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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 111 (1989), S. 9134-9135 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 196-201 (Nov. 1995), p. 1159-1164 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Synthetic human connecting peptide ; C-peptide immunoreactivity (CPR) ; urine CPR ; blood CPR ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A double-antibody radioimmunoassay method, using synthetic human connecting peptide as an immunizing antigen and standard, was evaluated for clinical assay of blood and urine samples. Normal fasting blood connecting peptide immunoreacivity (CPR) was 2.45±0.96 ng/ml, increasing promptly after a 50 g oral glucose load, but somewhat slower than insulin. Molar concentration of CPR exceeded that of insulin. CPR responses to glucose were subnormal in diabetics, very low in juvenile-type cases, and often poor in patients on insulin treatment. Fasting CPR levels were elevated in patients on corticosteroid treatment and with uraemia. A patient with insulin “auto-antibod” had high serum CPR. A considerable amount of CPR appeared in urine. Normal daily excretion of CPR was 1.52±0.55 μg/kg or 55.1±18.2 ng/mg creatinine. Urine CPR was very low in juvenile-type diabetics, and elevated in patients on corticosteroid treatment. The results confirm that blood and urine CPR are useful measures of the endocrine pancreatic function.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 14 (1992), S. 251-257 
    ISSN: 1279-8517
    Keywords: Length of the large intestine ; Diameter of the large intestine ; Size of the large intestine ; Barium enema examination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La longueur, le diamètre et la surface développée de chacun des six segments du colon ont été mesurés sur une série de 920 lavements barytés pratiqués chez des patients Japonais. Le colon transverse est le segment le plus long et le plus étendu en surface, suivi par le colon sigmoïde. Le diamètre du colon ascendant est le plus important, tandis que ceux du colon descendant et du sigmoïde sont les plus étroits. Des différences de taille du colon en fonction du sexe ont été observées. La longueur et la surface de la totalité du colon étaient toutes deux moins importantes chez les hommes que chez les femmes. Les longueurs du caecum, du colon ascendant, du colon transverse et du rectum, sont également moins importantes chez les hommes que chez les femmes. Les diamètres du colon descendant, du colon sigmoïde et du rectum sont plus importants chez les hommes que chez les femmes. La surface développée du colon ascendant et du colon transverse est moins étendue chez les hommes que chez les femmes, tandis que le total des surfaces du colon descendant, du colon sigmoïde et du rectum, est plus important chez les hommes que chez les femmes. La longueur totale du colon tend à augmenter avec l'âge. La longueur et la surface de l'ensemble du colon a également tendance à augmenter chez les femmes avec importance du morphotype.
    Notes: Summary Length, diameter and surface area of each of 6 segments of the large intestine were determined and calculated in 920 Japanese patients who underwent barium enema. Of the length and surface area measurements obtained, those of the transverse colon were the largest, followed by those of the sigmoid colon. The diameter of the ascending colon was the largest, while those of the descending colon and sigmoid colon were the smallest. There were various sex differences in size of the large intestine. Length and surface area of the entire large intestine in males were shorter and smaller respectively than those in females. Lengths of the cecum, ascending colon, transverse colon and rectum in males were shorter than those in females. Diameters of the descending colon, sigmoid colon and rectum in males were larger than those in females. Total surface areas of the ascending colon and transverse colon in males were smaller than those in females, while total surface areas of the descending colon, sigmoid colon and rectum in males were larger than those in females. Length of the entire large intestine tended to be increased with age. Length and surface area of the entire large intestine tended to be increased with an increase in physical dimensions in females.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Cette étude a montré la communication possible des liquides entre les régions paravertébrales thoracique et lombaire à travers le fascia endothoracique. Les observations de Lönnqvist à propos de la limite caudale de l'anesthésie paravertébrale thoracique semble pouvoir être remises en cause bien que n'ayons pas examiné de cadavre d'enfant [11]. Il y a des malentendus en ce qui concerne la diffusion du liquide dans le fascia endothoracique. Leur correction est importante pour l'application clinique ultérieure de l'anesthésie paravertébrale.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'injection d'un anesthésique local dans la région paravertébrales entraîne une analgésie unilatérale localisée (bloc paravertébral). On pouvait se demander si l'anesthésique local diffusait du niveau thoracique au niveau lombaire de la région paravertébrale. Le but de cette étude était de définir comment le liquide anesthésique gagnait la région paravertébrale lombaire, s'il le faisait. 12 cadavres ont été utilisés dans cette étude. 15 mm de colorant rouge ont été injectés dans la région paravertébrale des cadavres au niveau de la 11ème vertèbre thoracique. Les viscères ont ensuite été enlevés pour permettre l'examen de la diffusion du colorant. Le colorant diffusait dans le fascia endothoracique en arrière de la plèvre pariétale, puis vers le bas à l'intérieur du fascia, principalement le long des nerfs splanchniques. A la face supérieure du diaphragme, il diffusait latéralement dans le fascia, et pénétrait dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Dans la cavité abdominale, le colorant diffusait largement dans le fascia transversalis de telle sorte qu'il atteignait les nerfs subcostal, ilio-hypogastrique, ilio-inguinal, génito-fémoral, cutané latéral de la cuisse, et fémoral. Nous en avons conclu que le colorant pouvait passer de la région paravertébrale thoracique dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Cette étude montre la communication possible des liquides entre les régions paravertébrales thoracique et lombaire, et corrobore nos observations cliniques préalables. Le résultat en est important pour l'utilisation clinique ultérieure des blocs paravertébraux.
