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  • 1
    Electronic Resource
    Electronic Resource
    The effects of HA1077 on the cerebral circulation after subarachnoid haemorrhage in dogs (1991)
    Springer
    Acta neurochirurgica 110 (1991), S. 185-188 
    Details
    ISSN: 0942-0940
    Keywords: HA1077 ; cerebral vasospasm ; subarachnoid haemorrhage ; cerebral blood flow ; calcium antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the effects of the recently developed calcium antagonist HA1077 on cerebral haemodynamics during the chronic stage of the two-haemorrhage canine model system of vasospasm. Regional cerebral blood flow (rCBF), regional cerebral blood velocity and regional cerebral blood volume in the canine parietal cortex were measured by Laser-doppler flowmeter. On the 7th day after the initial injection of autogenous blood, subarachnoid haemorrhage (SAH) produced a significant decrease in rCBF (59% of control, p〈0.05) and Hood velocity (48% of control, p〈0.05), with no remarkable change in blood volume (108% of control). Bolus intravenous administration of HA1077 (0.1–0.3 mg/kg) dose-dependently increased the rCBF and blood velocity, without significantly changing the blood volume on Day 7 after SAH. HA1077 improves haemodynamic function manifested by an increase in rCBF and velocity in this SAH model, and may be suitable for the treatment of vasospasm in patients with SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400689
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The relationship between myocardial oxygen consumption and total work obtained by a new left ventricular model (1984)
    Springer
    Basic research in cardiology 79 (1984), S. 363-374 
    Details
    ISSN: 1435-1803
    Keywords: oxygen consumption ; internal work ; external work ; source resistance ; afterload impedance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between myocardial oxygen consumption ( $$M\dot VO_2 $$ ) and left ventricular work was examined experimentally, assuming that the left ventricle is equivalent to an electrical current source generator consisting of parallel source resistance (Ri) and constant generator current (I0). The internal and external work can be calculated as (Ri×I1 2) and (Rp×I2 2) in this model, where I1 is current of source resistance, Rp is peripheral resistance and I2 is cardiac output. The experiments were performed with a blood-perfused isolated ejecting canine heart preparation in which the hydraulic model, simulated to an aortic input impedance, was attached to the aortic root. The peripheral resistance was changed in a stepwise fashion and left ventricular pressure, cardiac output and $$M\dot VO_2 $$ were measured. The calculated total work showed a close linear correlation with the $$M\dot VO_2 $$ which suggested that the left ventricle can be regarded as a current source generator and the total work as a main mechanical factor in determining the $$M\dot VO_2 $$ .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908037
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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