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  • 1
    Electronic Resource
    Electronic Resource
    Chromosomenanomalien in den Blutzellen eines Kindes mit multiplen Abartungen (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 1058-1067 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird ein Kind mit multiplen Abartungen des Skelets, verbunden mit statischer und geistiger Retardierung beschrieben, bei dem die Chromosomenanalyse aus Blutzellen mehrere Anomalien aufdeckte: Trisomie eines großen Chromosoms der Gruppe C mit Mosaikstruktur, welches möglicherweise ein isopyknotisches X-Chromosom darstellt (XXY/XY), Deletion eines Chromosoms 22, deutlich markierte Satelliten eines Chromosoms 21. Die Befunde werden mit den Ergebnissen der Literatur verglichen und ausführlich diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484591
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  • 2
    Electronic Resource
    Electronic Resource
    Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome — a report of two cases (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 384-387 
    Details
    ISSN: 1432-1076
    Keywords: Renal Fanconi syndrome ; Ifosfamide ; Nephrotoxicity ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients developed renal Fanconi syndrome (RFS) after intensive long-term chemotherapy for metastatic Ewing sarcoma and disseminated neuroblastoma. Whereas RFS was diagnosed in patient 1 before he developed osteomalacia, patient 2 experienced severe rickets and growth retardation. Renal function studies revealed slight glomerular impairment and severe tubular defects leading to increased excretion of glucose, amino acids, inorganic phosphate and low molecular weight proteins, indicating proximal tubular damage. Patient 2 additionally showed distal tubular dysfunction with acidosis and diminished concentrating capacity. Renal biopsy in patient 1 revealed marked proximal tubular defects without interstitial lymphocytic infiltration. In both patients renal damage could most likely be ascribed to previous ifosfamide (IFOS) therapy. Our patients showed no improvement in renal function after cessation of IFOS treatment, indicating a poor prognosis of once established RFS after IFOS therapy. Measurement of tubular reabsorption capacities provides exact information on the extent of tubular toxicity induced by IFOS and may be used to monitor IFOS treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113264
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  • 3
    Electronic Resource
    Electronic Resource
    The results of short-term (6 months) high-dose testosterone treatment on bone age and adult height in boys of excessively tall stature (1988)
    Springer
    European journal of pediatrics 148 (1988), S. 104-106 
    Details
    ISSN: 1432-1076
    Keywords: Tall stature ; Short-term high-dose testosterone treatment ; Bone age ; Adult height
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Forty-nine pubertal tall boys with a mean height prediction of 203.59 cm according to the Bayley-Pinneau (BP) method were treated prospectively with 500 mg testosterone-oenanthate every 2 weeks for a period of 6 months. Before therapy chronological age (CA) was 14.14 years and bone age (BA) 13.88 years using the Greulich-Pyle (GP) method. During therapy BA advanced by 1.37 years. It continued to accelerate during the 6 months following therapy with the mean ΔBA/ΔCA being 3.01 at 3 months and 2.24 at 6 months after therapy. The 6 months value was only slightly less than the ΔBA/ΔCA of 2.47 obtained during therapy. The reduction in adult height was 7.26 cm or 50.8% of the predicted further growth in 12 boys with a long-term follow up of 2.5 years. This is similar to the 51.6% or 9.63 cm observed in 50 boys with a long-term follow up after 14.25 month treatment until a BA of 17 years or more. It is concluded that in the majority of cases high-dose testosterone therapy in boys of tall stature can be limited to a 6-month treatment period. Reassessment of the height prediction after a 6-month interval without therapy should define those patients who have to resume treatment because of their remaining excessive growth potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445913
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  • 4
    Electronic Resource
    Electronic Resource
    Karyotypes in acute childhood leukemias may lose prognostic significance with more intensive and specific chemotherapy
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 54 (1991), S. 277-279 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(91)90224-I
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  • 5
    Electronic Resource
    Electronic Resource
    Frequency and Clinical Significance of DNA Aneuploidy in Acute Leukemia (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 468 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb42042.x
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  • 6
    Electronic Resource
    Electronic Resource
    21. Therapie maligner Weichteiltumoren bei Kindern (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 153-156 
    Details
    ISSN: 1435-2451
    Keywords: Soft tissue sarcomas in children ; Therapy ; Weichteilsarkome bei Kindern ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Kindern sind gut die Hälfte der malignen Weichteiltumoren Rhabdo myosarkome. Der konsequente Ausbau der Chemotherapie im Rahmen multidisziplinärer Behandlungsstrategien hat die Chance auf endgültiges tumorfreies Überleben auf über 50 erhöht. Eine primäre radikale Operation ist anzustreben, wenn der Tumor ohne schwere Verstümmelungen entfernt werden kann (vorwiegend an Extremitäten und Stamm). In allen anderen Fällen kommt der Chemotherapie die Priorität zu. Die Lokaltherapie (Radiotherapie, evtl. Operation) wird dann später eingeschoben (vor allem bei Sitz im Kopf- und Beckenbe reich).
