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  • 1
    Electronic Resource
    Electronic Resource
    Concerning Structural Limitations in the Relationship between Trityl Cation Stability and Reactivity1 (1966)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 4747-4749 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00972a054
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  • 2
    Electronic Resource
    Electronic Resource
    Lectin-binding sites of the human pituitary adenoma cells by means of the ferritin-labeling technique (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 67-74 
    Details
    ISSN: 1432-0533
    Keywords: Ferritin labeled lectin ; Human pituitary adenoma ; Functioning adenoma ; Non-functioning adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lectin-binding sites of the human pituitary adenoma cells were examined by electron microscopy in correlation with their functional states. In this study used were 37 cases of the human pituitary adenomas which had been operated in our clinics from 1977 to 1979. They were divided into four groups: 13 cases of PRL-producing adenomas, nine of hGH-producing adenomas, three of ACTH-producing adenomas, and 12 of hormonal non-functioning adenomas. In parallel with the detection of the lectinbinding sites by means of the ferritin-labeling method, the basal levels of their secreting hormones were determined by the radioimmunoassay technique, and their producing hormones were characterized light microscopically by the immunocytochemical HRP-labeling technique. The present study clearly shows that the ferritinlabeled, lectin-binding sites of the human pituitary adenoma cells prefixed with aldehyde are different in number between PRL- or hGH-producing adenoma cells and non-functioning ones. Morphologically resemblin, non-functioning adenoma cells and mixed somatotrophic and lactotrophic adenoma cells are definitely distinguished from each other by the findings of the ferritin-labeled RCA-binding sites' distribution pattern. Lectins have been proved very useful to evaluate the membrane characteristics of the human pituitary adenoma cells in association with their functional states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691184
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  • 3
    Electronic Resource
    Electronic Resource
    Selective vulnerability in the gerbil hippocampus following transient ischemia (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 201-208 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Selective vulnerability ; Hippocampus ; Cell death ; Gerbils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following brief ischemia, the Mongolian gerbil is reported to develop unusual hippocampal cell injury (Brain Res 239:57–69, 1982). To further clarify this hippocampal vulnerability, gerbils were subjected to ischemia for 3, 5, 10, 20, and 30 min by bilateral occlusion of the common carotid arteries. They were perfusion-fixed after varying intervals of survival time ranging from 3 h up to 7 days. Following brief ischemia (5–10min), about 90% of the animals developed typical hippocampal damage. The lesion was present throughout the extent of the dorsal hippocampus, whereas damage outside the hippocampus was not observed. Each sector of the hippocampus showed different types of cell reaction to ischemia. Ischemic cell change was seen in scattered CA4 neurons, and reactive change was found in CA2, whereas CA1 pyramidal cells developed a strikingly slow cell death process. Ischemia for 3 min did not produce hippocampal lesion in most cases. Following prolonged ischemia (20–30min), brain injury had a wide variety in its extent and distribution. These results revealed that the gerbil brief ischemia model can serve as an excellent, reliable model to study the long-known hippocampal selective vulnerability to ischemia. Delayed neuronal death in CA1 pyramidal cells was confirmed after varying degrees of ischemic insult. These findings demonstrated that the pathology of neuronal injury following brief ischemia was by no means uniform nor simple.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691853
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  • 4
    Electronic Resource
    Electronic Resource
    Delayed neuronal death in the rat hippocampus following transient forebrain ischemia (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 139-147 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Cell death ; Endoplasmic reticulum ; Hippocampus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual, slowly progressing neuronal damage has been reported to occur in the gerbil hippocampus following ischemia (Kirino 1982). Delayed neuronal death following ischemia has also been noticed in the rat four-vessel occlusion model (Pulsinelli et al. 1982). By light microscopy this slow neuronal injury in the rat was not different from the previously known neuronal ischemic cell change. This report lead us to the question as to whether neurons in the rat hippocampus are damaged rapidly following an initial latent period or deteriorate slowly and progressively until they display overt changes. To clarify this point, observation was done on the hippocampal CA1 sector of the rat following ischemia. Rats were subjected to four-vessel occlusion, and those which developed ischemic symptoms were perfusion-fixed. Although the change appeared very slowly and lacked microvacuolation of the cytoplasm, neuronal alteration was practically not different from classical ischemic cell change. By electron microscopy, however, the change was detectable when the neurons still appeared intact by light microscopy. An increase in the membranous organelles and deposition of dark substances were the initial manifestations. It seemed that the CA1 neurons deteriorated very slowly and progressively, and that they retained partial viability in the initial phase of the change. In spite of the difference in light-microscopic findings, the mechanisms underlying delayed neuronal death in the rat and gerbil hippocampus seemed to be identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695577
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular characterization of a JC virus (Sap-1) clone derived from a cerebellar form of progressive multifocal leukoencephalopathy (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 105-112 
    Details
    ISSN: 1432-0533
