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  • 1
    Electronic Resource
    Electronic Resource
    Heterosynaptic postactivation potentiation in hippocampal CA 3 neurons: Long-term changes of the postsynaptic potentials (1979)
    Springer
    Experimental brain research 37 (1979), S. 217-229 
    Details
    ISSN: 1432-1106
    Keywords: CA 3 ; Postactivation potentiation ; Longlasting ; EPSP/IPSP Changes ; Heterosynaptic potentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CA 3 neurons were excited synaptically by stimulation in the dentate hilus and the stratum radiatum of CA 1 in guinea pig hippocampal slices. Following repetitive stimulation (10–20 c/s, 10 s) of either stimulation site, the amplitudes of orthodromic population spikes or the probability of unitary discharges increased. Changes of the intracellularly recorded potentials were either (a) increased EPSP amplitudes associated with decreased IPSP amplitudes, or (b) increased IPSP amplitudes. A cell showing enhanced IPSPs after repetitive activation could respond with increased EPSP amplitudes and decreased IPSP amplitudes upon further repetitive activation. The potentiation, which was always preceded by a 5–10 min depression, lasted up to 3 h. This potentiation was heterosynaptic, since the responses to the non-stimulated input also changed and since the inputs were found to excite the pyramidal cells through separate synapses in double shock experiments. The heterosynaptic mode of the potentiation as well as the changes of the IPSPs indicate that not only the excitatory pathway but also the inhibitory pathway must be considered in explaining postactivation potentiation in this hippocampal field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237709
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Slow synaptic inhibition in relation to frequency habituation in dentate granule cells of rat hippocampal slices (1989)
    Springer
    Experimental brain research 78 (1989), S. 233-242 
    Details
    ISSN: 1432-1106
    Keywords: Hoppocampus ; Granule cells ; Long lasting inhibition ; Frequency habituation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In paired pulse stimulation experiments the mechanism underlying frequency habituation of postsynaptic potentials in dentate granule cells of rat hippocampal slices was studied by measuring extra and intracellular potentials as well as changes in extracellular calcium ([Ca2+]0) and potassium concentrations ([K+]0). Orthodromic stimulation of the perforant path induced in most granule cells a late, slow hyperpolarization (SH), lasting for up to 1.2 s. During the SH the membrane conductance was increased by up to 40%. The reversal potential of the SH was around -90 mV and varied with the [K+]0. Frequency habituation was seen in all cells with the SH, whereas cells which display frequency potentiation had no SH. Lowering of [Ca2+]0 reversed paired pulse induced frequency habituation into frequency potentiation at [Ca2+]0 levels where the SH disappeared. Phaclofen blocked the SH and reversed frequency habituation into frequency potentiation. Elevating [Mg2+]0 also reversed frequency habituation into frequency potentiation and reduced the SH. We conclude that the SH represents a late, slow IPSP which is responsible for frequency habituation in dentate granule cells. We noted that during repetitive stimulation the SH soon started to fade. This effect can in part be attributed to extracellular K+-accumulation as suggested by the K+-dependence of the slow IPSP and the observations of changes in [K+]0 during repetitive stimulation. This could explain why frequency habituation reverses into frequency potentiation during repetitive stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228895
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    NMDA receptor antagonists reduce medial, but not lateral, perforant path-evoked EPSPs in dentate gyrus of rat hippocampal slice (1990)
    Springer
    Experimental brain research 83 (1990), S. 172-177 
    Details
    ISSN: 1432-1106
    Keywords: Synaptic transmission ; Excitatory amino acids ; NMDA receptor antagonists ; Hippocampal formation ; Long-term potentiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary NMDA receptor antagonists produced differential effects on medial and lateral perforant path-evoked excitatory postsynaptic potentials (EPSPs) recorded in the dentate gyrus molecular layer of hippocampal slices. D-(-)-2-amino-5-phosphonovaleric acid (D(-)APV) and 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) significantly reduced the peak amplitude and total area, but not the initial negative slope, of the medial perforant path-evoked EPSP. Neither antagonist affected any component of the lateral perforant path-evoked EPSP. In contrast, population spikes evoked by stimulation of either pathway were depressed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232206
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    Paper (German National Licenses)
    Fulltext
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