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  • 1
    Electronic Resource
    Electronic Resource
    The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: the Oslo Study (1994)
    Springer
    Diabetologia 37 (1994), S. 579-584 
    Details
    ISSN: 1432-0428
    Keywords: Key words IDDM, nerve conduction velocity, neuropathy, intensified insulin treatment.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have investigated the effect of long-term strict glycaemic control on peripheral and autonomic nerve function in 45 IDDM patients (age 18–42 years, diabetes duration 7–23 years) without clinical signs of neuropathy or other neurological disease. They were randomly assigned to treatment either with continuous insulin infusion, multiple injections (4–6 times daily), or conventional treatment (twice daily) for 4 years and followed prospectively for 8 years. Motor and sensory nerve conduction velocities were measured at the start and after 8 years. Autonomic nerve function tests were performed only once, after 8 years. A significant reduction of nerve conduction velocity was observed during 8 years in patients with mean HbA1 more than 10 % (n =12, group mean 10.9 %, range 10.1–13.2 %) compared to patients with HbA1 less than 10 % (n =33, group mean 9.0 %, range 7.5–9.9 %). Change of motor nerve conduction velocity in the peroneal nerve was: –4.8±4.9 (SD) vs –2.2±5.3 m/s (p〈0.01). Change of motor nerve conduction velocity in the posterior tibial nerve was: –6.8±5.7 vs –3.9±5.1 m/s (p〈0.05). No significant changes were observed in the ulnar nerve. Change of sensoric nerve conduction velocity in the sural nerve was: –8.9±8.0 vs –4.6±5.3 m/s (p〈0.05). Multiple regression analysis showed that a change in HbA1 of 1 % resulted in a 1.3 m/s change in nerve conduction velocity during 8 years. A significantly lowered heart-rate variation during deep breathing (p〈0.05) and heart-rate response to standing (p〈0.01) was found in patients with HbA1 more than 10 % compared to patients with HbA1 less than 10 %. This study confirms that the long-term lowering of blood glucose retards the deterioration in nerve conduction velocity observed in the diabetic nerve. [Diabetologia (1994) 37: 579–584]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403376
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of 8 years of strict glycaemic control on peripheral nerve function in IDDM patients: the Oslo study (1994)
    Springer
    Diabetologia 37 (1994), S. 579-584 
    Details
    ISSN: 1432-0428
    Keywords: IDDM ; nerve conduction velocity ; neuropathy ; intensified insulin treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have investigated the effect of long-term strict glycaemic control on peripheral and autonomic nerve function in 45 IDDM patients (age 18–42 years, diabetes duration 7–23 years) without clinical signs of neuropathy or other neurological disease. They were randomly assigned to treatment either with continuous insulin infusion, multiple injections (4–6 times daily), or conventional treatment (twice daily) for 4 years and followed prospectively for 8 years. Motor and sensory nerve conduction velocities were measured at the start and after 8 years. Autonomic nerve function tests were performed only once, after 8 years. A significant reduction of nerve conduction velocity was observed during 8 years in patients with mean HbA1 more than 10% (n=12, group mean 10.9%, range 10.1–13.2%) compared to patients with HbA1 less than 10% (n=33, group mean 9.0%, range 7.5–9.9%). Change of motor nerve conduction velocity in the peroneal nerve was: −4.8±4.9 (SD) vs −2.2±5.3 m/s (p〈0.01). Change of motor nerve conduction velocity in the posterior tibial nerve was: −6.8±5.7 vs −3.9±5.1 m/s (p〈0.05). No significant changes were observed in the ulnar nerve. Change of sensoric nerve conduction velocity in the sural nerve was: −8.9±8.0 vs −4.6±5.3 m/s (p〈0.05). Multiple regression analysis showed that a change in HbA1 of 1% resulted in a 1.3 m/s change in nerve conduction velocity during 8 years. A significantly lowered heart-rate variation during deep breathing (p〈0.05) and heart-rate response to standing (p〈0.01) was found in patients with HbA1 more than 10% compared to patients with HbA1 less than 10%. This study confirms that the long-term lowering of blood glucose retards the deterioration in nerve conduction velocity observed in the diabetic nerve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403376
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Clinical effects of hyposensitization using a purified allergen preparation from Timothy pollen as compared to crude aqueous extracts from Timothy pollen and a four-grass pollen mixture respectively (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Most extracts used in hyposensitization are complex and ill-defined mixtures of a large number of antigenic components. A highly refined (purified) and well-characterized allergen preparation from Timothy pollen (Phleum pratense) is now available.This paper describes the results of hyposensitization for 3 years comparing the purified preparation Timothy N. the crude extract Timothy O and a four-grass mix in sixty patients with allergic rhinitis due to grass pollen. The sixty patients were randomized into three groups and compared with a control group not hyposensitized. All three groups showed a significant decrease in clinical symptoms compared with the control group. The Timothy N group had a significantly higher nasal tolerance shown by nasal challenge test after 3 years' treatment than the group treated with the crude extract (P= 0.05). In addition, the Timothy-N-treated patients needed significantly less antihistaminic medication than the patients having received the crude extract or the four-grass mix (P=0.02 and P= 0.01 respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02609.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hyposensitization (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 35 (1980), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Most extracts used in hyposensitization (immunotherapy) are complex and ill-denned mixtures of a large number of non-antigenic and antigenic components, only a few of the latter being of significance for allergy and allergen specific immunotherapy. A new purified and well-characterized allergen preparation from timothy pollen is now available, and it has been shown to be superior to the corresponding crude aqueous extract in the diagnosis of IgE-mediated human allergy to timothy pollen.This paper describes the results of hyposensitization for 2 years, with the purified preparation and the crude extract compared. The changes in in vivo and in vitro tests Following this treatment in 40 patients with allergic rhinitis due to grass pollen are reported.Both patient groups showed a significant decrease in clinical symptom scores when compared with a control group during the grass pollen season. For all groups the symptom scores correlated well with atmospheric pollen counts. Nasal challenge tests showed a significant increase in nasal tolerance to timothy pollen after 2 years of treatment, but nasal tolerance was unchanged in the control group. Nasal function as a criterion for evaluating the effect of specific hyposensitization is discussed.Serum concentrations of timothy pollen-specific IgE antibodies showed a significant decrease for the group treated with the purified preparation and a slighter and non-significant reduction for the other treated group. There was no significant change in total serum IgE levels.The results indicate that the purified preparation is preferable to the crude aqueous extract in hyposensitization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1980.tb01722.x
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    Paper (German National Licenses)
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