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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine (1996)
    Springer
    Diabetologia 39 (1996), S. 263-269 
    Details
    ISSN: 1432-0428
    Keywords: Keywords N-acetylcysteine ; glutathione ; tumour necrosis factor α ; diabetic neuropathy ; motor nerve conduction velocity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor α (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velocity (MNCV) was significantly decreased in streptozotocin-induced-diabetic Wistar rats compared to control rats. Oral administration of NAC reduced the decline of MNCV in diabetic rats. Structural analysis of the sural nerve disclosed significant reduction of fibres undergoing myelin wrinkling and inhibition of myelinated fibre atrophy in NAC-treated diabetic rats. NAC treatment had no effect on blood glucose levels or on the nerve glucose, sorbitol and cAMP contents, whereas it corrected the decreased GSH levels in erythrocytes, the increased lipid peroxide levels in plasma and the increased lipopolysaccharide-induced TNF activity in sera of diabetic rats. Thus, NAC inhibited the development of functional and structural abnormalities of the peripheral nerve in streptozotocin-induced diabetic rats. [Diabetologia (1996) 39: 263–269]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418340
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine (1996)
    Springer
    Diabetologia 39 (1996), S. 263-269 
    Details
    ISSN: 1432-0428
    Keywords: N-acetylcysteine ; glutathione ; tumour necrosis factor α ; diabetic neuropathy ; motor nerve conduction velocity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor α (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velocity (MNCV) was significantly decreased in streptozotocin-induced-diabetic Wistar rats compared to control rats. Oral administration of NAC reduced the decline of MNCV in diabetic rats. Structural analysis of the sural nerve disclosed significant reduction of fibres undergoing myelin wrinkling and inhibition of myelinated fibre atrophy in NAC-treated diabetic rats. NAC treatment had no effect on blood glucose levels or on the nerve glucose, sorbitol and cAMP contents, whereas it corrected the decreased GSH levels in erythrocytes, the increased lipid peroxide levels in plasma and the increased lipopolysaccharide-induced TNF activity in sera of diabetic rats. Thus, NAC inhibited the development of functional and structural abnormalities of the peripheral nerve in streptozotocin-induced diabetic rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418340
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibitory effect of troglitazone on diabetic neuropathy in streptozotocin-induced diabetic rats (1998)
    Springer
    Diabetologia 41 (1998), S. 1321-1326 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Troglitazone ; diabetic neuropathy ; free radical scavenger ; tumour necrosis factor-α (TNF-α) ; motor nerve conduction velocity (MNCV).
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Free-radical scavengers and inhibitors of tumour necrosis factor-α (TNF-α) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazolidinedione, on diabetic neuropathy, since it also is a free-radical scavenger and a TNF-α inhibitor. Rats were fed powder chow mixed with troglitazone at 0.5 % and 0.125 % ad libitum. Although blood glucose concentrations were remarkably higher and body weight lower in diabetic than in nondiabetic rats, troglitazone had no effect on these throughout the 24-week experiment. Serum lipoperoxide concentrations, tibial nerve lipoperoxide content and serum TNF-α activity induced by lipopolysaccharide was increased in diabetic rats, but inhibited in troglitazone-treated rats. Motor nerve conduction velocity (MNCV) of the tibial nerve slowed in diabetic rats, compared with that in nondiabetic rats. On the other hand, the slowed MNCV was (p 〈 0.05–0.01) inhibited after weeks 12 and 16 of the experiment in diabetic rats treated with high and low doses of troglitazone, respectively. Morphometric analysis showed that troglitazone suppressed the decrease of the myelinated fibre area (p 〈 0.05), axon/myelin ratio (p 〈 0.01) and fascicular area (p 〈 0.05) and suppressed the increase of myelinated fibre density (p 〈 0.001) in diabetic rats. These results indicate that troglitazone has a beneficial effect on peripheral neuropathy in STZ-induced diabetic rats irrespective of blood glucose concentrations. [Diabetologia (1998) 41: 1321–1326]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051072
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  • 4
    Electronic Resource
    Electronic Resource
    Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 388-395 
    Details
    ISSN: 1432-0533
    Keywords: Parvalbumin ; Ca2+-binding protein ; Interneuron ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical localization of the Ca2+-binding protein parvalbumin (PV) was investigated in the adult human central nervous system (CNS). The antiserum against purified rat skeletal muscle PV specifically recognized certain neuronal populations and their processes. Strongly positive were Purkinje, basket and stellate cells of the cerebellum, cerebral cortical nonpyramidal cells, and neurons in the thalamic reticular and ventrolateral nuclei, subthalamic nucleus, lateral and medial geniculate bodies, vestibular and cochlear nuclei, spinal trigeminal nucleus, cuneate and gracile nuclei, and dorsal nucleus of Clarke. Negative were cortical pyramidal neurons, neurons of the autonomic nerves, and neurons in the caudate nucleus, putamen, dentate nucleus, inferior olive, and substantia gelatinosa. The number and size of PV-immunoreactive neurons were significantly decreased in Alzheimer's disease. However, the decrease was not disease specific.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293459