    Notes: Summary More than half of the malignant soft tissue tumors in children are rhabdomyo sarcomas. Intensive chemotherapy as part of a multidisciplinary approach has increased the chances for tumor-free survival to more than 50 %. A primary radical surgical resection of the tumor is favored if this can be achieved without major disfigurement (mainly extremities and trunk). Chemotherapy has priority in all other cases which is followed by local radiotherapy and/or surgery (mainly if located in the area of the head or pelvis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286831
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  • 7
    Electronic Resource
    Electronic Resource
    Chemotherapy for bone marrow relapse of childhood acute lymphoblastic leukemia (1989)
    Springer
    Cancer chemotherapy and pharmacology 24 (1989), S. S16 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Results of the BMF study group trials ALL-REZ 83 and 85 for relapsed acute lymphoblastic leukemia (ALL) are presented. For children with late marrow relapse, remission rates of about 90% were seen in both studies. In children treated for early marrow relapse, the remission rate in study ALL-REZ 85 was superior (86% vs 62%). The probability of event-free survival for all patients and for those with early marrow relapse was also statistically significant (P〈0.05). Children with T-cell ALL had an extremely unfavourable prognosis in both studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253232
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  • 8
    Electronic Resource
    Electronic Resource
    Urinary excretion of the enantiomers of ifosfamide and its inactive metabolites in children (1991)
    Springer
    Cancer chemotherapy and pharmacology 28 (1991), S. 455-460 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The precondition for the antineoplastic effect of ifosfamide (ifo) is the oxidation of the oxazaphosphorine ring system, which contains a chiral centre at the phosphorous atom. This “ring oxidation” leads to the formation of alkylating mustard via several steps. A second metabolic pathway produces the cytostatically inactive metabolites 2- and 3-dechloroethyl-ifosfamide (2-d- and 3-d-ifo). The urinary excretion of the optical isomers of unmetabolised ifo and of 2- and 3-d-ifo, which represents the amount of ifo that has not been activated, was investigated by capillary gas chromatography for 18 treatment cycles in 14 children on various therapeutic schedules. The total cumulative excretion in 12 completely sampled cycles ranged from 27% to 50% of the ifo dose. Between 14% and 34% of the dose could be detected as ifo; 9% to 29%, as 3-d-ifo; and 2% to 8%, as 2-d-ifo. At 24 h after the end of therapy, excretion was nearly complete. Without exception, slightly more R-ifo (53%–61%) than S-ifo was excreted. S-2-d-ifo (50%–73%) was the main 2-d-metabolite. S-3-d-ifo (deriving from R-ifo) predominated in 6 of 14 children and R-3-d-ifo, in 8. Enantiomer-specific excretion increased after the end of infusion (up to 73% for R-ifo and 27% for S-ifo). We demonstrated stereospecific metabolism of ifo in children, with two different patterns of side-chain oxidation being observed. There was no evidence of important stereospecific ring oxidation in most children. A benefit should not be expected from the therapeutic application of pure enantiomers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685822
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  • 9
    Electronic Resource
    Electronic Resource
    Endodermal germ cell carcinoma (endodermal sinus tumor) of the vagina in infant girls (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 295-306 
    Details
    ISSN: 1432-1335
    Keywords: Endodermal sinus tumor ; Pathology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An endodermal sinus tumor (endodermal germ cell carcinoma) was diagnosed in a 1-year-old girl in the vagina after vaginal hemorrhage; the tumor was completely removed by radical abdominal surgery. Postoperative polychemotherapy was performed for two years with Actinomycin D, Adriamycin, Vincristin, and Cyclophosphamide. The infant is now tumor-free for 26 months, showing almost normal somatic and psychic development. The characteristic histological patterns and clinical course of this strongly malignant tumor are demonstrated, based on 25 published casereports of endodermal sinus tumors in the vagina of little girls (aged 5–26 months). This neoplasm in early infancy has to be separated from the clear-cell adenocarcinoma of the vagina which occurs after puberty in adolescent girls and young women, and is induced by stilbestrol therapy to the mother during early pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419289
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  • 10
    Electronic Resource
    Electronic Resource
    Childhood leukemia: cooperative Berlin-Frankfurt-Münster trials in the Federal Republic of Germany (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 100-103 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01612648
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