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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 1209-1215 
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Nephropathy ; Serum beta2-microglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Detection of early diabetic nephropathy is necessary to postpone or even prevent progression of irreversible kidney damage by therapeutic measures. Beta2-microglobulin (β2-MG) as a parameter of the glomerular filtration rate has been measured by immunoassay in the serum of 100 diabetic subjects, 50 insulin-dependent (IDD), and 50 noninsulin-dependent (NIDD) patients. The results are compared with endogenous creatinine-clearance, serum creatinine concentration, and proteinuria and are related to different stages of diabetic retinopathy (RD). Normal values were obtained from 50 healthy age- and sex-matched subjects. A close correlation was found between β2-MG levels and endogenous creatinine clearance. Thirty-nine diabetics revealed an elevated β2-MG (2.5 mg/l or higher), only 16 of whom had increased serum creatinine levels (1.4 mg/dl or higher). Significant differences of β2-MG were obtained between each group of patients with different stages of RD. A relevant difference of serum creatinine was found only between patients with normal eye fundus and advanced proliferative retinopathy, respectively. Without RD 26% of the patients revealed elevated β2-MG but normal creatinine values demonstrating a “latent nephropathy”, just 8% showed an increase of both parameters. Of the diabetics with proliferative retinopathy 40% suffered from impaired kidney function proven by reduced creatinine clearance and by elevation of β2-MG and creatinine as well, 15% just revealed an increase of β2-MG with normal creatinine levels. The incidence and extent of nephropathy demonstrated by pathologic values of both β2-MG and serum creatinine were significantly higher in IDD patients with a smaller proportion of “latent nephropathy” as compared to NIDD patients (p〈0.02). This is also true for the markedly increased proteinuria in IDD subjects. In both groups, measurement of β2-MG disclosed more often decrease of renal function in diabetics than did concentrations of serum creatinine. The determination of serum β2-MG appears to be a reliable and sensitive method for the early detection of minor impairment of kidney function in diabetes mellitus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics B (Proceedings Supplements) 8 (1989), S. 125-127 
    ISSN: 0920-5632
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Ultrasonics 31 (1993), S. 417-420 
    ISSN: 0041-624X
    Keywords: chirp signals ; optimum bandwidth ; pulse compression
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Engineering and Design 144 (1993), S. 177-198 
    ISSN: 0029-5493
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 334 (1989), S. 451-456 
    ISSN: 1434-601X
    Keywords: 12.40.Aa ; 13.75.Gx
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The(q¯ q) creation and annihilation terms of the one-gluon-exchange Lagrangian are incorporated into the quark cluster model. A resonating group study of theπ N interaction within this extended model yields scattering phase shifts which are in qualitative agreement with experiment without any parameter adjustment.
    Type of Medium: Electronic Resource
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