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  • 5
    Electronic Resource
    Electronic Resource
    Axonal polyglucosan body in the ventral posterolateral nucleus of the human thalamus in relation to ageing (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 9-12 
    Details
    ISSN: 1432-0533
    Keywords: Axon ; Polyglucosan body ; Sensory neuron ; Thalamus ; Ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Axonal polyglucosan bodies in myelinated axons in the ventral posterolateral nucleus of the human thalamus (VPL) are described. These axonal inclusions were distributed exclusively in the dorsolateral part of the caudal VPL, and their arrangement may be associated with fibres originating from the gracile nucleus. They were not observed in patients under age of 50, and appeared to increase in number and size with advancing age. It is suggested that axonal polyglucosan bodies are an ageing phenomenon of the secondary sensory fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688332
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  • 6
    Electronic Resource
    Electronic Resource
    Matrix ENDOR of tyrosine D^+ in oriented Photosystem II membranes
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 1144 (1993), S. 426-433 
    Details
    ISSN: 0005-2728
    Keywords: Delocalized spin model ; ENDOR ; Photosynthesis ; Photosystem II ; Surrounding proton ; Tyrosine D^+
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2728(93)90130-8
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  • 7
    Electronic Resource
    Electronic Resource
    Functional properties of the stratum corneum in patients with diabetes mellitus: similarities to senile xerosis (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Although diabetes mellitus is known to induce many pathophysiological changes in the skin, none of the earlier studies has focused on the state of the stratum corneum (SC) in patients with diabetes. In our previous report on a diabetic mouse model, we described a decreased SC hydration state and abnormalities in the function of the sebaceous gland together with a normally retained barrier function of the SC.Objectives  To examine the functional changes of the SC in patients with diabetes.Methods  The following values were measured in 49 patients with diabetes: fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c); skin surface lipid level on the forehead; and high-frequency conductance (HFC) and transepidermal water loss (TEWL) of the SC of the volar forearm and extensor surface of the lower leg. These functions of the SC were compared in two pairs of patient groups, i.e. between groups with high and low FPG, and between groups with high and low HbA1c.Results  The HFC levels on the extensor leg and volar forearm were significantly lower in the group with high FPG (FPG 〉 110 mg dL−1) than in the group with low FPG (FPG 〈 110 mg dL−1), although TEWL values were almost the same in these two groups. The skin surface lipids on the forehead were significantly lower in the former than in the latter. The HFC did not differ significantly between the group with high HbA1c (HbA1c 〉 5·8%) and the group with low HbA1c (HbA1c 〈 5·8%), whereas the TEWL of the volar forearm was slightly lower in the former than in the latter.Conclusions  These new results as well as our earlier results with diabetic mice suggest that patients with diabetes mellitus tend to show a reduced hydration state of the SC together with decreased sebaceous gland activity, without any impairment of the SC barrier function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06756.x
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  • 8
    Electronic Resource
    Electronic Resource
    EPR study of charge equilibrium at low temperatures in the S"2 state of oxygen-evolving photosystem II particles
    Amsterdam : Elsevier
    FEBS Letters 217 (1987), S. 134-138 
    Details
    ISSN: 0014-5793
    Keywords: Charge recombination ; Decay kinetics ; EPR signal II"s ; Manganese multiline ; PS II particle
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(87)81257-7
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  • 9
    Electronic Resource
    Electronic Resource
    Epitaxial growth of tin thin films on a potassium chloride substrate
    Amsterdam : Elsevier
    Journal of Crystal Growth 47 (1979), S. 527-532 
    Details
    ISSN: 0022-0248
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0248(79)90135-0
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  • 10
    Electronic Resource
    Electronic Resource
    Pressure effect on the melting point of alkali metals
    Amsterdam : Elsevier
    Solid State Communications 46 (1983), S. 661-663 
    Details
    ISSN: 0038-1098
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1098(83)90208-9
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