2649
    Keywords: Decision making ; opinion polling ; quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between quality of life (QOL) assessments and decision making, in relation to the delivery of health services, is subjected to critical appraisal. Three levels of decision making in the health care system are taken into account in the analysis. Criticisms of opinion polling provide the basis for the appraisal. Examples of criticisms considered are: Might the use of QOL information be manipulative? Could the interviews or questionnaires used to obtain QOL data influence personal opinions? Are the methods used sometimes defective and/or superficial? Will QOL information always be used in decision making in ways that are ascertainable and justifiable? It is concluded that the time has come for the main focus of critical appraisal in QOL research to shift, from an emphasis on evaluation of the quality of methods used for assessments of QOL, toward an emphasis on the practical usefulness of QOL data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435258
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  • 6
    Electronic Resource
    Electronic Resource
    Is there a role for preference assessments in research on quality of life in oncology? (1992)
    Springer
    Quality of life research 1 (1992), S. 31-40 
    Details
    ISSN: 1573-2649
    Keywords: Clinical trials ; decision making ; patient preferences ; quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of ways to evaluate interventions that may have an impact on quality of life is a rapidly=developing area of research in clinical oncology, especially within the context of randomized controlled trials. We propose a role for assessments of preferences in such evaluations, including preference studies designed to assess attitudes toward the clinical acceptability of interventions, and preference trials designed to assess choice behaviour in relation to interventions. We suggest that such preference assessments represent a specific case of a more general issue: the need to develop an ‘ethics of evidence’, that is, standards for the creation, assessment and communication of evidence. We then outline a framework within which an ‘ethics of evidence’ might be developed, and suggest that the framework also may provide a useful model for the processes involved in the transfer of research results into clinical practice. As an illustration, we consider the problem of decision making in circumstances where the choice of therapy depends primarily on the patient's own preferences, as, for example, in the choice of mastectomy or breast-conserving treatment in early-stage breast cancer. The long-term goal is to develop criteria which might be used to foster shared rational decision making in such circumstances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435433
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of the mechanical properties of PZT 65/35 using acoustic techniques (1978)
    Springer
    Acta mechanica 30 (1978), S. 293-298 
    Details
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01175909
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  • 8
    Electronic Resource
    Electronic Resource
    A dynamic investigation of fiber-reinforced viscoelastic materials (1974)
    Springer
    Experimental mechanics 14 (1974), S. 304-310 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In recent years, several mathematical models have been proposed to describe the quasi-static response of fiber-reinforced materials, consisting of continuous, elastic fibers embedded in a linear viscoelastic matrix. By assuming that geometric dispersion (dispersion resulting from the internal geometry of the material) is small in comparison to viscoelastic dispersion (dispersion resulting from the viscoelastic nature of the material), these proposed constitutive equations can be extended from a quasi-static regime to a dynamic regime. Here, we examine how the extension to the dynamic regime may be accomplished, compare the results with a theoretical model that includes geometric dispersion, and use the results of an experimental program to evaluate the models. In general, the quasi-static constitutive equations predict phase velocities that are larger than that predicted by the model which contains geometric dispersion and attenuation coefficients that are lower; and, the experimental results agree with the theoretical predictions, provided the fibers were spread more or less uniformly over the cross section.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02324952
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