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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 29 (2002), S. 0 
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The aim of this study was to determine the distribution patterns of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in periodontitis patients after standard mechanical periodontal therapy, and to evaluate the effect of additional local antibiotic therapy, given to all teeth with cultural evidence of these bacteria.Methods: 17 patients were included. 852 separate subgingival microbial samples were taken from the mesial and distal aspect of every tooth in 17 subjects at baseline. 46 of these samples, from 10 positive subjects, showed cultural evidence for P. gingivalis. 82 samples, from 5 subjects, were A. actinomycetemcomitans-positive. Three subjects showed no evidence for persistence of A. actinomycetemcomitans or P. gingivalis. In the other 14 subjects, all A. actinomycetemcomitans- or P. gingivalis-positive teeth were treated with tetracycline fibers (ACTISITE®). Sub-gingival microbial samples were again taken from two sites of every tooth, 1 month after fiber removal. 89% of the initially P. gingivalis-positive sites were now negative, but 16 previously negative sites now tested positive. 77% of the initially A. actinomycetemcomitans-positive sites were now negative, but 5 previously negative sites now tested positive. The teeth with persisting P. gingivalis or A. actinomycetemcomitans were again treated with fibers. Two sites of every tooth were once more sampled after 1 month. At this time, 5 subjects still showed cultural evidence of P. gingivalis at a total of 19 sites, and 4 subjects were positive for A. actinomycetemcomitans in a total of 27 sites. These 9 patients were finally submitted to systemic antibiotic therapy (3 × 250 mg metronidazole plus 3 × 375 mg amoxicillin/d for 7 days). Despite of all efforts, P. gingivalis was again detected 3 months later in isolated sites in 3 subjects, and A. actinomycetemcomitans could be cultivated from one single site.Conclusions: Therapy with tetracycline fibers guided by microbiological diagnosis effectively reduced P. gingivalis and A. actinomycetemcomitans locally, but was unable to completely eradicate the target organisms. Additional systemic antibiotic therapy further reduced P. gingivalis and A. actinomycetemcomitans. The observed persistence patterns suggest that reemergence of A. actinomycetemcomitans was due to recolonization, whereas the strikingly reproducible local reemergence of P. gingivalis in some sites indicated failed eradication.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Clinical oral implants research 16 (2005), S. 0 
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives: The aim of this prospective cohort study was to evaluate the success rate of titanium screw-type implants with the sandblasted and acid-etched (SLA) surface loaded early, after 6 weeks of healing.Material and methods: A total of 104 implants were inserted into posterior sites of 51 partially edentulous patients exhibiting bone densities of class I–III. After a healing period of 6 weeks, all implants were functionally loaded with cemented crowns or fixed partial dentures. The patients were recalled at 3, 12, 24, 36, 48 and 60 months for clinical and radiographic examination.Results: One implant failed to integrate during healing, and three implants were lost to follow-up and were considered drop-outs. The remaining 100 implants showed favorable clinical and radiographic findings at the 5-year examination. The peri-implant soft tissues were stable over time; the mean probing depths and mean attachment levels did not change during the follow-up period. None of the radiographs exhibited signs of continuous peri-implant radiolucency, which confirmed ankylotic stability for all 100 implants. The measurement of the bone crest levels (DIB values) indicated stability as well. Based on strict success criteria, all 100 implants were considered successfully integrated, resulting in a 5-year success rate of 99%.Conclusion: This prospective study using an early loading protocol with 6 weeks of healing demonstrated that titanium implants with the SLA surface can achieve and maintain successful tissue integration with high predictability for at least 5 years of follow-up in selected patients and sites.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 119 (1986), S. 472-481 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Funktionell substituierte Vinyllithiumverbindungen, 25. Heteroatom-Einfluß auf die vinylische DeprotonierungDie direkte Lithiierung von (E)-(Phenylvinyl)phosphonat 2 mit LDA erfolgt an der 1-Stellung und liefert mit Elektrophilen die Verbindungen 3. Das (Z)-1-(Ethylsulfinyl)-2-(ethylthio)-ethylen 7 gibt mit Methyllithium als Base ebenfalls bevorzugt 1-Lithiierung zu (Z)-7A. Nach den Reaktionen mit Elektrophilen ist die lithiierte Spezies jedoch nicht konfigurationsstabil. In Abhängigkeit von der Temperatur und der Zeit werden mit Elektrophilen (Z)- und (E)-Produkte erhalten. Die 1,3-Dithiole 10a - c werden substituentenabhängig entweder an 2-oder 5-Stellung lithiiert; bei höheren Temperaturen oder verlängerter Reaktionszeit fragmentieren die lithiierten Spezies. Das 1,3-Dioxol 14b liefert ein Produkt aus vinylischer Lithiierung.
    Notes: Direct lithiation of (E)-(phenylvinyl)phosphonate 2 with LDA takes place at 1-position; with electrophiles compounds 3 were obtained. The (Z)-1-(ethylsulfinyl)-2-(ethylthio)ethylene 7 delivers on reaction with methyllithium mainly the 1-lithiated species (Z)-7A. According to reactions with electrophiles, this functionally substituted vinyllithium species is configurationally labile. Depending on reaction temperature and time with electrophiles either (Z)-or (E)-products were obtained. Depending on substituents the 1,3-dithioles 10a - c were lithiated either in 2- or 5-position; higher reaction temperature or prolonged reaction time leads to fragmentation of the lithiated species. The 1,3-dioxole 14b gave only a product of vinylic lithiation.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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