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  • 1
    Electronic Resource
    Electronic Resource
    Morphogenetic substances in nerve-depletedhydra (1979)
    Springer
    Development genes and evolution 187 (1979), S. 323-328 
    Details
    ISSN: 1432-041X
    Keywords: Nerve-depletedhydra ; Morphogenetic substances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary By a double colchicine treatment the nerve-cell population ofhydra was reduced to less than 1% of the normal complement. Such severely nerve-depletedhydra contained normal or higher than normal concentrations of head activator, head inhibitor, foot activator and foot inhibitor which in normal animals are produced by nerve cells. According to typical chromatographic properties all four morphogenetic substances were chemically identical to those found in normal animals. It is suggested that in nervedepletedhydra the epithelial cells, as the only remaining cell type, have taken over the morphogen-producing function of nerve cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848467
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Head regeneration inHydra is initiated release of head activator and inhibitor (1976)
    Springer
    Development genes and evolution 180 (1976), S. 287-295 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Head regeneration ; Morphogenetic substances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Hydra regenerating heads release at least two substances into the surrounding medium: one stimulates and one inhibits head formation. The inhibitor is released mainly during the first hour after cutting, the activator is released more slowly with a maximum in the second hour and with substantial release still during the following six hours. The release of both substances seems to be specific for head regeneration: it is not found in animals regenerating feet. The sequential release of these substances leads to the early changes observed at the cellular level during head regeneration inhydra: the inhibitor produces a decrease, the activator an increase in the mitotic activity of interstitial and epithelial cells, if assayed on intact animals. Head regeneration is blocked, if the release of the head activator is prevented. It is therefore suggested that these substances are necessary to initiate head regeneration inhydra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848775
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  • 3
    Electronic Resource
    Electronic Resource
    Separation and specificity of action of four morphogens from hydra (1979)
    Springer
    Development genes and evolution 186 (1979), S. 139-149 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Morphogenetic substances ; Regeneration ; Budding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A procedure is presented by which four previously described morphogenetic substances can be purified from hydra: an activator and an inhibitor of head formation and an activator and an inhibitor of foot formation. We show that all four substances act specifically. At low concentrations, the head factors only influence head and not foot formation, and the foot factors only influence foot and not head formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848175
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A new biochemical marker for foot-specific cell differentiation in hydra (1985)
    Springer
    Development genes and evolution 194 (1985), S. 453-461 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Peroxidase activity ; Foot cell differentiation ; Foot activator ; Foot inhibitor ; Head inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mucous cells in the basal disk of hydra contain a peroxidase-like enzyme allowing specific staining of these cells with substrates for peroxidases. The peroxidase activity provides an excellent marker for foot mucous cell, differentiation and was used to follow the reappearance of footspecific cells during foot regeneration after amputation. By choosing the appropriate either soluble or precipitable substrate the peroxidase reaction was used both for a qualitative and for a quantitative evaluation of foot-specific differentiation in hydra. For histological studies diaminobenzidien was found to be a suitable substrate which forms a dark brown precipitate within the cells containing the peroxidase activity. For a quantitative evaluation of foot regeneration the soluble substrate 2,2-azino-di(3-ethyl-benzthiazoline-sulfonic acid-6) ammonium salt was used which after reaction with the enzyme gives rise to a diffusible green reaction product the concentration of which can be measured by its specific absorption at 415 nm. Based on the diffusible enzyme product a new quantitative assay for foot regenration was developed and applied to confirm the effect and specificity of morphogenetic substances which either inhibit or activate foot or head regeneration in hydra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00868146
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of morphogenetic mutants of hydra (1981)
    Springer
    Development genes and evolution 190 (1981), S. 191-196 
    Details
    ISSN: 1432-041X
    Keywords: Morphogenetic mutants ; Hydra ; Head regeneration ; Morphogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The mutantreg-16 is deficient in head regeneration and abnormal in size regulation. The gastric region becomes twice as long as that of normal animals before the first bud is produced. Both mutant characteristics are due to changes in head-specific morphogen concentrations.Reg-16 contains twice as much head inhibitor and only half as much head activator in its head as normal animals. This leads to a higher level of free head inhibitor in the whole animal resulting on one hand in a greater distance of buds from the head, and on the other hand in a total blockage of release of head activator and head inhibitor which would be necessary to initiate head regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848302
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  • 6
    Electronic Resource
    Electronic Resource
    Properties of the foot inhibitor from hydra (1980)
    Springer
    Development genes and evolution 188 (1980), S. 133-139 
    Details
    ISSN: 1432-041X
    Keywords: Hydra ; Morphogenetic substances ; Regeneration ; Pattern formation ; Sea anemones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A substance was isolated from crude extracts of hydra that inhibits foot regeneration. This substance, the foot inhibitor, has a molecular weight of ≦500 daltons. It is a hydrophilic molecule, slightly basic in character and it has no peptide bonds. The pruified substance acts specifically and at concentrations lower than 10−7 M. At this low concentration only foot and not head regeneration is inhibited. Hydra are sensitive to purified foot inhibitor between the second and eight hour after initiation of foot regeneration by cutting. In normal animals the foot inhibitor is most likely produced by nerve cells. A substance with similar biological and physico-chemical properties is found in other coelenterates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848805
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The three sorCS genes are differentially expressed and regulated by synaptic activity (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2004.02286.x
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  • 8
    Electronic Resource
    Electronic Resource
    Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans (1981)
    [s.l.] : Nature Publishing Group
    Nature 293 (1981), S. 579-580 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Head activator, as assayed by its biological effect on hydra, was found in brain and intestine of cow, pig, rat and human5'6. The hypothalamus of an adult rat contained 105 hydra equivalents, the intestine 10 times more. Cow and pig contained comparable amounts per animal. The best source was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/293579a0
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