    Keywords: Polyomavirus JC ; Progressive multifocal leukoencephalopathy (PML) ; Cerebellar PML ; Molecular characterization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by polyomavirus JC (JCV). In the majority of cases of PML the cerebrum is mainly affected (cerebral PML) but on rare occasions lesions are restricted to the cerebellum and brain stem (cerebellar PML). We report a rare cerebellar PML case which occurred in a Japanese patient undergoing prolonged hemodialysis treatment. To understand the molecular basis of the viral tissue tropism, we molecularly cloned JCV DNA and compared it with those of cerebral PML. Of ten clones analyzed nine showed identical fragment patterns after digestion with various restriction endonucleases, and we designated these clones Sap-1. It could be shown that the basic structures of the regulatory regions are similar between Sap-1 and isolates from cerebral PML. Restriction endonuclease mapping analysis was used to examine the genetic relationship between Sap-1 and urine-derived isolates containing the archetypal regulatory sequence. We found that Sap-1 was genetically related to an archetypal JCV isolate in Japan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308469
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  • 6
    Electronic Resource
    Electronic Resource
    Tight junctions in choroid plexus papillomas (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 159-160 
    Details
    ISSN: 1432-0533
    Keywords: Tight junction ; Choroid plexus papilloma ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four cases of choroid plexus papilloma (CPP) obtained at the time of surgical excision were examined by electron microscopy and compared with normal choroid plexus (CP) of mouse and chick. In apical tight junctions fusion of the two outer leaflets of the adjacent cytoplasmic membrane was verified as in CP. This fact suggests that there is a blood-CSF barrier not only in CP but also in CPP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691895
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  • 7
    Electronic Resource
    Electronic Resource
    Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 209-218 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Cell death ; Hippocampus ; Endoplasmic reticulum ; Ribosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual, delayed neuronal death (DND) has been noticed in the hippocampus of the Mongolian gerbil following brief ischemia (Kirino 1982). On day 1 following 5–10min of ischemia, light microscopy showed the CA1 pyramidal cells unchanged. On day 2, the cells showed massive growth of membranous cytoplasmic organelles instead of overt cellular disintegration. These neurons were destroyed extensively by day 4 after ischemic insult. Following longer ischemia (20–30min), however, the changes in the CA1 pyramidal cells appeared faster and resembled the wellcharacterized ischemic cell change (ICC). To further clarify the differences between ICC and DND, gerbils were submitted to transient 5–30min ischemia. They were perfusion-fixed following a given survival period and then processed for electron microscopy. Following transient ischemia, specimens showed slow cell changes with growth of cisterns of the endoplasmic reticulum (ER). In some CA1 neurons, the cytoplasm was shrunken and darkly stained, but they also displayed accumulation of ER cisterns. Occasionally, the CA1 cells demonstrated highly shrunken dark perikarya, no different than in ICC. These results indicate that DND seems to be the typical disease process of the CA1 sector and that a severer insult makes the change faster and more similar to ICC. ICC seems to occur when the CA1 pyramidal cells are damaged so severely that they cannot react with proliferous activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691854
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  • 8
    Electronic Resource
    Electronic Resource
    Brain stem haemorrhage during transsphenoidal surgery (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 188-191 
    Details
    ISSN: 0942-0940
    Keywords: Brain stem haemorrhage ; dural arteriovenous malformation ; pituitary adenoma ; transsphenoidal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report a case of pituitary adenoma associated with dural arteriovenous malformation (AVM), which caused brain stem haemorrhage during transsphenoidal surgery. The manoeuvre of increasing the endexpiratory pressure in order to push the suprasellar component of the adenoma down to the sella turcica could be the reason of this bleeding. The authors therefore recommend that in cases of such a combination any manoeuvres which are likely to increase the intracranial venous pressure or otherwise affect the intracranial pressure, are avoided. The dural AVM spontaneously regressed after haemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401851
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  • 9
    Electronic Resource
    Electronic Resource
    The temporo-polar approach to basilar artery aneurysms with or without zygomatic arch translocation (1994)
    Springer
    Acta neurochirurgica 130 (1994), S. 14-19 
    Details
    ISSN: 0942-0940
    Keywords: Basilar artery aneurysm ; temporo-polar approach ; zygomatic approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the publication of the temporo-polar approach to basilar artery aneurysms by Sano (1980 and 1987), various modifications of the approach were reported. The approach provides a better view and a wider operating field than the subtemporal or pterional ones. Usually the approach does not need temporary removal of the zygomatic arch. If however, a basilar tip aneurysm is located very high above the posterior clinoid, temporary removal of the zygomatic arch is necessary which is sutured back to its original position at the end of the operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405498
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  • 10
    Electronic Resource
    Electronic Resource
    Diagnosis and treatment of tumours in the pineal region (1976)
    Springer
    Acta neurochirurgica 34 (1976), S. 153-157 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a series of 3.072 cases of intracranial neoplasms up to the end of 1973 there were 82 tumours in the pineal region (2.7%), excluding meningiomas of the falx and tentorium. More than half (forty seven) were pinealomas (two cell pattern type tumours, and pineoblastomas), twelve were teratomas, eight were ependymomas, three were epidermoids, and the remainder were gliomas. In addition to ventriculography, millipore filter-cell culture of cerebrospinal fluid, and fibre ventriculoscopy were found useful for diagnosis. Most of the patients were treated by surgery followed by radiotherapy. Results with the pinealomas were fairly good, the one year, five year, and ten year survival rates being 87.5%, 71.4%, and 33.3% in those below the age of 15 years, and 80.0%, 46.2%, and 12.5% in those above that age. The radiosensitivity of pinealomas and the beneficial effect of reduction of tumour bulk by direct surgery may both be important factors in the achievement of good results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405869
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