    Notes: Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: Aldose reductase ; diabetic retinopathy ; erythrocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Erythrocyte aldose reductase was determined in 90 NIDDM patients by a two-site ELISA using recombinant human aldose reductase. The level of aldose reductase did not correlate with age, duration of diabetes, fasting blood glucose and HbA1cof the patients. Among 38 patients with diabetes for more than 10 years, aldose reductase in those with retinopathy (including non-proliferative and proliferative) was significantly higher than in those without, while no difference in the means of the average HbA1c, maximum and minimum blood pressure levels was observed between the two groups. The results indicate that the level of aldose reductase in the erythrocyte of diabetic patients is associated with the presence of retinopathy.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0428
    Keywords: Keywords Cloning ; PPARγ ; insulin resistance ; thiazolidinediones ; cytokines ; TNF-α ; rat ; adipocyte ; glucose uptake.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptorγ (PPARγ). We hypothesized that the anti-diabetic mechanism of thiazolidinediones depends on the quantity of PPARγ in the insulin resistant state in which inflammatory cytokines play a part. Methods. We isolated rat PPARγ1 and γ2 cDNAs and examined effects of various cytokines and thiazolidinediones on PPARγ mRNA expression in rat mature adipocytes. Results. Various inflammatory cytokines, such as tumour necrosis factor-α (TNF-α), interleukin-1α (IL-1α), IL-1β, IL-6 and leukaemia inhibitory factor decreased PPARγ mRNA expression. In addition, hydrogen peroxide, lysophosphatidylcholine or phorbol 12-myristate 13-acetate also decreased the expression of PPARγ. The suppression of PPARγ mRNA expression caused by 10 nmol/l of TNF-α was reversed 60 % and 55 % by treatment with 10–4 mol/l of troglitazone and 10–4 mol/l of pioglitazone, respectively. The suppression of glucose transporter 4 mRNA expression caused by TNF-α was also reversed by thiazolidinediones. Associated with the change of PPARγ mRNA expression, troglitazone improved glucose uptake suppressed by TNF-α. Conclusion/interpretation. Our study suggests that inflammatory cytokines could be factors that regulate PPARγ expression for possible modulation of insulin resistance. In addition, we speculate that the regulation of PPARγ mRNA expression may contribute to the anti-diabetic mechanism of thiazolidinediones. [Diabetologia (1999) 42: 702–710]
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Key words Aldose reductase, diabetic retinopathy, erythrocyte.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Erythrocyte aldose reductase was determined in 90 NIDDM patients by a two-site ELISA using recombinant human aldose reductase. The level of aldose reductase did not correlate with age, duration of diabetes, fasting blood glucose and HbA1c of the patients. Among 38 patients with diabetes for more than 10 years, aldose reductase in those with retinopathy (including non-proliferative and proliferative) was significantly higher than in those without, while no difference in the means of the average HbA1c, maximum and minimum blood pressure levels was observed between the two groups. The results indicate that the level of aldose reductase in the erythrocyte of diabetic patients is associated with the presence of retinopathy. [Diabetologia (1994) 37: 328–330]
    Type of Medium: Electronic Resource
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