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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 37 (1989), S. 313-316 
    ISSN: 1432-1041
    Keywords: diprafenone ; pharmacokinetics ; bioavailability ; first-pass metabolism ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the antiarrhythmic drug diprafenone have been investigated in 6 healthy volunteers following single intravenous (50 mg) and oral doses (50 and 150 mg). Diprafenone was mainly eliminated by metabolism in the liver. Following i.v. infusion of 50 mg diprafenone, the terminal half-life of elimination was 1.50 h, the volume of distribution at steady-state was 1.23 l·kg−1, and the free fraction in plasma was 1.68%. Mean total plasma clearance was 741 ml·min−1·70 kg−1, which approaches normal liver blood flow after correction for the blood/plasma concentration ratio. Thus, diprafenone can be classified as a high extraction drug. Following oral administration, a dose-dependent increase in bioavailability from 10.9 (50 mg dose) to 32.5% (150 mg dose) was observed. The data suggest that diprafenone is subject to saturable hepatic first-pass metabolism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Economic Psychology 3 (1983), S. 347-365 
    ISSN: 0167-4870
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology , Economics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 61 (1904), S. 176-182 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the Electronic Structure of Phosphorus(III)-p-π-Bonded Systems: UV and PE Spectroscopic Investigation of Phosphaalkenes R—P=C(SiMe3)2UV and He-I-p.e. spectra of phosphaalkenes R—P=C(SiMe3)2 3 (R = Cl, F, OBut, SBut, NHBut, NHSiMe3, NEt2, NPr2i, 2, 2, 6, 6-Me4C5H6N, N(But)SiMe3, N(SiMe3)2, Me, But) are discussed. Assignment of π(P=C)- and n(P) ionization potentials agrees with UV data as well as semiempirical MNDO calculations. The alkyl-substituted species 31, m exhibit an inverse sequence of π(P=C) and n(P)-i.p.'s compared to theoretical predictions and recent spectroscopic studies, due to the π-electron accepting effect of the silyl substituents. Introduction of RO and RS substituents results in formation of a mesomeric 3-center-4-electron-π-system. Two different conformers of amino-phosphaalkenes can be distinguished which depend on the steric demand of the substituent, and differ in the orientation of the amine ligand in relation to the plane of molecular symmetry. Coexistence of both isomers is proved in case of 3h by temperature dependant UV studies. The existence of conformational isomerism provides an explanation for the remarkable differences in n.m.r. data of 3e-k.
    Notes: Die UV- und die He-I-Photoelektronenspektren der Methylenphosphane R—P=C(SiMe3)2 3 (R = Cl, F, OBut, NHBut, SBut, NHSiMe3, NEt2, NPr2i, 2, 2, 6, 6-Me4C5H6N, N(But)SiMe3, N(SiMe3)2, Me, But) werden diskutiert. Die Zuordnung der Ionisationspotentiale zu π(P=C)- bzw. n(P)-Orbitalen ist konsistent mit den UV-Daten sowie semieempirischen MNDO-Rechnungen. Die π-Akzeptorwirkung der Silylsubstituenten bewirkt bei den alkylsubstituierten Verbindungen 31, m eine Umkehr der Abfolge der π(P=C)- und n(P)-I.P.'s im Vergleich zu bisher untersuchten Phosphaalkenen sowie theoretischen Vorhersagen. Einführung von RO- bzw. RS-Substituenten in 3c, d fuhrt zur Ausbildung eines mesomeriestabilisierten 3-Zentren-4-Elektronen-π-Bindungssystems. Bei den Aminomethylenphosphanen 3e-k können in Abhängigkeit von der Raumerfüllung der Substituenten zwei unterschiedliche Konformere unterschieden werden, die sich durch die Stellung des Aminrestes bezüglich der Molekülsymmetrieebene unterscheiden. Die Koexistenz beider Konformere kann am Beispiel von 3h durch temperaturabhängige UV-Untersuchungen belegt werden. Die bemerkenswerten Unterschiede der 31P- und 13C-NMR-Daten von 3e-k können im Zusammenhang mit der beobachteten Konformationsisomerie erklärt werden.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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