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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 2 (1983), S. 327-334 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bacteroides fragilis grown in the presence of sub-inhibitory concentrations of clindamycin was shown to be altered its degree of encapsulation and susceptibility to phagocytosis by human polymorphonuclear leukocytes. Little polysaccharide capsule could be demonstrated either by light or transmission electron microscopy when the bacteria were grown anaerobically for four hours in the presence of 1/2 MIC of clindamycin. Such clindamycin-grown cells could be opsonized by normal human serum, and although less complement was consumed in the process, were more effectively taken up by the leukocytes than bacteria grown in the absence of the drug (45 % versus 24 %). It was also shown that drug treatment caused significant cellular leakage in the presence of serum, the3H-label appearing extracellularly. In addition there was greater loss of viability of the bacterial cells grown in the presence of the drug and subsequently exposed to the leukocytes for 60 min.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Infection 6 (1978), S. S102 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Wirkung von 20 verschiedenen Antibiotika auf die Chemotaxis menschlicher Neutrophiler unter Verwendung einer kürzlich ausgearbeiteten Agarosegel-Technik untersucht. Mit Rifampin und Natriumfusidat inkubierte menschliche Leukozyten zeigten eine deutlich verminderte induzierte Wanderung, und zwar bei klinischen Konzentrationen. Bei hohen Konzentrationen ergab sich eine deutliche Herabsetzung bei neueren, gutresorbierbaren Tetracyclinen und eine weniger ausgeprägte Hemmung beim klassischen Tetracyclinchlorid. Bei hohen Konzentrationen von Chloramphenicol, Erythromycin und Nitrofurantoin fand sich ein leicht bis mäßiger Hemmeffekt. Der Einbau von14C-Leuzin zu einer trichloressigsäure-unlöslichen Form in menschliche Neutrophile wurde durch Rifampin, Natriumfusidat und neuere gutresorbierbare Tetracycline stark, durch das klassische Tetracyclin und Nitrofurantoin leicht gehemmt, Chemotaxis und Leuzineinbau wurden durch Gentamycin und Clindamycin zwar etwas gehemmt, aber nicht statistisch signifikant herabgesetzt. Eine Hemmung weder der Chemotaxis noch des Leuzineinbaues war für Penicilline, Cephalosporine, Nalidixinsäure, Sulfamethoxazol und Trimethoprim festzustellen.
    Notes: Summary The effect of 20 different antibiotics on chemotaxis in vitro by human neutrophils was studied. A recently developed agarose gel technique was used. Human leucocytes incubated with rifampin and sodium fusidate showed markedly depressed directional migration. This effect was obvious at clinically obtainable concentrations. However, the albumin binding for fusidic acid is high and this may reduce the in vivo effect on chemotaxis of this drug. Thus, whether this impairment of neutrophil function also takes place in vivo remains unknown. At high concentrations there was a definite depression for newer well absorbed tetracyclines and a less pronounced inhibition for classical tetracycline chloride. A slightly to moderately depressive effect was detected at high concentrations for chloramphenicol, erythromycin and nitrofurantoin. The incorporation of14C-leucine into a trichloro-acetic acid-insoluble form by human neutrophils was markedly depressed by rifampin, sodium fusidate and newer well absorbed tetracyclines and slightly depressed by classical tetracycline and nitrofurantoin. It is suggested that some antibiotics acting by protein synthesis inhibition also affect chemotaxis of human neutrophil leucocytes. There was a tendency to inhibition but no statistically significant depression of chemotaxis and leucine incorporation for gentamicin and clindamycin. No apparent inhibition of neither chemotaxis nor leucine incorporation could be detected for penicillins, cephalosporins, nalidixic acid, sulfametoxazol and trimethoprim.
    Type of Medium: Electronic Resource
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