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  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylcholine antibodies in pulmonary infection (1990)
    Springer
    Medical microbiology and immunology 179 (1990), S. 205-214 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phosphorylcholine (PC) antibodies in serum from patients with pulmonary infection, and from normal individuals, were studied. Anti-PC antibodies were detectable in the serum from normal individuals at mean concentrations of 320 μg/ ml for the IgG class and 110 μg/ml for the IgM class. Concentrations of anti-PC antibodies which were higher than normal for both the IgG and IgM classes were observed in the serum in pulmonary infection (1,440 μg/ml and 210 μg/ml, respectively). Despite the significant difference in the concentration of anti-PC antibodies, the PC-specific B cell precursor frequency in the peripheral blood lymphocytes showed no difference between normal individuals and the patients with pulmonary infection, or between the acute phase and the chronic phase in a single patient with chronic pulmonary infection. Serologically, the purified IgG anti-PC antibody did not share the cross-reactive idiotype of TEPC 15, which is the most common idiotype of the murine anti-PC antibodies. However, the purified IgM anti-PC antibody expressed a very weak cross-reactive idiotype of TEPC 15. It appears from these studies that human anti-PC antibodies may play an important biological role in pulmonary infection by microorganisms which possess a PC determinant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195251
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  • 2
    Electronic Resource
    Electronic Resource
    Gamma-D-glutamylglycine and cis-2,3-piperidine dicarboxylate as antagonists of excitatory amino acids in the hippocampus (1984)
    Springer
    Experimental brain research 55 (1984), S. 351-358 
    Details
    ISSN: 1432-1106
    Keywords: Excitatory amino acid ; Antagonist ; Gamma-D-glutamylglycine ; Cis-2,3-piperidine dicarboxylate ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actions of gamma-D-glutamylglycine (DGG) and cis-2,3-piperidine dicarboxylate (PDA) were studied in thin hippocampal sections of the guinea pig by intracellular recording. DGG and PDA suppressed depolarizations induced in CA3 neurons by short pulses of L-aspartate (Asp), D-homocysteat (DH) or L-glutamate (Glu). Asp-and DH-responses were more susceptible to the antagonists than were Glu-responses. The sensitivity difference between Glu-responses and Asp-or DH-responses was not so pronounced that these antagonists could be used to differentiate between Glu-mediated and Asp-mediated synapses. Glu and Asp pulses induced long hyperpolarizing deflections in some neurons. In about half of these neurons, PDA and DGG were without effect on the hyperpolarizing responses. The depolarizing action of gamma-amino butyric acid was unaffected by DGG and PDA. These antagonists blocked excitatory postsynaptic potentials induced by fimbrial stimulation. These results suggest that DGG and PDA are relatively specific antagonists of excitatory amino acids in the hippocampus, and that Glu (or Asp) is the neurotransmitter released from axons of CA3 neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237285
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  • 3
    Electronic Resource
    Electronic Resource
    Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus (1983)
    Springer
    Experimental brain research 51 (1983), S. 128-134 
    Details
    ISSN: 1432-1106
    Keywords: 2-Amino-4-phosphonobutyric acid ; Hippocampus ; Glutamate receptor ; Mossy fiber
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The action of 2-amino-4-phosphonobutyric acid (APB) on mossy fiber-induced excitation in CA3 neurons was studied in vitro with thin sections of guinea pig hippocampus. D- and DL-APB suppressed field potentials induced in regio CA3 by granular layer stimulation. Threshold concentration of DL-APB to induce the suppression was 2–5 μM. D-APB was about 10-fold less potent than DL-APB. Field potentials induced by fimbrial stimulation were much less affected. DL-APB was without effect on antidromic activation of granule cells. 2-Amino-phosphonovaleric acid had a similar but less potent action. Gamma-D-glutamylglycine and cis-2,3-piperidine dicarboxylic acid were almost ineffective. DL-APB suppressed excitatory postsynaptic potentials recorded intracellularly from CA3 neurons in response to granular layer stimulation but caused no marked changes in resting potentials, action potentials and membrane conductance. Single cell discharges induced by iontophoretic administration of glutamate (Glu) or aspartate (Asp) were unaffected when mossy fiber-induced excitation was suppressed by D- or DL-APB. DL-APB had no suppressing action on Glu- or Asp-induced depolarizing potentials. These results indicate that APB is a relatively specific blocker of synaptic transmission between mossy fibers and CA3 neurons, and that this action does not result from blockade of receptors for Glu or Asp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236810
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  • 4
    Electronic Resource
    Electronic Resource
    Postsynaptic inhibitory actions of catecholamines and opioid peptides in the bed nucleus of the stria terminalis (1981)
    Springer
    Experimental brain research 41 (1981), S. 264-270 
    Details
    ISSN: 1432-1106
    Keywords: Norepinephrine ; Enkephalin ; Catecholamine ; Bed nucleus of the stria terminalis ; Amygdala
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of catecholamines, enkephalins and related compounds on electrical activity of the bed nucleus of stria terminalis (BST) were studied in vitro on thin BST sections prepared from guinea pig brains. Norepinephrine (NE) and epinephrine (E) suppressed field potentials elicited by a single shock to the stria terminalis (ST). The effects of NE and E were mimicked by phenylephrine and blocked by phenoxybenzamine. Isoproterenol and dichloroisoproterenol were without effect. NE and E suppressed the spontaneous firing of BST neurons and discharges elicited by ST stimulation. Dopamine was a less potent depressant. [D-Ala2]-Met-enkephalinamide (EKA) suppressed the field potentials and spike discharges elicited by ST stimulation. Spikes occurring spontaneously or during administration of glutamate were also suppressed by EKA. The action of EKA was blocked by naloxone. Late inhibition induced by stimulation of the lateral division of the ST was blocked by naloxone in about a third of the neurons examined. These results indicate that norepinephrine suppresses the activity of BST neurons by activating postsynaptic α-receptors. It is also suggested that opioid peptides mediate inhibitory control of the amygdala over the BST.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238883
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  • 5
    Electronic Resource
    Electronic Resource
    Blocking action of pentobarbital on receptors for excitatory amino acids in the guinea pig hippocampus (1985)
    Springer
    Experimental brain research 59 (1985), S. 226-231 
    Details
    ISSN: 1432-1106
    Keywords: Excitatory amino acid ; Barbiturate ; Glutamate ; Receptor ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actions of pentobarbital sodium (Pent) on receptors for glutamate (Glu) and related compounds were studied in thin sections of the guinea pig hippocampus. Depolarizations induced by Glu and quisqualate (Quis) in CA3 neurons were reduced in amplitude during iontophoretic administration of Pent. This action of Pent was not accompanied by any noticeable changes in membrane potential or neuron input resistance. Depolarizations induced by N-methyl-D-aspartate were less sensitive to Pent. The fast kainate (KA) response was as susceptible as the Glu response, whereas the slow KA response was unaffected by Pent in three quarters of the neurons examined. Pent suppressed the Glu response at lower concentrations than required to potentiate responses to gamma-amino butyric acid. Excitatory postsynaptic potentials (EPSPs) elicited by stimulation of mossy fibers were suppressed by Pent. The EPSPs were a little more resistant to Pent than were the Glu responses. These results indicate that Pent blocks receptors for excitatory amino acids in the hippocampus. Of the three different populations of the receptors, Quis receptors are the most sensitive to Pent and KA receptors are the least sensitive. The suppression of the EPSPs is in accordance with the notion that Glu is the transmitter released from mossy fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230901
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds (1985)
    Springer
    Experimental brain research 60 (1985), S. 323-329 
    Details
    ISSN: 1432-1106
    Keywords: Excitatory amino acid ; Uptake inhibitor ; Glutamic acid ; Kainic acid ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Actions of dihydrokainate (DHKA) and 3-hydroxy-DL-aspartate (HAsp), inhibitors of high-affinity uptake for L-glutamate (Glu), were studied in vitro in thin hippocampal slices of the guinea pig. The amplitude of the depolarizations induced by Glu and by L-aspartate (Asp) in CA3 neurons are markedly augmented by DHKA and HAsp. Depolarizations induced by D-homocysteate (DH) were unaffected by the inhibitors. In about half of the neurons, depolarizations induced by L-homocysteate (LH) and by quisqualate (Quis) were slightly augmented by the inhibitors. Fast responses to kainate (KA) were augmented by the inhibitors to a similar extent as were Glu responses whereas slow KA responses were insensitive to HAsp. HAsp was without effect on excitatory postsynaptic potentials elicited by stimulation of granular layer. These findings are in general agreement with the biochemical data on amino acid uptake processes and are also consistent with the slow time-courses of depolarizations induced by DH, LH and Quis. Augmentation of fast KA responses provides strong evidence for the hypothesis that an KA pulse causes a liberation of Glu and/or Asp from the tissue and the liberated amino acid(s) induces the fast KA response in neurons nearby.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235927
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  • 7
    Electronic Resource
    Electronic Resource
    Monte Carlo calculations of escape fractions in the determination of fricke G-values for monochromatic soft X-rays
    Amsterdam : Elsevier
    International Journal of Radiation Applications & Instrumentation. Part C, 38 (1991), S. 11-15 
    Details
    ISSN: 1359-0197
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1359-0197(91)90038-4
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Spectroscopic characterization of plastocyanin from hornwort
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 136 (1986), S. 610-615 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(86)90484-5
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  • 9
    Electronic Resource
    Electronic Resource
    Generation of hybridomas producing human monoclonal antibodies against herpes simplex virus after in vitro stimulation
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 135 (1986), S. 495-500 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(86)90021-5
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  • 10
    Electronic Resource
    Electronic Resource
    Vitamin E status of pregnant women with respect to platelet and buccal mucosal cell tocopherol levels
    Amsterdam : Elsevier
    Pathophysiology 1 (1994), S. 69-72 
    Details
    ISSN: 0928-4680
    Keywords: (Buccal mucosal cell) ; (Human) ; (Platelet) ; Alpha-tocopherol ; Pregnancy
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0928-4680(05)80014-8
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    Paper (German National Licenses)
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